Issue 30, 2012

Development of strong Brønsted base catalysis: catalytic direct-type Mannich reactions of non-activated estersvia a product-base mechanism

Abstract

A catalytic Mannich reaction of a simple ester with no activating functionality at the α-position via a product-base mechanism was reported. The desired Mannich adducts were obtained in high yields using a catalytic amount of KH. This is a rare example of a Brønsted base-catalyzed Mannich reaction of unactivated esters as substrates.

Graphical abstract: Development of strong Brønsted base catalysis: catalytic direct-type Mannich reactions of non-activated esters via a product-base mechanism

Supplementary files

Article information

Article type
Communication
Submitted
10 مارٕچ 2012
Accepted
02 اپریل 2012
First published
03 اپریل 2012

Org. Biomol. Chem., 2012,10, 5750-5752

Development of strong Brønsted base catalysis: catalytic direct-type Mannich reactions of non-activated esters via a product-base mechanism

Y. Yamashita, H. Suzuki and S. Kobayashi, Org. Biomol. Chem., 2012, 10, 5750 DOI: 10.1039/C2OB25522G

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