Issue 5, 2010

Exploring the cellular accumulation of metal complexes

Abstract

Transition metal complexes offer great potential as diagnostic and therapeutic agents, and a growing number of biological applications have been explored. To be effective, these complexes must reach their intended target inside the cell. Here we review the cellular accumulation of metal complexes, including their uptake, localization, and efflux. Metal complexes are taken up inside cells through various mechanisms, including passive diffusion and entry through organic and metal transporters. Emphasis is placed on the methods used to examine cellular accumulation, to identify the mechanism(s) of uptake, and to monitor possible efflux. Conjugation strategies that have been employed to improve the cellular uptake characteristics of metal complexes are also described.

Graphical abstract: Exploring the cellular accumulation of metal complexes

Article information

Article type
Perspective
Submitted
23 اکتوٗبر 2009
Accepted
11 نومبر 2009
First published
23 دسمبر 2009

Dalton Trans., 2010,39, 1159-1170

Exploring the cellular accumulation of metal complexes

C. A. Puckett, R. J. Ernst and J. K. Barton, Dalton Trans., 2010, 39, 1159 DOI: 10.1039/B922209J

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements