Issue 9, 2019

Rapid route design of AZD7594

Abstract

A wide variety of technology platforms were used to rapidly select a commercial manufacturing route to the inhaled glucocorticoid receptor modulator AZD7594. This collaborative approach to the route design employed idea generation, high-throughput salt formation, solubility and chemical reaction screening, process analytical techniques and factorial experimental design to propose, assess and select the new strategic route within a five-month window. The selected route is currently undergoing further process development and optimisation and will be implemented in future manufacturing campaigns to supply drug substance for ongoing clinical studies and ultimately for the commercially marketed product.

Graphical abstract: Rapid route design of AZD7594

Supplementary files

Article information

Article type
Paper
Submitted
15 مارٕچ 2019
Accepted
03 جوٗن 2019
First published
05 جوٗن 2019

React. Chem. Eng., 2019,4, 1658-1673

Rapid route design of AZD7594

H. L. Carter, A. W. Connor, R. Hart, J. McCabe, A. C. McIntyre, A. E. McMillan, N. R. Monks, A. K. Mullen, T. O. Ronson, A. Steven, S. Tomasi and S. D. Yates, React. Chem. Eng., 2019, 4, 1658 DOI: 10.1039/C9RE00118B

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements