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Synthesis of nicotinamide and fumaric acid supramolecular cocrystals with 1 : 1 and 2 : 1 amide to acid stoichiometries results in the formation of an amide–acid heterosynthon (1 : 1 stoichiometry) and an amide–amide homosynthon (2 : 1 stoichiometry) and different conformations of the fumaric acid moieties.