The recent advances of the visible-light-mediated photocatalytic cleavage of C–C and C–N bonds associated with amines and their derivatives, which featuring mild conditions, unique selectivity, broad substrate scope and green manner, are reviewed.
Photocatalytic ring opening of aminocyclopropanes enables the selective installation of N-acyl-N,O-acetal linkers on pyridines, thereby facilitating diverse downstream functionalizations and efficient late-stage molecular editing.
Cyclopropylamine synthesis: using halomethyl radicals as the CH2 source, photoredox-catalysed cyclopropanation of N-vinylimides could proceed well, giving modular access to 1- or 2-arylcyclopropylamines.
A photocatalyst- and additive-free multi-component reaction driven by cyclopropylamine-based EDA complex has been developed to access cyclopentylamines under water medium conditions.
Donor–acceptor aminocyclopropanes bearing both amino and carboxyl groups underwent catalytic asymmetric ring-opening reactions with diverse oxygen nucleophiles to afford chiral γ-oxygen-substituted γ-aminobutyric acid derivatives with good results.