Pyrazolopyridines have gained increasing attention in kinase-targeting anti-cancer drug discovery. This review analyzes the success stories wherein this bicycle was employed to address various challenges.
The aldehyde-functionalized pyrazolo[3,4-b]pyridine derivative CJ129 was examined in the solid state for the first time using single-crystal X-ray diffraction.
A general and convenient approach for the synthesis of biologically important pyrazolo[4,3-c]pyridines has been developed via amination of 5-acyl-4-pyridones with hydrazines.
The synthesis of fused N-heterocycles under microwave irradiation using HKUST-1 and evaluation of their in vitro biological activities.
The present review article focuses on recent advances in the nanocatalyzed multicomponent synthesis of hybrid molecules with structural diversity incorporating medicinally privileged heterocyclic substructures.