Recent progress in chemoenzymatic synthesis of human glycans

Shengzhou Ma, Jinhua Gao, Yinping Tian and Liuqing Wen

Org. Biomol. Chem., 2024, 22, 7767
DOI: 10.1039/D4OB01006J

Highly stereoselective α-glycosylation with GalN3donors enabled collective synthesis of mucin-related tumor associated carbohydrate antigens

Kunxiu Shou, Yunqin Zhang, Yujie Ji, Bin Liu, Qingli Zhou, Qiang Tan, Fuying Li, Xiufang Wang, Gang Lu and Guozhi Xiao

Chem. Sci., 2024, 15, 6552
DOI: 10.1039/D4SC01348D

Recent advances in chemoenzymatic synthesis of oligosaccharides and polysaccharides

Tomonari Tanaka

Polym. Chem., 2026, 17, 125
DOI: 10.1039/D5PY00938C

Glycosyltransferases as versatile tools to study the biology of glycans

Joshua M Kofsky, Jonathan L Babulic, Marie E Boddington, Fabiola V De León González and Chantelle J Capicciotti

Glycobiology, 2023, 33, 888
DOI: 10.1093/glycob/cwad092

Diversity-Oriented Module Synthesis of Multibranched O-GalNAc Glycans

Yuqing Xing, Yinshuang Li, Sai Yang, Shuang Li, Peixue Ling, Jingyao Qu and Junqiang Fang

ACS Catal., 2025, 15, 18834
DOI: 10.1021/acscatal.5c05290

A Regioselective and Modular Chemoenzymatic Strategy for the Synthesis of O‐GalNAc Glycans and Disialyl Galacto‐N‐Bioses

Min‐Cheng Chien, Ting‐Yi Lee, Avijit K. Adak and Chun‐Cheng Lin

Israel Journal of Chemistry, 2026, 66
DOI: 10.1002/ijch.70009

Recent advances in enzymatic and chemoenzymatic synthesis of N- and O-glycans

Zhi-Fei Hu, Kan Zhong and Hongzhi Cao

Current Opinion in Chemical Biology, 2024, 78, 102417
DOI: 10.1016/j.cbpa.2023.102417

Advances in the understanding and exploitation of carbohydrate-active enzymes

Rajneesh K. Bains, Seyed Amirhossein Nasseri, Jacob F. Wardman and Stephen G. Withers

Current Opinion in Chemical Biology, 2024, 80, 102457
DOI: 10.1016/j.cbpa.2024.102457

Silver Oxide Promoted Synthesis of Alpha O-GalNAc Containing Glyco-Amino Acids: Synthesis of Core 2 Containing Glyco-Amino Acids for Solid Phase Synthesis of Glycopeptides

Ousman Boye, Lisa Nicholson, Anna Marstall, Brooke Van Engen, Marika Van Slageren, Noah Mulder, Mostafa Ali Eldeen, Abe Hall, Anjaneyulu Putta, Sandeep K. Misra, Joshua S. Sharp and Hailiang Joshua Zhu

J. Org. Chem., 2025, 90, 30
DOI: 10.1021/acs.joc.4c01572

Sialoglycan engineering empowered by recombinant sialyltransferases

Sascha N. Woolcott, Isabelle Da Barp, Chantelle J. Capicciotti, Haissi Cui and Landon J. Edgar

Biochimica et Biophysica Acta (BBA) - General Subjects, 2026, 1870, 130927
DOI: 10.1016/j.bbagen.2026.130927

Characterization of Human Sialyltransferase ST6GalNAc5 and Its Use in the Synthesis of Internally α2,6-Sialylated Glycans

Hsin-Kai Tseng, Chun-Yen Wu, Hsien-Wei Tseng, Ke-Hong Lyu, Wen-Hua Kuo, Takashi Angata and Chun-Cheng Lin

ACS Catal., 2025, 15, 17815
DOI: 10.1021/acscatal.5c05889

Divergent Enzymatic Synthesis of a Comprehensive Type-1 Glycan Determinant Library

Guitao Bai, Tangliang Shen, MohammadHossein Shabahang, Shumin Bao, Shuquan Fan, Hongshuai Lv and Lei Li

ACS Catal., 2025, 15, 20605
DOI: 10.1021/acscatal.5c06702

Enzymatic Synthesis of Disialyllacto‐N‐Tetraose (DSLNT) and Related Human Milk Oligosaccharides Reveals Broad Siglec Recognition of the Atypical Neu5Acα2‐6GlcNAc Motif

Shumin Bao, Tangliang Shen, Mohammad Hossein Shabahang, Guitao Bai and Lei Li

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202411863

Divergent synthesis of amino acid-linked O-GalNAc glycan core structures

Madhusudhan Reddy Gadi, Jinghua Han, Tangliang Shen, Shuquan Fan, Zhongying Xiao and Lei Li

Nat Protoc, 2025, 20, 480
DOI: 10.1038/s41596-024-01051-6

Enzymatic Synthesis of Disialyllacto‐N‐Tetraose (DSLNT) and Related Human Milk Oligosaccharides Reveals Broad Siglec Recognition of the Atypical Neu5Acα2‐6GlcNAc Motif

Shumin Bao, Tangliang Shen, Mohammad Hossein Shabahang, Guitao Bai and Lei Li

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202411863

The sweet gatekeeper: Mucin-type O-glycans in brain endothelial glycocalyx and aging

Duan Lu Hou, Yun-Cheng Wu, Eng King Tan and Zhi Dong Zhou

Ageing Research Reviews, 2026, 117, 103068
DOI: 10.1016/j.arr.2026.103068