Role of NLRP3 inflammasome in nanoparticle adjuvant-mediated immune response

Abstract

The nucleotide-binding oligomerization domain (NOD)-like receptor (NLR) family pyrin domain-containing 3 (NLRP3) inflammasome is pivotal in orchestrating the immune response induced by nanoparticle adjuvants. Understanding the intricate mechanisms underlying the activation of NLRP3 inflammasome by these adjuvants is crucial for deciphering their immunomodulatory properties. This review explores the involvement of the NLRP3 inflammasome in mediating immune responses triggered by nanoparticle adjuvants. It delves into the signaling pathways and cellular mechanisms involved in NLRP3 activation, highlighting its significance in modulating the efficacy and safety of nanoparticle-based adjuvants. A comprehensive grasp of the interplay between NLRP3 inflammasome and nanoparticle adjuvants holds promise for optimizing vaccine design and advancing immunotherapeutic strategies.

Graphical abstract: Role of NLRP3 inflammasome in nanoparticle adjuvant-mediated immune response

Article information

Article type
Review Article
Submitted
26 Mar 2024
Accepted
04 Jun 2024
First published
05 Jun 2024
This article is Open Access
Creative Commons BY-NC license

Biomater. Sci., 2024, Advance Article

Role of NLRP3 inflammasome in nanoparticle adjuvant-mediated immune response

M. Ahmed, P. Kurungottu, K. Swetha, S. Atla, N. Ashok, E. Nagamalleswari, S. R. Bonam, B. D. Sahu and R. Kurapati, Biomater. Sci., 2024, Advance Article , DOI: 10.1039/D4BM00439F

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