Multi-modal Biosensing System Based on Metal Nanoparticles

Abstract

Biosensors are currently one of the most commonly used devices to analyze biomarkers, which play an important role in environmental detection, food safety, and disease diagnosis. Researchers have developed multi-modal biosensors instead of single-modal or dual-modal to meet the increasing requirements for sensitivity, accuracy, and stability of biosensors. Metal nanoparticles (MNPs) are beneficial to prepare a core probe of a multimodal biosensor because of their excellent physical and chemical properties, such as easy regulation and modification, can integrate diverse sensing strategies. This review mainly summarizes the excellent physicochemical properties of MNPs applied as biosensing probes, and the principles of commonly used MNPs-based multi-modal sensing strategies. The recent applications and possible improvements of multi-modal biosensors based on MNPs are also concluded, among which on-site inspection and sensitive detection are particularly considered. Current challenges and prospective of multimodal biosensors based on MNPs may provide readers with a new perspective on this field.