Issue 10, 2018

Menaquinone biosynthesis inhibition: a review of advancements toward a new antibiotic mechanism

Abstract

Menaquinone is essential in electron transport and ATP generation in all Gram-positive, and anaerobically respiring Gram-negative bacteria. By inhibiting menaquinone production in target organisms, bactericidal action can be achieved irrespective of the organisms' growth phase. This pathway is absent in human cells, as menaquinone is obtained only through the diet. This paper provides a succinct review of major advancements, where present, at all enzymatic steps of the biosynthetic pathway of menaquinone. Structure–activity relationships are evaluated, as well as results translating these relationships to growth inhibition studies.

Graphical abstract: Menaquinone biosynthesis inhibition: a review of advancements toward a new antibiotic mechanism

Associated articles

Article information

Article type
Review Article
Submitted
01 Dec 2017
Accepted
22 Jan 2018
First published
29 Jan 2018
This article is Open Access
Creative Commons BY license

RSC Adv., 2018,8, 5099-5105

Menaquinone biosynthesis inhibition: a review of advancements toward a new antibiotic mechanism

M. Boersch, S. Rudrawar, G. Grant and M. Zunk, RSC Adv., 2018, 8, 5099 DOI: 10.1039/C7RA12950E

This article is licensed under a Creative Commons Attribution 3.0 Unported Licence. You can use material from this article in other publications without requesting further permissions from the RSC, provided that the correct acknowledgement is given.

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