Accepted Manuscript -
Review Article
Advancing nucleic acid delivery through cationic polymer design: non-cationic building blocks from the toolbox
Rational design of polymer-based mRNA delivery systems for cancer treatment
This review introduces the basic design principles and recent advances in polymeric mRNA therapeutics, highlighting strategies to realize cancer-selective, organ-targeted, and tissue-penetrating mRNA delivery.
Recent developments of polymeric delivery systems in gene therapeutics
A brief overview of main strategies to improve the gene transfection efficiency of PCVs recently and their applications in certain diseases.
Predictive design of multimonomeric polyelectrolytes enables lung-specific gene delivery
With a discovery engine combining polymer chemistry, biology, and AI, lung-specific pDNA delivery is demonstrated with a single multimonomeric polyelectrolyte.
Paper
Stretched or wrinkled? Looking into the polymer conformation within polymersome membranes
This meta-study discusses if the hydropbobic parts of amphiphilic block-copolymers are in a stretched or wrinkled state within polymersomes. It depends on the nature of the polymer and the amount of repeating units in the hydrophobic block.
Paper
Polysarcosine functionalised cationic polyesters efficiently deliver self-amplifying mRNA
In this work we demonstrate the endcapping of a poly(beta-amino ester) of polysarcosine, a widely established PEG-alternative, and show its ability as a non-viral vector for self-amplifying mRNA.
Paper
PDEGMA-b-PDMAEMA-b-PLMA triblock terpolymers and their cationic analogues: synthesis, stimuli responsive self-assembly and micelleplex formation
Temperature and pH-responsive triblock terpolymers of the type PDEGMA-b-PDMAEMA-b-PLMA and their quaternized analogs are synthesized and utilized for micelleplex formation with linear DNA.
About this collection
Polymers are increasingly being studied as gene delivery vectors, with research ranging from fundamental studies to therapeutic applications. This themed collection will showcase the latest research in the field, with a focus on how the polymer’s design impacts functional properties and end use. Submitted papers will have a focus on how innovative polymer chemistry supports exciting properties, biological activity and/or therapeutic applications. Our aim for this collection is to celebrate the progress and strong contribution of polymer science in this area, and to inspire new research.
This themed collection is Guest Edited by Professor Sébastien Perrier (University of Warwick, ORCID: 0000-0001-5055-9046), Professor Youqing Shen (Zhejiang University, ORCID: 0000-0003-1837-7976), Professor Todd Emrick (University of Massachusetts Amherst, ORCID: 0000-0003-0460-1797), Professor Zhuxian Zhou (Zhejiang University, ORCID: 0000-0002-7104-9915) and Professor Marxa Figueiredo (Purdue University).