An efficient and facile rhodium(II) catalyzed denitrogenative method for the synthesis of 2-aminoquinoline derivatives from 2-quinolones and N-sulfonyl-1,2,3-triazoles has been described.
2-Quinolone is a privileged nitrogen heterocycle that is found in various bioactive and functional substances.
Geranyl esters, major components of many commercial fragrances, are extremely efficient by volume at restructuring aggregates of black carbon.
Computational docking reveals the influence of conformation on the inhibition of cytochrome P450 3A4. Such structure–activity relationships are dependent on intra-molecular interactions in cannabinoids, forming stabilised coiled structures.
A practical approach for preparing 3,4-fused 2-quinolones has been disclosed. The Rh(III)-catalyzed highly selective alkenyl C–H activation/annulation of 4-amino-2-quinolones was achieved via an unprecedented reversible alkyne insertion.