We demonstrate the oxathiaphospholane-based synthesis of novel P-stereodefined phosphorothioate N-modified morpholino analogs with confirmed stereochemistry and enzymatic stability, highlighting their potential for therapeutic applications.
We present P-stereodefined morpholino phosphorothioate analogs and provide valuable structural insights into their stereochemistry. These P-diastereomerically pure analogs could have a significant impact in the field of nucleic acid therapeutics.
This review highlights recent advances in stereoselective synthesis of P-stereogenic nucleotide prodrugs and oligonucleotides, covering both chemical and enzymatic strategies.
OTP method for the synthesis of P-stereodefined phosphorothioate has been extended to use activators TBD and Verkade base, which can be used interchangeably with DBU.
This article describes how the synergy between chemistry and biology facilitated the development of cyclic dinucleotides as a potential new treatment for cancer.