A powerful telescoped continuous flow platform enables the 20-minute synthesis of diverse benzimidazoles with broad scope (32 examples) and gram-scale pharmaceutical applicability.
Selective monoacylation and unsymmetric diamide formation reactions using acyl chlorides and diamines under ambient CO2 pressure (400 ppm – 1 atm), enabling facile synthesis of bioactive molecules.
This work provides a comprehensive overview of recent advances in the selective transformation of diols, focusing on diverse organocatalytic strategies and the mechanistic principles underlying selectivity control.
A catalytic stereoselective strategy to access P-stereogenic phosphinates through chiral 4-arylpyridine-N-oxide-catalyzed acylative desymmetrization of bisphenols has been reported.
A Ru-catalyzed C3–H acylation of 2-substituted heterocyclopentadienes with acyl chlorides, compatible with various N-directing groups. The reaction proceeds via rate-limiting C–H activation step, facilitated by in situ-generated carboxylate.