Inspired by the chemical reactivity of apalutamide, an efficient method for N-terminal cysteine bioconjugation with 2-cyanopyridine derivatives has been developed.
This review focuses clinical significance of CysC detection followed by detailed analysis of different CysC biosensing methods with emphasis on the necessity of PoC monitoring of CysC.
Herein we demonstrate organocatalyst-mediated protein aldol ligation (OPAL) modification of the bacteriocidin colicin Ia to afford mannose-presenting neoglycoproteins with potential utility for non-genetic glyco-engineering of E. coli cell surfaces.
The fundamentals of bio-orthogonal click chemistry are investigated, while exploring mechanistic intricacies, demonstrating the adaptability and promise of this methodology.