This review carefully summarizes the advances achieved in catalytic hydrofunctionalization of ynamides and is categorized by the bond formation type including C−C, C−X, C−O, C−N, C−S, C−P, C−Si, and C−Ge bonds.
Synthetic potential of ynamides and ynamide-derived advanced intermediates in cycloaddition reactions with different reaction partners to yield versatile heterocyclic adducts.
Metal-free [2 + 2] and [4 + 2] self-cycloadditions of N-aryl-substituted ynamides provide various valuable functionalized aminocyclobutenes and 4-aminoquinoline derivatives.
A novel metal-free Brønsted acid-catalyzed Ficini [2 + 2] cycloaddition of ynamides with enones under mild reaction conditions was described.
By investigation of the relative rates of Pd-catalyzed ene-ynamide cycloisomerization to form fused and spirocyclic rings, a sequence-controlled cascade has been developed to prepare the tetracyclic core of gelsemine in a single step.