A catalytic system-controlled divergent reaction was reported to construct three distinct nitrogen-containing heterocycles from readily available starting materials via a precise chemical bond activation and annulation cascade.
The advancements in the synthesis of nitrogen-containing heterocycles via Rh(III)-catalyzed chelation-assisted tandem C–H activation/carbene insertion/annulation with diazo compounds as carbene precursors have been summarized.
A novel series of pyrazolidinones and pyrazolidinediones was developed as selective COX-2 inhibitors, exhibiting anti-amyloid β, anti-tau, and neuroprotective activities.
We present an effective, visible light-driven method for the synthesis of N-(β-amino)pyrazolidin-3-ones from N-aryl glycine and azomethine imines.
Nitrogen bridgehead (NBH) is present in many natural products, but studies of synthetic analogues remain unexplored. This review gives an overview of NBH for potential applications.