Lipid-assisted PEG-b-PLA nanoparticles achieve stable and ultrahigh SN38 entrapment through attenuating intermolecular π–π stacking of SN38 for efficient cancer therapy.
By attaching hydrophilic OEG on different conjugation sites of SN38, isomeric self-assembling prodrugs were developed and self-assembled into giant nanotubes and filamentous assemblies, revealing the critical contribution of conjugation sites.
7-Ethyl-10-hydroxyl camptothecin (SN38), a semisynthetic derivative of camptothecin, exhibited extreme pharmacological activities in treating a range of cancers.
The rational combination of chemotherapy drugs can improve the curative effect of cancer treatment.
A schematic illustration of the different linker lengths of disulfide bond-bridged SN38 homodimeric prodrug nanoassemblies for cancer therapy.