Direct alteration of unactivated C–H bonds of organic building blocks.
The metal-free C–H functionalisation is providing environmentally benign, cost-effective, sustainable catalytic systems. Comprehensive developments of various metal-free C–H functionalisation reactions are the focal point of this review.
A copper(I)-catalyzed intermolecular alkylboration of terminal allenes using unactivated alkyl iodides as the carbon electrophiles is reported.
Recent progress in the assembly of chiral α-tertiary amines in the last decade via transition-metal catalysis is summarized.
We developed a copper-catalyzed stereoselective strategy for the unified synthesis of borylated methylenecyclobutanes. The versatile boromethylene unit greatly expands their structural diversity and potential in future drug discovery.