Laura De Luca, Lisa Lombardo, Salvatore Mirabile, Agostino Marrazzo, Maria Dichiara, Giuseppe Cosentino, Emanuele Amata and Rosaria Gitto
RSC Med. Chem., 2023,14, 1734-1742
Abstract
Discovery of potent S1R agonist by means of screening campaign and analysis of binding interactions.
Tobias Winge, Dirk Schepmann, Judith Schmidt, Constantin Daniliuc, Ernst-Ulrich Würthwein and Bernhard Wünsch
Org. Biomol. Chem., 2023,21, 7730-7752
Abstract
According to DFT calculations, the synthesis of spirocyclic σ1 ligands involves two aza-Michael additions or a [4 + 2] cycloaddition. Dispiro ligand with a high number of sp3 C-atoms shows promising σ1 affinity, selectivity and physicochemical properties.
Giuliana Costanzo, Giuseppe Cosentino, Margherita Grasso, Vincenzo Patamia, Sara Zuccalà, Alessandro Coco, Elisabetta Novello, Mahmoud Al-Khrasani, Raffaele Morrone, Giovanni Mario Pitari, Emanuele Amata, Agostino Marrazzo, Antonio Rescifina, Lorella Pasquinucci and Carmela Parenti
RSC Med. Chem., 2025,16, 1172-1187
Abstract
Compound 7 exhibited high σ1R affinity and selectivity and produced a potent antinociceptive effect in a mouse model of inflammatory pain. Molecular modeling studies were performed to analyze its key interactions with σ1R.
Nina Schulte-Gauczinski, Judith Schmidt, Jens Köhler, Dirk Schepmann and Bernhard Wünsch
Org. Biomol. Chem., 2026,24, 2118-2130
Abstract
The relative configuration and the substitution pattern control the interaction of 2-(2-phenyl1,3-dioxan-4-yl)ethan-1-amines with σ1 receptors or the PCP binding site of NMDA receptors.
Maria Cristina Lomuscio, Nicola Corriero, Vittoria Nanna, Antonio Piccinno, Michele Saviano, Rosa Lanzilotti, Carmen Abate, Domenico Alberga and Giuseppe Felice Mangiatordi
RSC Med. Chem., 2025,16, 835-848
Abstract
Developing sigma-1 receptor (S1R) modulators is considered a valuable therapeutic strategy to counteract neurodegeneration, cancer progression, and viral infections, including COVID-19.