Developments in the synthesis of indolizines during the last decade are reviewed, with special emphasis given to strategies relying on pyrrole derivatives and on π-expanded systems.
This work describes a dual catalytic system for selective synthesis of α-allyl-1,3-ketoaldehydes and α-vinyl-1,4-ketoaldehydes through cascade reactions of hydroxyl substituted aromatic enaminones with cyclopropenes under zinc promoted conditions.
Primary aldehydes are capable of cross-coupling with modified N-alkenoxyheteroarenium salts to construct C(sp3)–C(sp3) bonds with good chemical selectivity, offering structurally diverse 1,4-ketoaldehydes under metal-catalyst-free and ambient-temperature conditions.
The synthesis of small molecules and complex scaffolds is one of the most important topics in organic synthesis.
A novel divergent synthetic method for polysubstituted pyrroles from isocyanides and α,β-unsaturated ketones in the presence of a rhodium catalyst and bis(pinacolato)diboron (B2pin2) is described here.