Sándor Balázs Király, Balázs Buglyó, Otieno Michael Ooko, Attila Bényei, Erika Lisztes, Balázs István Tóth, Tamás Bíró, Kristóf Borozsnyai, Dávid Oláh, Gábor Vasvári, Dániel Nemes, Miklós Vecsernyés, Ferenc Fenyvesi and Tibor Kurtán
RSC Adv., 2026,16, 23585-23612
Abstract
Pentacyclic frameworks containing a pyrano[4,3-b]pyran unit condensed with a pyrone/pyridone and a tetrahydroquinoline/chroman subunit were assembled in a domino Knoevenagel-hetero Diels–Alder reaction.
Branislava Tenjović, Sofija Bekić, Andjelka Ćelić, Edward Petri, Julia Scholda, Florian Kopp, Marija Sakač and Andrea Nikolić
RSC Med. Chem., 2025,16, 232-246
Abstract
In this study, a series of 13 new D-ring fused steroidal N(2)-substituted-1,2,3-triazoles were synthesized, characterized and evaluated for their biological activities.
Serafim A. Tishchenko, Anastasiya S. Sokolova, Valeriya V. Samsonova, Julia G. Pushkareva, Nikolay I. Bormotov, Ivan A. Moskalev, Daria. E. Solomina, Artem D. Rogachev, Alina V. Fatyanova, Sophia S. Borisevich, Olga I. Yarovaya, Olga A. Serova, Alena S. Ovchinnikova, Alexander A. Sergeev, Larisa N. Shishkina, Artemiy A. Sergeev, Alexander P. Agafonov and Nariman F. Salakhutdinov
RSC Med. Chem., 2026,17, 2605-2629
Abstract
This study reports the design, synthesis, and comprehensive biological evaluation of a new class of orthopoxvirus inhibitors utilizing natural bicyclic monoterpenoid scaffolds as strategic replacements for synthetic polycyclic cores.
Sapna Singh, Archana Velloth, Manu Goyal, Navneet Kaur, Sanjay Singh and Sugumar Venkataramani
Chem. Commun., 2024,60, 10776-10779
From themed collection:
2024 CRSI Medal Winners Collection
Abstract
Design, synthesis, photoswitching and computational studies of N-methyl arylazo-3,5-(di-2-pyridyl)pyrazoles and their N-alkyl pyridinium derivatives as probes for pH modulation.
Yang-Yang Fu, Kun Hu, Song-Yu Hou, Bing-Chao Yan, Xiao-Nian Li, Xing-Zhi Yang, Han-Dong Sun and Pema-Tenzin Puno
Org. Chem. Front., 2025,12, 4247-4254
Abstract
Structures and enol–enol tautomerism of glutinosasins A–D, four novel 8,14-seco-ent-kaurane diterpenoids from Isodon glutinosus, were elucidated via quantum chemical calculations. Notably, glutinosasin D selectively inhibited SW480 tumor cells.