This review analyzes advances in plant alkaloid biosynthesis (2018–2025), highlighting key challenges in stereochemical control, cyclization, and tailoring modifications, and discusses synthetic biology strategies for microbial production.
This paper reviews the structure, biosynthesis, synthesis, and activity of corynanthe alkaloids with the aim of providing new perspectives and discoveries for researchers in this field.
This review presents the structural diversity of 73 stemmadenine and related alkaloids, as well as their biological activities, and fully describes the biosynthetic proposal for stemmadenine and the successful synthetic approaches.
Collective synthesis of geissolosimine, geissoschizoline, akuammicine, (16S)-deshydroxymethylstemmadenine and Aspidospermatan alkaloids was achieved based on a catalytic asymmetric double Michael addition.
A simple method to calculate a similarity metric between two synthetic routes, based on bonds formed and grouping of atoms in the target compound.