From genetic code to global health: the impact of nucleic acid vaccines on disease prevention and treatment

Alessandra Del Bene, Antonia D'Aniello, Salvatore Mottola, Vincenzo Mazzarella, Roberto Cutolo, Erica Campagna, Rosaria Benedetti, Lucia Altucci, Sandro Cosconati, Salvatore Di Maro and Anna Messere

RSC Med. Chem., 2025, 16, 2403
DOI: 10.1039/D5MD00032G

Access to capped RNAs by chemical ligation

Karolina Bartosik and Ronald Micura

RSC Chem. Biol., 2024, 5, 1104
DOI: 10.1039/D4CB00165F

GPT-driven generation and biological activity evaluation of novel mRNA trinucleotide Cap1 analogs for mRNA vaccine or immunotherapy

Honglei Zhang, Jingxuan Ma, Teng Ma, Yuqing Ma, Lijie Jin, Lijie Liu, Yangjian Liu, Kai Dong, Man Zhang, Dawei Huang, Fei Yu and Gengshen Song

J. Mater. Chem. B, 2025, 13, 7280
DOI: 10.1039/D5TB00750J

Trinucleotide mRNA Cap Analogue N6-Benzylated at the Site of Posttranscriptional m6Am Mark Facilitates mRNA Purification and Confers Superior Translational Properties In Vitro and In Vivo

Marcin Warminski, Edyta Trepkowska, Miroslaw Smietanski, Pawel J. Sikorski, Marek R. Baranowski, Marcelina Bednarczyk, Hanna Kedzierska, Bartosz Majewski, Adam Mamot, Diana Papiernik, Agnieszka Popielec, Remigiusz A. Serwa, Brittany A. Shimanski, Piotr Sklepkiewicz, Marta Sklucka, Olga Sokolowska, Tomasz Spiewla, Diana Toczydlowska-Socha, Zofia Warminska, Karol Wolosewicz, Joanna Zuberek, Jeffrey S. Mugridge, Dominika Nowis, Jakub Golab, Jacek Jemielity and Joanna Kowalska

J. Am. Chem. Soc., 2024, 146, 8149
DOI: 10.1021/jacs.3c12629

Application of Mammalian Nudix Enzymes to Capped RNA Analysis

Maciej Lukaszewicz

Pharmaceuticals, 2024, 17, 1195
DOI: 10.3390/ph17091195

Reactivity Profiling for High-Yielding Ynamine-Tagged Oligonucleotide Click Chemistry Bioconjugations

Frederik Peschke, Andrea Taladriz-Sender, Allan J.B. Watson and Glenn A. Burley

Bioconjugate Chem., 2024, 35, 1788
DOI: 10.1021/acs.bioconjchem.4c00353

Concise Affinity‐Based Purification of Ligated mRNA for Structure‐Activity Relationship Studies of Nucleosugar Modification Patterns

Hiroki Yamada, Hiroto Iwai, Fumitaka Hashiya, Yasuaki Kimura, Hiroshi Abe and Junichiro Yamamoto

ChemBioChem, 2025, 26
DOI: 10.1002/cbic.202400711

Trinucleotide cap analogs with triphosphate chain modifications: synthesis, properties, and evaluation as mRNA capping reagents

Marcin Warminski, Anais Depaix, Kamil Ziemkiewicz, Tomasz Spiewla, Joanna Zuberek, Karolina Drazkowska, Hanna Kedzierska, Agnieszka Popielec, Marek R Baranowski, Marta Sklucka, Marcelina Bednarczyk, Miroslaw Smietanski, Karol Wolosewicz, Bartosz Majewski, Remigiusz A Serwa, Dominika Nowis, Jakub Golab, Joanna Kowalska and Jacek Jemielity

Nucleic Acids Research, 2024, 52, 10788
DOI: 10.1093/nar/gkae763

Chemical Synthesis of Modified RNA

Laurin Flemmich, Raphael Bereiter and Ronald Micura

Angew Chem Int Ed, 2024, 63
DOI: 10.1002/anie.202403063

Chemical Synthesis of Modified RNA

Laurin Flemmich, Raphael Bereiter and Ronald Micura

Angewandte Chemie, 2024, 136
DOI: 10.1002/ange.202403063

Chemical Modifications of mRNA Ends for Therapeutic Applications

Marcin Warminski, Adam Mamot, Anaïs Depaix, Joanna Kowalska and Jacek Jemielity

Acc. Chem. Res., 2023, 56, 2814
DOI: 10.1021/acs.accounts.3c00442