Unravelling the cell death mechanism triggered by catalytic copper–iron nanoparticles in vitro and in vivo

Miguel Encinas-Gimenez, Ana Martín-Pardillos, Javier Bonet-Aleta, Estela Pérez, Ana Rodríguez-Largo, Jose L. Hueso, Jesus Santamaria and Pilar Martin-Duque

Nanoscale, 2025
DOI: 10.1039/D5NR01927C

Tempol alleviates acute lung injury by affecting glutathione synthesis through Nrf2 and inhibiting ferroptosis in lung epithelial cells

Li Ai, Ran Li, Xiaona Wang, Zhijuan Liu and Yongxia Li

J Biochem & Molecular Tox, 2024, 38
DOI: 10.1002/jbt.23674

Copper-based nanoplatforms and their role in cancer therapy

Jose I. Garcia-Peiro, Javier Bonet-Aleta and Jose L. Hueso

Coordination Chemistry Reviews, 2025, 534, 216542
DOI: 10.1016/j.ccr.2025.216542

Cocktail-Type Catalysis: An Emerging Concept in Metal-Mediated Transformations

Darya O. Prima and Sergey Z. Vatsadze

Organometallics, 2025, 44, 1337
DOI: 10.1021/acs.organomet.5c00117

A hollow-tube-like hydrospongel for multimodal therapy of advanced colorectal cancer

Tao Wu, Tenghui Li, Chengzhi Zhang, Yu Tian, Hao Li, Yuxin He, Xu Yan, Tianxing Gong, Junhua Zhao and Zhenning Wang

Nat Commun, 2025, 16
DOI: 10.1038/s41467-025-62880-x

Synergistic assembly of gold and copper-iron oxide nanocatalysts to promote the simultaneous depletion of glucose and glutathione

J. Bonet-Aleta, J.L. Hueso, L. Sanchez-Uriel, M. Encinas-Gimenez, S. Irusta, P. Martin-Duque, G. Martinez and J. Santamaria

Materials Today Chemistry, 2023, 29, 101404
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Laser-induced tuning of carbon nanosensitizers to maximize nitrogen doping and reactive oxygen species production in the visible range

Ainhoa Madrid, Gema Martinez, Felipe Hornos, Javier Bonet-Aleta, Esteban Calvo, Antonio Lozano and Jose L. Hueso

Catalysis Today, 2023, 422, 114214
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Tailored Metal-Based Catalysts: A New Platform for Targeted Anticancer Therapies

Maria Inês P. S. Leitão and Tânia S. Morais

J. Med. Chem., 2024, 67, 16967
DOI: 10.1021/acs.jmedchem.4c01680

Manganese oxide nano-platforms in cancer therapy: Recent advances on the development of synergistic strategies targeting the tumor microenvironment

Javier Bonet-Aleta, Javier Calzada-Funes and Jose L. Hueso

Applied Materials Today, 2022, 29, 101628
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Ultrathin 2D Pd/Cu Single‐Atom MOF Nanozyme to Synergistically Overcome Chemoresistance for Multienzyme Catalytic Cancer Therapy

Xiaowen Guan, Xiyang Ge, Hongliang Dong, Juanjuan Wei, Jin Ouyang and Na Na

Adv Healthcare Materials, 2023, 12
DOI: 10.1002/adhm.202301853

The Pattern of Copper Release in Copper‐Based Nanoparticles Regulates Tumor Proliferation and Invasiveness in 3D Culture Models

Jose I. Garcia‐Peiro, Paula Guerrero‐López, Felipe Hornos, Jose L. Hueso, J. Manuel Garcia‐Aznar and Jesus Santamaria

Small Science, 2024, 4
DOI: 10.1002/smsc.202400206

Nanoparticle-Catalyzed Transamination under Tumor Microenvironment Conditions: A Novel Tool to Disrupt the Pool of Amino Acids and GSSG in Cancer Cells

Javier Bonet-Aleta, Juan Vicente Alegre-Requena, Javier Martin-Martin, Miguel Encinas-Gimenez, Ana Martín-Pardillos, Pilar Martin-Duque, Jose L. Hueso and Jesus Santamaria

Nano Lett., 2024, 24, 4091
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Tumor-activated in situ synthesis of single-atom catalysts for O2-independent photodynamic therapy based on water-splitting

Yiyan Yin, Xiyang Ge, Jin Ouyang and Na Na

Nat Commun, 2024, 15
DOI: 10.1038/s41467-024-46987-1

Glutathione Threshold‐Triggered Selective Breakability of Organosilica Nanocapsules

Andrea Mosseri, Ana Rueda‐Flores, Jose L. Hueso, Esteban Urriolabeitia, Luisa De Cola and Jesus Santamaria

ChemCatChem, 2025
DOI: 10.1002/cctc.70141

Heterogeneous-Driven Glutathione Oxidation: Defining the Catalytic Role of Chalcopyrite Nanoparticles

Leticia Sanchez-Uriel, Javier Bonet-Aleta, Alfonso Ibarra and Jose L. Hueso

J. Phys. Chem. C, 2023, 127, 14146
DOI: 10.1021/acs.jpcc.3c00987

Nanomedical research and development in Spain: improving the treatment of diseases from the nanoscale

Paula Fernández-Gómez, Carmen Pérez de la Lastra Aranda, Carlota Tosat-Bitrián, Jesús Alejandro Bueso de Barrio, Sebastián Thompson, Begoña Sot, Gorka Salas, Álvaro Somoza, Ana Espinosa, Milagros Castellanos and Valle Palomo

Front. Bioeng. Biotechnol., 2023, 11
DOI: 10.3389/fbioe.2023.1191327

Nitrogen-doped carbon nanodots deposited on titania nanoparticles: Unconventional near-infrared active photocatalysts for cancer therapy

Ainhoa Madrid, Ana Martín-Pardillos, Javier Bonet-Aleta, Maria Sancho-Albero, Gema Martinez, Javier Calzada-Funes, Pilar Martin-Duque, Jesus Santamaria and Jose L. Hueso

Catalysis Today, 2023, 419, 114154
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Biomineralization of Copper‐Celastrol Nanohybrids for Synergistic Antitumor Therapy

Yifan Li, Na Wang, Hanrong Li, Xingyun Zhang, Liuxian Meng, Yingjie Yu, Shihui Wang and Li Deng

Small, 2025, 21
DOI: 10.1002/smll.202412802

A Highly‐Active Chemodynamic Agent Based on In Situ Generated Copper Complexes from Copper Hexacyanoferrate Nanoparticles

Javier Bonet‐Aleta, Jose L. Hueso, Angeles Valls‐Chiva, Iris Ruiz‐Aranda, Brenda Manzanilla, Jose I. Garcia‐Peiro, Sergio Aina, Esteban Urriolabeitia, Juan V. Alegre‐Requena and Jesus Santamaria

Small, 2025, 21
DOI: 10.1002/smll.202412355

Evolving Platinum‐Copper Nanostructures for Enhanced Photothermal Therapy and Controlled Copper Release in Cancer Therapy

Jose I. Garcia‐Peiro, María Sancho‐Albero, Silvia Miguel, Andrea Mosseri, Felipe Hornos, Rafael Contreras‐Montoya, Jose L. Hueso and Jesus Santamaria

Adv Funct Materials, 2025
DOI: 10.1002/adfm.202502999