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Zeylleucapenoids A–D, Highly Oxygenated Diterpenoids with Anti-Inflammatory Activity from Leucas zeylanica (L.) R. Br.

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Highly anticipated natural diterpenoids as an important source of new drugs in 2013–2023

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Divergent Syntheses of the Euphorbia Diterpenoids Pepluanol A and Pepluacetal

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Scandium-Catalyzed Voigt Condensation Enables One-Step Synthesis of Lathyranone-Type Nitrogen-Containing Euphorbia Diterpenoids from Lathyranes

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Myrsinane-Type Diterpenes: A Comprehensive Review on Structural Diversity, Chemistry and Biological Activities

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Chemical characterization of the crude extract of Sauromatum venosum (voodoo lily) and docking study with 12-O-acetylingol 8-tiglate for cytotoxicity testing in SaOS2 (osteoblastic osteosarcoma cells)

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Nature’s Green Potential: Anticancer Properties of Plants of the Euphorbiaceae Family

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Exploring anticancer properties of the phytoconstituents and comparative analysis of their chemical space parameters with USFDA‐approved synthetic anticancer agents

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Recent Advances in Ent-Abietane Diterpenes: Natural Sources, Biological Activities and Total Synthesis

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Targeted discovery of unusual diterpenoids with anti-fungal activity from the root of Euphorbia lathyris

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A Biomimetic Approach to Premyrsinane-Type Diterpenoids: Exploring Microbial Transformation to Enhance Their Chemical Diversity

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Diterpenoids from Euphorbia lactea and their anti-HIV-1 activity

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Lathyrane and ent-isopimarane diterpenoids from Euphorbia wallichii and target prediction of active ingredient

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Ingenane Diterpenoids from Euphorbia peplus as Potential New CHK1 Inhibitors That Sensitize Cancer Cells to Chemotherapy

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A green and simple method for enrichment of major diterpenoids from the buds of Wikstroemia chamaedaphne with macroporous resins and their activation of latent human immunodeficiency virus activity

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Three new abietane diterpenoids from the aerial parts of Euphorbia fischeriana and their cytotoxic effects

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Unexpected Main-Chain-Mediated and Neutral-Intermediate-Involved Catalytic Reaction in a High-Fidelity ent-Neoabietadiene Synthase

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Diels-Alder reaction: A versatile synthetic tool for the synthesis of terpenoids and alkaloids: A review

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Diterpenoids from Euphorbia fischeriana with Kv1.3 Inhibitory Activity

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Natural diterpene carrier-free hydrogel enhances antigen presentation and intensifies T cell activation for tumor immunotherapy

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Naturally Occurring Norsteroids and Their Design and Pharmaceutical Application

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Efficient NMR spectroscopy approach for the determination of the relative configuration of Δ5,6Δ11,12-jatrophane diterpenes and their chemotherapy sensitization activities

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Phytochemical study of the stems of Blachia siamensis (Euphorbiaceae)

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Chemical constituents of Euphorbia lathyris and their chemotaxonomic significance

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New diterpenoids from Euphorbia wallichii with antioxidant activity

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Skeleton Rearranged and Oxygenated ent‐Rosane Diterpenoids with Antiadipogenic Activity from Euphorbia milii

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Euphthymifolols A-E, anti-inflammatory jatrophane-type macrocyclic diterpenoids from Euphorbia thymifolia L

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Asymmetric Total Synthesis of Euphordraculoate A and Pedrolide

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Jatropadanes A-Q, lathyrane diterpenoids with lysosomal biogenesis potential from Jatropha podagrica Hook.

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Total Synthesis of (±)- and (+)-Euphohyrisnoid A

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Lathyrane and jatrophane diterpenoids: Potential lipid-lowering agents from Euphorbia helioscopia L

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Effect of lathyrane-type diterpenoids in neural stem cell physiology: Microbial transformations, molecular docking and dynamics studies

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Discovery of structurally intriguing diterpenoids as anti-neuroinflammatory agents from mangrove plant Excoecaria agallocha L. via inhibiting macrophage polarization and inflammasome

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Anti-inflammatory lanostane triterpenoids with rearranged spirobi[indene] scaffold and their biogenetically related analogues from Euphorbia maculata

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Total Synthesis of Euphorbialoid A

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Identification of two novel sesterterpene skeletons offers the first experimental evidence for the cyclization mechanism of mangicdiene synthase

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Nor-halimane and spiro-labdane diterpenoids with anti-inflammatory activity from Leucas ciliata Benth

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Enhancing Structural Diversity of Lathyrane Derivatives through Biotransformation by the Marine-Derived Actinomycete Streptomyces puniceus BC-5GB.11

Felipe Escobar-Montaño, Victoria E. González-Rodríguez, Antonio J. Macías-Sánchez, José M. Botubol-Ares, Rosa Durán-Patrón and Rosario Hernández-Galán

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A natural small molecule alleviates liver fibrosis by targeting apolipoprotein L2

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Brønsted Acid-Mediated Conversion of Naturally Abundant Lathyrane Diterpenes: Are Rare 10,11-seco-Lathyrane Diterpenes Artifacts?

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Photoinduced Radical Cyclization of 1,6‐Diynes: Rapid Access to Highly Substituted Carbocyclic and Heterocyclic Compounds

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Integration of LC/MS, NMR and Molecular Docking for Profiling of Bioactive Diterpenes from Euphorbia mauritanica L. with in Vitro Anti‐SARS‐CoV‐2 Activity

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Ent-atisane diterpenoids from Euphorbia wallichii and their anti-influenza A virus activity

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Biocatalyzed and Photochemical Formal [2+2] Cycloaddition of Euphoboetirane A: A Route to a Fused Pentacyclic Diterpene Skeleton

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Lathyrane diterpenoids from Euphorbia lathyris induce cell-cycle arrest and apoptosis in human hypertrophic scar cells

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Asymmetric Total Synthesis of Pedrolide

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Asymmetric Total Synthesis of Euphordraculoate A and Pedrolide

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Eupholine A and B, A Pair of Lathyrane Epimers with Inhibitory Activity of Fibrinogen from Euphorbia helioscopia L.

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Euphebranes A−G: higher diterpenoids from the radix of Euphorbia ebracteolata

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Strophioglandins A–C, highly rearranged norditerpenoids with an unusual tricyclo[6.4.1.04,13]tridecane core from Strophioblachia glandulosa var. cordifolia

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Ring contraction and ring expansion reactions in terpenoid biosynthesis and their application to total synthesis

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Rapid Access to Tigliane, Ingenane, and Rhamnofolane Diterpenes from a Lathyrane Precursor via Biomimetic Skeleton Transformation Strategy

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Euphorbia diterpenoids from Euphorbia peplus possessing anti-Alzheimer's activity via targeting PPARγ and upregulating the level of ABCA1

Yanlan Yang, Shoulun He, Yingting Lin, Junjie Chen, Renjing Yang, Xueli Li, Jingyu Sun, Guanghui Wang, Wenjing Tian and Haifeng Chen

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Biomimetic semi-synthesis, structural optimization and anti-HIV activity of naturally scarce eupholathone-, lathyranone- and integerrimine-type Euphorbia diterpenoids

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Glochodpurnoid B from Glochidion puberum Induces Endoplasmic Reticulum Stress-Mediated Apoptosis in Colorectal Cancer Cells

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Enantioselective Total Synthesis of (+)-Pedrolide

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Ir-Catalyzed Biomimetic Photoisomerization of Cyclopropane in Lathyrane-Type Euphorbia Diterpenes

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Yuexiandajisu diterpenoids from Euphorbia ebracteolata Hayata (Langdu roots): An overview

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Structurally diverse rhamnofolane, tigliane, and daphnane diterpenoids from Euphorbia wallichii as anti-liver fibrosis agents

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Applying click chemistry to discover the direct targets of the active components of traditional Chinese medicines

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Natural Sesquiterpenoids, Diterpenoids, Sesterterpenoids, and Triterpenoids with Intriguing Structures from 2017 to 2022

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Total Synthesis of Trigocherrins A and C

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Diterpenoids from Euphorbia lathyris L.: a comprehensive review update

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Casbane diterpenoids from Euphorbiaceae suppresse neuroinflammation by regulating microglia polarization via inhibiting NF-κB signaling

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Diterpenoids from Mangrove Plant Excoecaria agallocha L. and Their Anti-neuroinflammatory Activities

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Integrating metabolite-based molecular networking with database matching and LC-MS-guided targeted isolation for the discovery of novel chemical constituents: application to Euphorbia helioscopia L.

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Optimization of extraction, structural modification, and bioactivity of polysaccharides from Euphorbia trigona Mill. and their derivatives

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Jolkinolide B synergistically potentiates the antitumor activity of GPX4 inhibitors via inhibiting TrxR1 in cisplatin-resistant bladder cancer cells

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Strophiofimbrins A and B: Two Rearranged Norditerpenoids with Novel Tricyclic Carbon Skeletons from Strophioblachia fimbricalyx

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Exploring novel aromatase cytochrome P450-binding ligands: Molecular docking and QSAR study of phorbol esters as aromatase inhibitors

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Visible-Light-Promoted Tandem Thiol–Ene Click Reaction/Transannular Cyclization and Regioselective Cyclopropane Ring-Opening to Construct Sulfur-Containing Euphorbia Diterpenes

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Org. Lett., 2023, 25, 597
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An undescribed jatrophane diterpenoid along with known compounds from Euphorbia sororia with tumour multidrug resistance reversal ability

Hequn Yang, Dan Tang, Jiangyu Zhao and Haji Akber Aisa

Natural Product Research, 2025, 1
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Lathyrane and premyrsinane Euphorbia diterpenes against Alzheimer's disease: Bioinspired synthesis, anti-cholinesterase and neuroprotection bioactivity

Lian Sun, Xin-Ming Wang, Qianhui Tang, Yao Xiao, Jin-Bu Xu, Tong-Tong Zhang, Yan-Jun Liu, Xiaohuan Li and Feng Gao

Bioorganic Chemistry, 2024, 147, 107377
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Euphylonoids A and B, Two Highly Modified Jatrophane Diterpenoids with Potent Lipid-Lowering Activity from Euphorbia hylonoma

Shu-Qi Wu, Run-Zhu Fan, Fang-Yu Yuan, Wei Li, Dong Huang, Shen Li, Gui-Hua Tang, Zhi-Shu Huang and Sheng Yin

Org. Lett., 2022, 24, 8854
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Safety assessment of Brazilian medicinal plants used for inflammatory disorders: An integrative review

Rafael C. Matos, Ana F.A. Bitencourt, Vanessa R. Prado, Renes R. Machado and Marina Scopel

Pharmacological Research - Reports, 2026, 5, 100081
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Mining substrate-promiscuity cytochrome P450s from Euphorbia fischeriana for heterologous bioproduction of diverse labdane-related diterpenoids

Ke Gao, Lin Zhao, Lei Wang, Rui Zhang, Jianxun Zhu, Pengcheng Lin and Jiachen Zi

Chinese Chemical Letters, 2026, 37, 110903
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A small molecule targets LIC1 to suppress lung tumor growth by inducing autophagy

Jia-Luo Huang, Lei-Ming Wu, Shu-Qi Wu, Fang-Yu Yuan, Han-Zhuang Weng, Dong Huang, Lu Gan, Shuo-Bin Chen, Gui-Hua Tang and Sheng Yin

Nat Chem Biol, 2026, 22, 459
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Ingenane diterpenoids with anti-inflammatory activity from Euphorbia antiquorum

Ren-Fen Ma, Qian Wu, Yin-Po Pan, Hu Liu, Xin-Cheng Zhuang and Hua Zhang

Fitoterapia, 2025, 180, 106350
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Evolutionary Efforts in the Total Synthesis of Pepluacetal

Huilin Li, Meng Liu, Xingang Xie and Xuegong She

J. Org. Chem., 2025, 90, 10681
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Malbrumpenoids A-N, unusually cyclized triterpenoids from the Euphorbia endophyte Malbranchea umbrina D16

Shu-Qi Wu, Xinying Zhu, Fang-Yu Yuan, Han-Zhuang Weng, Lei Li, Dong Huang, Gui-Hua Tang and Sheng Yin

Chinese Chemical Letters, 2026, 37, 111336
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Catalytic Enantioselective Diels–Alder Reaction of Dienes with Acyclic and α,β- and β,β-Disubstituted Enones

Jan Samsonowicz-Górski, Santanu Ghosh, Nobuya Tsuji, Markus Leutzsch, Georg Breitenbruch, Nils Nöthling, Philip Kraft and Benjamin List

J. Am. Chem. Soc., 2025, 147, 39011
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Undescribed diterpenes from Euphorbia mauritanica L. as modulators of the breast cancer resistance: Mechanistic and in silico studies

Ahmed F. Essa, Mai M. Elghonemy, Rehab F. Taher, Rasha M. Allam and Abdelsamed I. Elshamy

Phytochemistry, 2025, 234, 114418
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Biomimetic Skeleton Conversion from Lathyrane into Euphoractine A-Type Euphorbia Diterpenes: Semisynthesis of Natural Diterpenes Euphoractins M and N

Si-Hao Deng, Jing Wang, Yi-Wen Ouyang, Fu-Lian Tang, Xiaohuan Li, Jin-Bu Xu and Feng Gao

Org. Lett., 2025, 27, 6947
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Discovery of Ingenane Diterpenoids from Euphorbia hylonoma as Antiadipogenic Agents

Shu-Qi Wu, Xinying Zhu, Tao Yuan, Fang-Yu Yuan, Shiyou Zhou, Dong Huang, Ying Wang, Gui-Hua Tang, Zhi-Shu Huang, Xin Chen and Sheng Yin

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Dimorpoloids A–D, Three Rearranged Diterpenoids and One Unique Daphnane-Type Diterpenoid from Dimorphocalyx poilanei

Shu-Shuai Chen, Yu-Han Chen, Cheng-Yu Zheng, Jian-Min Yue and Yao-Yue Fan

J. Org. Chem., 2025, 90, 9541
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Synthesis, antiproliferative and anti-MDR activities of lathyrane diterpene derivatives based on configuration inversion strategy

Yao Xiao, Wan-Sheng Ji, Wen-Ke Jin, Peng Wen, Lian-Hai Shan, Zong-Rui Hou, Xiao-Huan Li, Xian-Li Zhou, Yan-Jun Liu, Jin-Bu Xu and Feng Gao

Bioorganic Chemistry, 2023, 131, 106329
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Isolation of two novel terpenoid skeletons from Croton laui, an aromatic norsesterterpenoid and a highly rearranged neo-clerodane diterpenoid

Zong-Yi Zhang, Xin Wang, Ying Li, Yuan Gao, Yao-Yue Fan, Jian-Min Yue and Jin-Xin Zhao

Chinese Chemical Letters, 2026, 37, 110951
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