Inhibition of RAS-driven signaling and tumorigenesis with a pan-RAS monobody targeting the Switch I/II pocket

Lauren Wallon, Imran Khan, Kai Wen Teng, Akiko Koide, Mariyam Zuberi, Jianping Li, Gayatri Ketavarapu, Nathaniel J. Traaseth, John P. O’Bryan and Shohei Koide

Proc. Natl. Acad. Sci. U.S.A., 2022, 119
DOI: 10.1073/pnas.2204481119

New Insights on Pseudomonas Aeruginosa Exotoxin A-based Immunotoxins in Targeted Cancer Therapeutic Delivery

Radwa N Morgan, Sarra E Saleh, Hala A Farrag and Khaled M Aboshanab

Ther. Deliv., 2023, 14, 31
DOI: 10.4155/tde-2022-0055

Fluorescent labeling strategies for molecular bioimaging

Marcel Streit, Made Budiarta, Marvin Jungblut and Gerti Beliu

Biophysical Reports, 2025, 5, 100200
DOI: 10.1016/j.bpr.2025.100200

Non-Immunoglobulin Synthetic Binding Proteins for Oncology

Temitope I. David, Nikolay B. Pestov, Tatyana V. Korneenko and Nikolai A. Barlev

Biochemistry Moscow, 2023, 88, 1232
DOI: 10.1134/S0006297923090043

Design of Cell‐Penetrating Domain Antibodies via a Genetically Encoded β‐Lactam Amino Acid

Johnathan D. Rabb, Lucas E. Kruse and Qing Lin

Angew Chem Int Ed, 2025, 64
DOI: 10.1002/anie.202424076

Deletion Variants of Autotransporter from Psychrobacter cryohalolentis Increase Efficiency of 10FN3 Exposure on the Surface of Escherichia coli Cells

Lyudmila N. Shingarova, Lada E. Petrovskaya, Elena A. Kryukova, Sultan S. Gapizov, Elena F. Boldyreva, Dmitriy A. Dolgikh and Mikhail P. Kirpichnikov

Biochemistry Moscow, 2022, 87, 932
DOI: 10.1134/S0006297922090061

Cytosolic delivery of monobodies using the bacterial type III secretion system inhibits oncogenic BCR: ABL1 signaling

Chiara Lebon, Sebastian Grossmann, Greg Mann, Florian Lindner, Akiko Koide, Shohei Koide, Andreas Diepold and Oliver Hantschel

Cell Commun Signal, 2024, 22
DOI: 10.1186/s12964-024-01874-6

Non-immunoglobulin synthetic binding proteins for oncology

T. I David, N. B Pestov, T. V Korneenko and N. A Barlev

Biohimiâ, 2023, 88, 1493
DOI: 10.31857/S032097252309004X

Protein-Based Degraders: From Chemical Biology Tools to Neo-Therapeutics

Lisha Ou, Mekedlawit T. Setegne, Jeandele Elliot, Fangfang Shen and Laura M. K. Dassama

Chem. Rev., 2025, 125, 2120
DOI: 10.1021/acs.chemrev.4c00595

Programmable Proteins: Target Specificity, Programmability and Future Directions

Masahito Yamagata

SynBio, 2022, 1, 65
DOI: 10.3390/synbio1010005

Inhibition and degradation of NRAS with a pan-NRAS monobody

Michael Whaby, Gayatri Ketavarapu, Akiko Koide, Megan Mazzei, Mubashir Mintoo, Eliezra Glasser, Unnatiben Patel, Cecile Nasarre, Matthew J. Sale, Frank McCormick, Shohei Koide and John P. O’Bryan

Oncogene, 2024, 43, 3489
DOI: 10.1038/s41388-024-03186-y

Monobody Inhibitor Selective to the Phosphatase Domain of SHP2 and its Use as a Probe for Quantifying SHP2 Allosteric Regulation

Fern Sha, Kohei Kurosawa, Eliezra Glasser, Gayatri Ketavarapu, Samara Albazzaz, Akiko Koide and Shohei Koide

Journal of Molecular Biology, 2023, 435, 168010
DOI: 10.1016/j.jmb.2023.168010

Methodological and regulatory aspects of pharmaceutical development of biological products

D. V. Kurkin, E. I. Morkovin, D. A. Bakulin, A. V. Zaborovsky, I. E. Makarenko, R. V. Drai, A. G. Solodovnikov, V. I. Petrov, K. N. Koryanova, N. A. Lycheva, S. A. Voskresensky, A. V. Strygin, Yu. A. Kolosov, Yu. V. Gorbunova and O. V. Ivanova

Farm. farmakol. (Pâtigorsk), 2024, 11, 384
DOI: 10.19163/2307-9266-2023-11-5-384-398

Exploring switch II pocket conformation of KRAS(G12D) with mutant-selective monobody inhibitors

Padma Akkapeddi, Takamitsu Hattori, Imran Khan, Eliezra Glasser, Akiko Koide, Gayatri Ketavarapu, Michael Whaby, Mariyam Zuberi, Kai Wen Teng, Julia Lefler, Lorenzo Maso, Injin Bang, Michael C. Ostrowski, John P. O’Bryan and Shohei Koide

Proc. Natl. Acad. Sci. U.S.A., 2023, 120
DOI: 10.1073/pnas.2302485120

The Peptide PROTAC Modality: A New Strategy for Drug Discovery

Youmin Zhu, Yu Dai and Yuncai Tian

MedComm, 2025, 6
DOI: 10.1002/mco2.70133

Adaptor-Specific Antibody Fragment Inhibitors for the Intracellular Modulation of p97 (VCP) Protein–Protein Interactions

Ziwen Jiang, Yu-Hsuan Kuo, Mengqi Zhong, Jianchao Zhang, Xin X. Zhou, Lijuan Xing, James A. Wells, Yanzhuang Wang and Michelle R. Arkin

J. Am. Chem. Soc., 2022, 144, 13218
DOI: 10.1021/jacs.2c03665

Design of Cell‐Penetrating Domain Antibodies via a Genetically Encoded β‐Lactam Amino Acid

Johnathan D. Rabb, Lucas E. Kruse and Qing Lin

Angewandte Chemie, 2025, 137
DOI: 10.1002/ange.202424076