Traditional Chinese medicine and gut microbiota: biotransformation, interaction, and implications for chronic disease treatment

Xia Hao, Jinbo Zhang, Ruishuang Ma, Bin Yao and Wei Yang

Drug Metabolism Reviews, 2025, 1
DOI: 10.1080/03602532.2025.2520768

Baicalin Inhibits Airway Smooth Muscle Cells Proliferation through the RAS Signaling Pathway in Murine Asthmatic Airway Remodeling Model

Lingli Hu, Lulu Li, Chen Yan, Yuxue Cao, Xiaohong Duan, Jing Sun and Qiongming Xu

Oxidative Medicine and Cellular Longevity, 2023, 2023, 1
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Intestinal microbiota analysis and network pharmacology reveal the mechanism by which Lianhua Qingwen capsule improves the immune function of mice infected with influenza A virus

Ping Xu, Zhu Yang, Shuangqiu Du, Zongyuan Hong and Shuzhi Zhong

Front. Microbiol., 2022, 13
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Radix Isatidis polysaccharide (RIP) alleviates QX-genotype infectious bronchitis virus-induced interstitial nephritis through the Nrf2/NLRP3/Caspase-3 signaling pathway

Xuelian Xiang, Yamei Huang, Yuxi Shen, Jiadai Lv, Wenwen Li, Mengyi Dong, Yi Sun, Jing Xu, Min Cui, Yong Huang and Jing Xia

International Journal of Biological Macromolecules, 2024, 278, 134571
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The Interaction between Flavonoids and Intestinal Microbes: A Review

Hui-Hui Xiong, Su-Yun Lin, Ling-Li Chen, Ke-Hui Ouyang and Wen-Jun Wang

Foods, 2023, 12, 320
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Qing-Kai-Ling oral liquid alleviated pneumonia via regulation of intestinal flora and metabolites in rats

Hongying Chen, Siju Li, Biyan Pan, Kun Liu, Hansheng Yu, Chong Ma, Huiyuan Qi, Yuefeng Zhang, Xinyi Huang, Dongsheng Ouyang and Zhiyong Xie

Front. Microbiol., 2023, 14
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A Review on the Application of Traditional to Modern Approaches of Chinese Herbal Veterinary Medicines: Current Status and Challenges

Fangbing Xu, Yecheng Yao, Yifan Li, Weiming Wang, Zhiyong Wu and Xuelin Zhou

Journal of Food Biochemistry, 2024, 2024
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The Research Progress on the Interaction between Mammalian Gut Microbiota and the Host’s Metabolism Homeostasis during Hibernation

Zhepei Zhang, Fengcheng Song, Linjuan Wang and Zhengrong Yuan

Metabolites, 2024, 14, 134
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Dietary flavonoids modulate the gut microbiota: A new perspective on improving autism spectrum disorder through the gut-brain axis

Haochen Dai, Yuhan Jiang, Shuxun Liu, Dandan Li and Xin Zhang

Food Research International, 2024, 186, 114404
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Research advances in polyphenols from Chinese herbal medicine for the prevention and treatment of chronic obstructive pulmonary disease: a review

Yang Zhang, Lijuan Wang, Jinyi Zeng and Wen Shen

Naunyn-Schmiedeberg's Arch Pharmacol, 2025
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The gut-lung axis in severe acute Pancreatitis-associated lung injury: The protection by the gut microbiota through short-chain fatty acids

Zhengjian Wang, Jin Liu, Fan Li, Yalan Luo, Peng Ge, Yibo Zhang, Haiyun Wen, Qi Yang, Shurong Ma and Hailong Chen

Pharmacological Research, 2022, 182, 106321
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Intervention Effects of Okra Extract on Brain-Gut Peptides and Intestinal Microorganisms in Sleep Deprivation Rats

Jingru Wu, Mingxue Cao, Ming Hu, Yu Gong, Jianming Xue, Yilin Yang, Hairui Zhou and Duygu Ağagündüz

Evidence-Based Complementary and Alternative Medicine, 2022, 2022, 1
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The role of fatty acid metabolism in acute lung injury: a special focus on immunometabolism

Xiao Lu, Guorui Li, Yi Liu, Guoqing Luo, Song Ding, Tianyu Zhang, Ning Li and Qing Geng

Cell. Mol. Life Sci., 2024, 81
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Microbiota, metabolites and mucosal immunity as potential targets of traditional Chinese medicine for respiratory diseases based on the lung-gut crosstalk

Wei Wang, Shaoqing Zhu, Yuanbin Zhang, Lin Chu, Siyao Liu, Huan Yang and Hao Wu

Pharmacological Research - Modern Chinese Medicine, 2024, 10, 100374
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Purification, characterization, simulated gastrointestinal digestion and gut microbiota fermentation of a Bifidobacterium-directed mannoglucan from Lilium brownii var. viridulum

Guangjian Bai, Miaoyun Ye, Li Yu, Ming Yang, Yaqi Wang and Shaodan Chen

Food Chemistry: X, 2024, 23, 101671
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Dietary flavonoids and gut microbiota interaction: A focus on animal and human studies to maximize their health benefits

Li Yang, Yongchao Gao, Mohamed A. Farag, Jupeng Gong, Qiaoling Su, Hui Cao, Wei Zhang, Yonghua Zhao and Hui Wang

Food Frontiers, 2023, 4, 1794
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Microbiome and metabolome reveal beneficial effects of baicalin on broiler growth performance and intestinal health

Xingbo Liu, Yunru Ji, Huiyuan Lv, Zengpeng Lv, Yuming Guo and Wei Nie

Poultry Science, 2025, 104, 104678
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“Key Factor” for Baijiu Quality: Research Progress on Acid Substances in Baijiu

Yashuai Wu, Yaxin Hou, Hao Chen, Junshan Wang, Chunsheng Zhang, Zhigang Zhao, Ran Ao, He Huang, Jiaxin Hong, Dongrui Zhao and Baoguo Sun

Foods, 2022, 11, 2959
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Scutellaria baicalensis water decoction ameliorates lower respiratory tract infection by modulating respiratory microbiota

Yanqin Luo, Bo Lin, Peng Yu, Di Zhang, Yingfan Hu, Xianli Meng and Li Xiang

Phytomedicine, 2024, 129, 155706
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Mechanisms of Baicalin Alleviates Intestinal Inflammation: Role of M1 Macrophage Polarization and Lactobacillus amylovorus

Shunfen Zhang, Ruqing Zhong, Miao Zhou, Kai Li, Huiyuan Lv, Huixin Wang, Ye Xu, Dadan Liu, Qiugang Ma, Liang Chen and Hongfu Zhang

Advanced Science, 2025, 12
DOI: 10.1002/advs.202415948

Baicalin enhances antioxidant, inflammatory defense, and microbial diversity of yellow catfish (Pelteobagrus fulvidraco) infected with Aeromonas hydrophila

Pupu Yan, Jiali Liu, Yongxi Huang, Tilin Yi, Heng Zhang, Gang Dai, Xiong Wang, Zhenzhen Gao, Bin He, Weili Guo, Yingbing Su and Liwei Guo

Front. Microbiol., 2024, 15
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Gegen Qinlian tablets delay Alzheimer's disease progression via inhibiting glial neuroinflammation and remodeling gut microbiota homeostasis

Lin Wang, Ye Lu, Jiamei Liu, Siyi Wang, Zepeng Fei, Kaiwen Zhang, Dongfang Zhang and Xin Jin

Phytomedicine, 2024, 128, 155394
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Probiotic cocktails accelerate baicalin metabolism in the ileum to modulate intestinal health in broiler chickens

Mingkun Gao, Chaoyong Liao, Jianyang Fu, Zhonghua Ning, Zengpeng Lv and Yuming Guo

J Animal Sci Biotechnol, 2024, 15
DOI: 10.1186/s40104-023-00974-6

Baicalin attenuates acute skin damage induced by ultraviolet B via inhibiting pyroptosis

Zuohao Liu, Bingrong Dang, Zhen Li, Xingsheng Wang, Yuhan Liu, Fen Wu, Xinhui Cao, Chunming Wang and Changjun Lin

Journal of Photochemistry and Photobiology B: Biology, 2024, 256, 112937
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Impact of natural compounds on peroxisome proliferator-activated receptor: Molecular effects and its importance as a novel therapeutic target for neurological disorders

Zhe Zhu, Yadi Guan, Songlan Gao, Feng Guo, Dong Liu and Honglei Zhang

European Journal of Medicinal Chemistry, 2025, 283, 117170
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Recent advances on the regulation of bacterial biofilm formation by herbal medicines

Meimei Zhang, Wenyu Han, Jingmin Gu, Cao Qiu, Qiujie Jiang, Jianbao Dong, Liancheng Lei and Fengyang Li

Front. Microbiol., 2022, 13
DOI: 10.3389/fmicb.2022.1039297

Evolving interplay between natural products and gut microbiota

Ning-Ning Zhang, Zheng-Meng Jiang, Shang-Zhen Li, Xing Yang and E-Hu Liu

European Journal of Pharmacology, 2023, 949, 175557
DOI: 10.1016/j.ejphar.2023.175557

Baicalin Prevents Colon Cancer by Suppressing CDKN2A Protein Expression

Gang-gang Li, Xiu-feng Chu, Ya-min Xing, Xia Xue, Bukhari Ihtisham, Xin-feng Liang, Ji-xuan Xu, Yang Mi and Peng-yuan Zheng

Chin. J. Integr. Med., 2024, 30, 1007
DOI: 10.1007/s11655-024-4109-6

Baicalin promotes appetite by regulating gut microbiome and immunity?

Shunfen Zhang, Huiyuan Lv, Ruqing Zhong, Shanlong Tang, Hui Han, Xueying Cai, Liang Chen and Hongfu Zhang

Journal of Functional Foods, 2023, 105, 105557
DOI: 10.1016/j.jff.2023.105557

Combined analysis of the microbiome, metabolome and transcriptome of silkie chickens in response to avian pathogenic E. coli (APEC)

Wenqing Li, Wanli Li, Qinghan Zhao, Pinhui Wu, Xinmeng Huang, Wei Jin, Bingxun Wang, Shengli Li, Wei Liu, Guozhi Zhang and Xiangtao Kang

Microbial Pathogenesis, 2024, 189, 106586
DOI: 10.1016/j.micpath.2024.106586

Rujin Jiedu decoction protects against influenza virus infection by modulating gut microbiota

Qilin Huang, Guizhen Yang, Chenchen Tang, Biao Dou, You Hu, Hui Liu, Xiao Wu, Huan Zhang, Haikun Wang, Lirong Xu, Xiao-Dong Yang, Yanwu Xu and Yuejuan Zheng

Heliyon, 2024, 10, e34055
DOI: 10.1016/j.heliyon.2024.e34055

Fecal microbiota transplantation from HUC-MSC-treated mice alleviates acute lung injury in mice through anti-inflammation and gut microbiota modulation

Feng Hua, Enhai Cui, Lu Lv, Bin Wang, Liqin Li, Huadong Lu, Na Chen and Wenyan Chen

Front. Microbiol., 2023, 14
DOI: 10.3389/fmicb.2023.1243102

Peroxisome proliferator-activated receptors (PPARs) agonists as promising neurotherapeutics

Iman A.Y. Ghannam, Rasha M. Hassan and Mohammed S. Abdel-Maksoud

Bioorganic Chemistry, 2025, 156, 108226
DOI: 10.1016/j.bioorg.2025.108226

Effect of flavonoids on neurodegenerative diseases caused by acrylamide: Based on the perspective of intestinal flora

Xing Ge, Yidan Cai, Haochen Dai, Yuhan Jiang, Songmei Luo, Xin Zhang and Yuchen Zhu

Journal of Future Foods, 2026, 6, 173
DOI: 10.1016/j.jfutfo.2024.09.003

Short-Chain Fatty Acid (SCFA) as a Connecting Link between Microbiota and Gut-Lung Axis─A Potential Therapeutic Intervention to Improve Lung Health

Anjali Verma, Tannu Bhagchandani, Ankita Rai, Nikita, Urvinder Kaur Sardarni, Neel Sarovar Bhavesh, Sameer Gulati, Rupali Malik and Ravi Tandon

ACS Omega, 2024, 9, 14648
DOI: 10.1021/acsomega.3c05846

Traditional Chinese medicine to improve immune imbalance of asthma: focus on the adjustment of gut microbiota

Ke Lu, Chen Li, Jingwen Men, Bin Xu, Yang Chen, Peizheng Yan, Zhibo Gai, Qingxiang Zhang and Lu Zhang

Front. Microbiol., 2024, 15
DOI: 10.3389/fmicb.2024.1409128

Bacteriostatic Effects of Yujin Powder and Its Components on Clinical Isolation of Multidrug-Resistant Avian Pathogenic Escherichia coli

Jinwu Meng, Jinli Wang, Jinyue Zhu, Siya Li, Tianxin Qiu, Weiran Wang, Jinxue Ding, Wenjia Wang and Jiaguo Liu

Veterinary Sciences, 2023, 10, 328
DOI: 10.3390/vetsci10050328

Interactions between gut microbiota and polyphenols: A mechanistic and metabolomic review

Hao Cheng, Dandan Zhang, Jing Wu, Juan Liu, Yaochuan Zhou, Yuzhu Tan, Wuwen Feng and Cheng Peng

Phytomedicine, 2023, 119, 154979
DOI: 10.1016/j.phymed.2023.154979

Baicalin Promotes Skeletal Muscle Fiber Remodeling by Activating the p38MAPK/PGC-1α Signaling Pathway

Teng Wang, Xiaohui Sun, Yidi Zhang, Qingyan Wang, Wenhui Cheng, Yuhui Gao, Xin’e Shi and Jianjun Jin

J. Agric. Food Chem., 2025, 73, 6878
DOI: 10.1021/acs.jafc.5c00300

A novel formula of herbal extracts regulates growth performance, antioxidant capacity, intestinal microbiota and resistance against Aeromonas veronii in largemouth bass (Micropterus salmoides)

Chen Bin Zhu, Yi Ting Shen, Chu Heng Ren, Shun Yang and Hui Fei

Aquaculture, 2024, 583, 740614
DOI: 10.1016/j.aquaculture.2024.740614

Integrated Transcriptome Analysis Reveals the Lung miRNA–mRNA Regulatory Network Associated with Avian Pathogenic E. coli Infection

Huan Li, Jishuang Tan, Xiaoyi Li, Susan J. Lamont and Hongyan Sun

Veterinary Sciences, 2025, 12, 95
DOI: 10.3390/vetsci12020095

Research progress on pharmacological effects and new dosage forms of baicalin

Minglong Bao, Yunfei Ma, Mei Liang, Xinyi Sun, Xianghong Ju, Yanhong Yong and Xiaoxi Liu

Veterinary Medicine & Sci, 2022, 8, 2773
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Baicalin: an active natural product with potential medicinal values

Yong-Qiang Wen, Ya-Zhou Wang, Chen-Xu Zhao, Bao-Yu Zhao and Jian-Guo Wang

Journal of Asian Natural Products Research, 2025, 27, 1087
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Potential herb–drug interactions between anti-COVID-19 drugs and traditional Chinese medicine

Ling Ye, Shicheng Fan, Pengfei Zhao, Chenghua Wu, Menghua Liu, Shuang Hu, Peng Wang, Hongyu Wang and Huichang Bi

Acta Pharmaceutica Sinica B, 2023, 13, 3598
DOI: 10.1016/j.apsb.2023.06.001