Bifidobacterium longum relieves constipation by regulating the intestinal barrier of mice

Linlin Wang, Mao Chai, Jialiang Wang, Qiangqing YU, Gang Wang, Hao Zhang, Jianxin Zhao and Wei Chen

Food Funct., 2022, 13, 5037
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Different effects of Bacillus coagulans vegetative cells and spore isolates on constipation-induced gut microbiota dysbiosis in mice

Liuruolan Li, Bingshu Liu, Jiang Cao, Hao Zhang, Fengwei Tian, Leilei Yu, Wei Chen and Qixiao Zhai

Food Funct., 2022, 13, 9645
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Integrated metabolic profiles and microbial communities to reveal the beneficial effect of red pitaya on early constipation

Pengfei Zhao, Xiran Meng, Mo Sun, Bingqing Qin, Shuaiwen Kong, Lixia Xie, Wei Zhang, Xudong Ding and Chenning Zhang

Food Funct., 2024, 15, 5414
DOI: 10.1039/D4FO00007B

Lycopene regulates intestinal dysmotility and behavioral disorders by regulating enteric neurons and the cholinergic system

Danna Wang, Siyi Jiao, Qianqian Guo, Mengnan Zhou, Wanting Ren, Yuqi Zhao, Dongning Li, Wenyue Yang, Shengquan Dai, Yanqian Pei, Danyixin Xiao, Xuebo Liu, Chunxia Xiao and Beita Zhao

Food Funct., 2025, 16, 5363
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Integrated metabolomics and transcriptomics revealed the anti-constipation mechanisms of xylooligosaccharides from corn cobs

Hong Song, Rui Guo, Xianbao Sun, Yuxing Kou, Xuan Ma, Yinan Chen, Lihua Song and Yan Wu

Food Funct., 2024, 15, 894
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Xylooligosaccharides from corn cobs alleviate loperamide-induced constipation in mice via modulation of gut microbiota and SCFA metabolism

Hong Song, Rui Guo, Xianbao Sun, Yuxing Kou, Xuan Ma, Yinan Chen, Lihua Song, Chunmei Yuan and Yan Wu

Food Funct., 2023, 14, 8734
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Bifidobacterium longum subsp. longum relieves loperamide hydrochloride-induced constipation in mice by enhancing bile acid dissociation

Chenyue Zhang, Linlin Wang, Xiaoming Liu, Gang Wang, Jianxin Zhao and Wei Chen

Food Funct., 2025, 16, 297
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Weissella confusa WIKIM51 (Wilac D001) improves constipation and gut health in a loperamide-induced mouse model

Dan-Bi Ki, Jong-Yeon Kim, Varun Jaiswal, Byung Wook Lee, Sang Min Park, Eun-Jung Park and Hae-Jeung Lee

Food Funct., 2025
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Lactobacillus rhamnosus GG supernatant promotes intestinal mucin production through regulating 5-HT4R and gut microbiota

Yu Gu, Xiali Qin, Guoqiong Zhou, Chen Wang, Chenlu Mu, Xiang Liu, Weilong Zhong, Xin Xu, Bangmao Wang, Kui Jiang, Jinghua Liu and Hailong Cao

Food Funct., 2022, 13, 12144
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Bifidobacterium bifidum CCFM1359 alleviates intestinal motility disorders through the BDNF-TrkB pathway

Linlin Wang, Liping Cao, Qiangqing Yu, Mengxia Liang, Zhichao Yang, Gang Wang, Jianxin Zhao and Wei Chen

Food Funct., 2025, 16, 437
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Exploring the Dose–Effect Relationship of Bifidobacterium longum in Relieving Loperamide Hydrochloride-Induced Constipation in Rats through Colon-Released Capsules

Xin Zhou, Bingyong Mao, Xin Tang, Qiuxiang Zhang, Jianxin Zhao, Hao Zhang and Shumao Cui

IJMS, 2023, 24, 6585
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Lactobacillus paracasei Relieves Constipation by Acting on the Acetic Acid-5-HT-Intestinal Motility Pathway

Linlin Wang, Shurong Yang, Chunxia Mei, Nan Tang, Jialiang Wang, Qiangqing Yu, Gang Wang, Gaojue Wu, Jianxin Zhao and Wei Chen

Foods, 2023, 12, 4176
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Effects of food-grade iron(III) oxide nanoparticles on cecal digesta- and mucosa-associated microbiota and short-chain fatty acids in rats

Jiangchun SHI, Yumeng XIE, Yulin LI, Dongxia REN, Yiqi ZHANG, Huangfang SHAO, Yang LIU, Xue WANG and Yun LI

Bioscience of Microbiota, Food and Health, 2024, 43, 43
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Seasonal differences in intestinal flora are related to rats’ intestinal water metabolism

Jing Li, Yike Sun, Ruochong Wang, Shuran Ma, Lei Shi, Kai Wang, Hairong Zhang, Tong Wang and Leilei Liu

Front. Microbiol., 2023, 14
DOI: 10.3389/fmicb.2023.1109696

The Anti-Constipation Effects of Raffino-Oligosaccharide on Gut Function in Mice Using Neurotransmitter Analyses, 16S rRNA Sequencing and Targeted Screening

Yuxuan Liang, Yu Wang, Peng Wen, Yongchun Chen, Dongmei Ouyang, Da Wang, Bin Zhang, Jie Deng, Yanhong Chen, Yuanming Sun and Hong Wang

Molecules, 2022, 27, 2235
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Alleviation of loperamide‐induced constipation with sticky rice fermented huangjiu by the regulation of serum neurotransmitters and gut microbiota

Xinjing Feng, Ying Shi, Zhilei Zhou, Zhongwei Ji, Weibiao Zhou, Shuguang Chen and Jian Mao

J Sci Food Agric, 2023, 103, 692
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Defatted hempseed meal altered the metabolic profile of fermented yogurt and enhanced the ability to alleviate constipation in rats

Jiaxin Xu, Xinyue Xu, Dong Hua, Zhiheng Yuan, Miao Bai, Hong Song, Lina Yang, Jifeng Li, Danshi Zhu and He Liu

J Sci Food Agric, 2023, 103, 4778
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Lacticaseibacillus rhamnosus Glory LG12 preventives loperamide-induced constipation in mice by modulating intestinal flora and metabolic pathways

Weiwei Ma, Lian Lian, Lidong Guo, Yanan Wu and Lili Huang

Front. Microbiol., 2025, 16
DOI: 10.3389/fmicb.2025.1577799

2′-Fucosyllactose synbiotics with Bifidobacterium bifidum to improve intestinal transcriptional function and gut microbiota in constipated mice

Yi Shan, Miaomiao Zheng, Weiwei Liang, Le Ouyang and Shumei Wang

Food Research International, 2025, 217, 116840
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Fu Brick Tea Alleviates Constipation via Regulating the Aquaporins-Mediated Water Transport System in Association with Gut Microbiota

Bangran Qi, Yuanyuan Zhang, Daoyuan Ren, Xinshu Qin, Nan Wang and Xingbin Yang

J. Agric. Food Chem., 2023, 71, 3862
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Crosstalk between the Gut Microbiome and Colonic Motility in Chronic Constipation: Potential Mechanisms and Microbiota Modulation

Ruili Pan, Linlin Wang, Xiaopeng Xu, Ying Chen, Haojue Wang, Gang Wang, Jianxin Zhao and Wei Chen

Nutrients, 2022, 14, 3704
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Lactic acid bacteria in relieving constipation: mechanism, clinical application, challenge, and opportunity

Tong Zhang, Wenxu Liu, Huimin Lu, Ting Cheng, Linlin Wang, Gang Wang, Hao Zhang and Wei Chen

Critical Reviews in Food Science and Nutrition, 2025, 65, 551
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Lactobacillus reuteri CCFM1175 and Lactobacillus paracasei CCFM1176 Could Prevent Capsaicin-Induced Ileal and Colonic Injuries

Bingyong Mao, Qunran Xiang, Xin Tang, Qiuxiang Zhang, Xiaoming Liu, Jianxin Zhao, Shumao Cui and Hao Zhang

Probiotics & Antimicro. Prot., 2023, 15, 797
DOI: 10.1007/s12602-023-10106-1

Modulation of gut microbiota ecosystem by a glucan-rich snail mucin heteropolysaccharide attenuates loperamide-induced constipation

Hoon Kim, Eun-Jin Jeong, Chunwoong Park, Jeong-seok Lee, Woo Jung Kim, Kwang-Won Yu, Hyung Joo Suh, Yejin Ahn and Sung-Kwon Moon

International Journal of Biological Macromolecules, 2023, 253, 126560
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Consumption of Wheat Peptides Improves Functional Constipation: A Translational Study in Humans and Mice

Qianqian Wang, Fei Shen, Junhui Zhang, Haiying Cai, Ya Pan, Tengjia Sun, Yihang Gong, Juan Du, Hao Zhong and Fengqin Feng

Molecular Nutrition Food Res, 2022, 66
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Lacticaseibacillus paracasei NCU-04 relieves constipation and the depressive-like behaviors induced by loperamide in mice through the microbiome-gut-brain axis

Shengjie Li, Yi Li, Yujie Cai, Zizhou Yan, Jing Wei, Hongyan Zhang, Fenfang Yue and Tingtao Chen

Current Research in Food Science, 2024, 9, 100875
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Dextran sodium sulfate-induced colitis alters the proportion and composition of replicating gut bacteria

Eve T. Beauchemin, Claire Hunter, Corinne F. Maurice and Vincent B. Young

mSphere, 2025, 10
DOI: 10.1128/msphere.00825-24

Bifidobacterium bifidum CCFM1163 Alleviated Cathartic Colon by Regulating the Intestinal Barrier and Restoring Enteric Nerves

Nan Tang, Qiangqing Yu, Chunxia Mei, Jialiang Wang, Linlin Wang, Gang Wang, Jianxin Zhao and Wei Chen

Nutrients, 2023, 15, 1146
DOI: 10.3390/nu15051146

Wheat peptides with different hydrolysis degree have similar relief effect in constipated mice

Qianqian Wang, Fei Shen, Junhui Zhang, Jiachen Zhuang and Fengqin Feng

Food Bioscience, 2023, 52, 102459
DOI: 10.1016/j.fbio.2023.102459

Therapeutic Mechanism of Zhuyang Tongbian Decoction in Treating Functional Constipation: Insights from a Pilot Study Utilizing 16S rRNA Sequencing, Metagenomics, and Metabolomics

Xuan Zhang, Hang Yin, Xu Yang, Jie Kang and Nan Sui

IJGM, 2025, Volume 18, 1007
DOI: 10.2147/IJGM.S509592

Efficacy of Lacticaseibacillus paracasei fermented milk on a model of constipation induced by loperamide hydrochloride in BALB/c mice

Cheng Xue, Ming Li, Min Luo, Baoping Zhang and Yifan Wang

Journal of Food Science, 2024, 89, 6733
DOI: 10.1111/1750-3841.17338

The Different Ways Multi-Strain Probiotics with Different Ratios of Bifidobacterium and Lactobacillus Relieve Constipation Induced by Loperamide in Mice

Chenyue Zhang, Linlin Wang, Xiaoming Liu, Gang Wang, Xinmei Guo, Xuecong Liu, Jianxin Zhao and Wei Chen

Nutrients, 2023, 15, 4230
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Efficacy of a postbiotic and its components in promoting colonic transit and alleviating chronic constipation in humans and mice

Teng Ma, Yalin Li, Ni Yang, Huan Wang, Xuan Shi, Yanfang Liu, Hao Jin, Lai-Yu Kwok, Zhihong Sun and Heping Zhang

Cell Reports Medicine, 2025, 6, 102093
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Combined Omics Analysis Further Unveils the Specific Role of Butyrate in Promoting Growth in Early-Weaning Animals

Bin Zhang, Mengqi Liu, Zhengkai Yue, Xiaoyang Chen, Chenyang Li, Lei Liu and Fuchang Li

IJMS, 2023, 24, 1787
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Multi-omics reveals the mechanisms underlying Lactiplantibacillus plantarum P8-mediated attenuation of oxidative stress in broilers challenged with dexamethasone

Jinshan Zhao, Fan Zhao, Xuemin Li, Junmeng Yuan, Kai Zhang, Huawei Liu and Yang Wang

Animal Nutrition, 2023, 14, 281
DOI: 10.1016/j.aninu.2023.06.002

Effect of Bifidobacterium animalis subsp. lactis SF on enhancing the tumor suppression of irinotecan by regulating the intestinal flora

Zhongyue Ren, Shufang Chen, Huihui Lv, Lingling Peng, Wanyu Yang, Jiahui Chen, Zhihua Wu and Cuixiang Wan

Pharmacological Research, 2022, 184, 106406
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Brain-bacteria-gut axis and oxidative stress mediated by intestinal mucosal microbiota might be an important mechanism for constipation in mice

Xin Yi, Kang Zhou, Ping Jiang, Na Deng, Xinxin Peng and Zhoujin Tan

3 Biotech, 2023, 13
DOI: 10.1007/s13205-023-03580-5

Runchangningshen paste activates NLRP6 inflammasome-mediated autophagy to stimulate colonic mucin-2 secretion and modulates mucosal microbiota in functional constipation

Xue-Jiao Liu, Ye-li-ya Ye-er-tai, Yue-Bo Jia, Chen-Heng Wu, Xiang-Xiang Wang, Ke-Ming Yang, Xuan Yao and Jiang-Hong Ling

World J Gastroenterol, 2025, 31
DOI: 10.3748/wjg.v31.i9.102256

Xiao Cheng Qi Decoction, an Ancient Chinese Herbal Mixture, Relieves Loperamide-Induced Slow-Transit Constipation in Mice: An Action Mediated by Gut Microbiota

Amanguli Tuohongerbieke, Huaiyou Wang, Jiahui Wu, Zhengqi Wang, Tingxia Dong, Yamiao Huang, Dequan Zhu, Dongmei Sun and Karl Wah Keung Tsim

Pharmaceuticals, 2024, 17, 153
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Bifidobacterium bifidum CCFM1163 Alleviates Cathartic Colon Through the Acetate/Propionate‐GPR41‐Gβγ Pathway

Yin Huang, Nan Tang, Yifan Xue, Jiazhen Li, WenXu Liu, Shengnan Zhu, Linlin Wang, Gang Wang, Wei Chen and Jianxin Zhao

Food Frontiers, 2025, 6, 852
DOI: 10.1002/fft2.526

Chronic Exposure to Both Electronic and Conventional Cigarettes Alters Ileum and Colon Turnover, Immune Function, and Barrier Integrity in Mice

Madjid Djouina, Anaïs Ollivier, Christophe Waxin, Gwenola Kervoaze, Muriel Pichavant, Ségolène Caboche, Djamal Achour, Céline Grare, Delphine Beury, David Hot, Sébastien Anthérieu, Jean-Marc Lo-Guidice, Laurent Dubuquoy, David Launay, Cécile Vignal, Philippe Gosset and Mathilde Body-Malapel

JoX, 2024, 14, 950
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Analysis of the intestinal flora in patients with primary liver cancer*

Chengcong Liu, Guoxin Sun, Huizhe Wang, Gaishuang Shang, Xiong Yan and Xiao Zou

Oncology and Translational Medicine, 2023, 9, 28
DOI: 10.1007/s10330-022-0575-5

Laxative Effect of Lactobacillus paracasei Glory LP16 on Loperamide‐Induced Constipation in Mice

Weiwei Ma, Lian Lian, Lidong Guo, Yanan Wu and Lili Huang

eFood, 2025, 6
DOI: 10.1002/efd2.70068

Mechanism analysis of the differences in relieving constipation in a Balb/c constipation model mouse fed human milk probiotics or fermented milk

Baoyuan Zhao, Yajuan Wang, Shengyuan Wang, Guangqing Mu and Xiaomeng Wu

J Sci Food Agric, 2025, 105, 2594
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