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Influence of sequential blood purification therapy on myocardial injury and serum inflammatory cytokine levels in patients with organophosphate poisoning

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Discovery of (E)-2-(hydroxyimino)-N-(2 ((4methylpentyl)amino)ethyl)acetamide (KR-27425) as a non-pyridinium oxime reactivator of paraoxon-inhibited acetylcholinesterase

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Visible Light-Induced Pd-Catalyzed Alkyl-Heck Reaction of Oximes

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ACS Catal., 2021, 11, 3749
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Novel Dual-Mode Fluorescent Sensor for Detecting Chlorpyrifos and Cu(II)

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ACS Omega, 2025, 10, 29732
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Chemistry of Unsymmetrical C1-Substituted Oxabenzonorbornadienes

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Preparing a rat brain tissue samples for acetylcholinesterase activity measurement: The MM method

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Synthesis, characterization and evaluation of the simple benzaldoximes protective effect against lipid peroxidation

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Nanocellulose-Based Filters as Novel Barrier Systems for Chemical Warfare Agents

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Mechanistic Insights into Enhanced Reactivation of Organophosphate-Inhibited Enzymes by Methyl-Substituted 2-Pralidoxime Analogs

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Determination of K869, a Novel Oxime Reactivator of Acetylcholinesterase, in Rat Body Fluids and Tissues by Liquid-Chromatography Methods: Pharmacokinetic Study

Nela Vanova, Anna Hojna, Jaroslav Pejchal, David Herman, David Malinak, Eliska Prchalova, Kamil Musilek and Jana Zdarova Karasova

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FDA-Approved Oximes and Their Significance in Medicinal Chemistry

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Decarboxylases as hypothetical targets for actions of organophosphates: Molecular modeling for prediction of hidden and unexpected health threats

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Transitioning from Oxime to the Next Potential Organophosphorus Poisoning Therapy Using Enzymes

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Nanoparticles Loaded with Pralidoxime Wrapped in Tumor Cell Membranes: A New Strategy to Counteract the Central Nervous System Effects of Organophosphate Poisoning

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Off-target effects of the NADPH oxidase inhibitor mitoapocynin-encapsulated nanoparticles and free-drug oral treatment in a rat DFP model of neurotoxicity

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Halogenated monopyridinium oximes are less effective in reactivation of phosphylated cholinesterases than bisquaternary oximes

Zuzana Kohoutova, Eliska Prchalova, Rudolf Andrys, Karolina Knittelova, Marketa Formanova, Tereza Hofmanova, Miroslav Psotka, Kamil Musilek, Etienne Derat and David Malinak

Bioorganic Chemistry, 2024, 153, 107904
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Novel Medical Countermeasures for Nerve Agent and Pharmaceutical Based Agent Poisoning

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The lesion site of organophosphorus-induced central apnea and the effects of antidotes

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Sci Rep, 2023, 13
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N-substituted arylhydroxamic acids as acetylcholinesterase reactivators

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DESIGN, CHEMICAL SYNTHESIS, AND IN VITRO EVALUATION OF NOVEL UNCHARGED CHOLINESTERASE REACTIVATOR

Vendula Hepnarova, Martina Hrabinova, Jakub Opravil, Mojmir Vanek, Eva Mezeiova, Lukas Gorecki, Tomas Kucera, Daniel Jun, Ondrej Soukup, Lubica Muckova and Jan Korabecny

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The risk associated with organophosphorus nerve agents: from their discovery to their unavoidable threat, current medical countermeasures and perspectives

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Antibody-Targeted Liposomes for Enhanced Targeting of the Blood-Brain Barrier

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Pharm Res, 2022, 39, 1523
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Reagent‐Controlled Chemodivergent Approach to Thiazolines and Thiazines from α‐N‐Hydroxyimino Dithioesters

Subhasish Ray, Saurabh Singh, Ganesh Kumar, Gaurav Shukla and Maya Shankar Singh

Adv Synth Catal, 2022, 364, 3204
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Warfare Nerve Agents and Paraoxonase-1 as a Potential Prophylactic Therapy against Intoxication

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Ellman’s reagent for specific turn-on chromogenic detection and differentiation of nerve agents: A platform for enzyme-free approach

Lav Kumar Yadav, G. Raviraju, Yogesh Kumar, Vinod K. Lodhi, Shyam S. Sarkar and Vinod Kumar

Microchemical Journal, 2025, 212, 113298
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Succinate prodrugs in combination with atropine and pralidoxime protect cerebral mitochondrial function in a rodent model of acute organophosphate poisoning

Sarah Piel, Joanna I. Janowska, J. Laurenson Ward, Meagan J. McManus, Joshua S. Jose, Jonathan Starr, Malkah Sheldon, Carly L. Clayman, Eskil Elmér, Magnus J. Hansson, David H. Jang, Michael Karlsson, Johannes K. Ehinger and Todd J. Kilbaugh

Sci Rep, 2022, 12
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A cocaine hydrolase engineered from human butyrylcholinesterase as a medical countermeasure for aldicarb poisoning

Johnathan E. LeSaint, Nellore Bhanu Chandar, Annet Kyomuhangi, Huimei Wei, Fang Zheng and Chang-Guo Zhan

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Toxicity assessment of VX in zebrafish: multi-organ toxicity evaluation and tissue distribution visualization using DESI-MSI

Manzhu Cao, Yi Zhang, Mengxuan Dong, Dongxin Liu, Yuxin Lin, Qian Jin, Liqin Li, Xingxing Zong and Chen Wang

Arch Toxicol, 2025
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Review about Structure and Evaluation of Reactivators of Acetylcholinesterase Inhibited with Neurotoxic Organophosphorus Compounds

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CMC, 2021, 28, 1422
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