One sample fits all: a microfluidic-assisted methodology for label-free isolation of CTCs with downstream methylation analysis of cfDNA in lung cancer

Ângela Carvalho, Catarina Guimarães-Teixeira, Vera Constâncio, Mariana Fernandes, Catarina Macedo-Silva, Rui Henrique, Fernando Jorge Monteiro and Carmen Jerónimo

Biomater. Sci., 2022, 10, 3296
DOI: 10.1039/D2BM00044J

Antibodies, repertoires and microdevices in antibody discovery and characterization

Luca Johannes Schlotheuber, Ines Lüchtefeld and Klaus Eyer

Lab Chip, 2024, 24, 1207
DOI: 10.1039/D3LC00887H

OPENchip: an on-chip in situ molecular profiling platform for gene expression analysis and oncogenic mutation detection in single circulating tumour cells

Amos C. Lee, Jessica Svedlund, Evangelia Darai, Yongju Lee, Daewon Lee, Han-Byoel Lee, Sung-Min Kim, Okju Kim, Hyung Jong Bae, Ahyoun Choi, Sumin Lee, Yunjin Jeong, Seo Woo Song, Yeongjae Choi, Huiran Yeom, Caleb S. Lee, Wonshik Han, Dong Soon Lee, Jin-Young Jang, Narayanan Madaboosi, Mats Nilsson and Sunghoon Kwon

Lab Chip, 2020, 20, 912
DOI: 10.1039/C9LC01248F

Droplet microfluidics for CTC-based liquid biopsy: a review

Lin Jiang, Hang Yang, Weiqi Cheng, Zhonghua Ni and Nan Xiang

Analyst, 2023, 148, 203
DOI: 10.1039/D2AN01747D

Single-Circulating Tumor Cell Whole Genome Amplification to Unravel Cancer Heterogeneity and Actionable Biomarkers

Tanzila Khan, Therese M. Becker, Joseph W. Po, Wei Chua and Yafeng Ma

IJMS, 2022, 23, 8386
DOI: 10.3390/ijms23158386

Development of Microfluidic System Enabling High-Throughput Characterization of Multiple Biophysical Parameters of Single Cells

Ke Wang, Yan Liu, Deyong Chen, Junbo Wang and Jian Chen

IEEE Trans. Electron Devices, 2022, 69, 2015
DOI: 10.1109/TED.2022.3152474

Microfluidic-SERS Technologies for CTC: A Perspective on Clinical Translation

Amin Hassanzadeh-Barforoushi, Anastasiia Tukova, Audrey Nadalini, David W. Inglis, Simon Chang-Hao Tsao and Yuling Wang

ACS Appl. Mater. Interfaces, 2024
DOI: 10.1021/acsami.4c01158

Interfacing microfluidics with information-rich detection systems for cells, bioparticles, and molecules

Jared P. Smithers and Mark A. Hayes

Anal Bioanal Chem, 2022, 414, 4575
DOI: 10.1007/s00216-022-04043-1

Cell Separations and Sorting

Malgorzata A. Witek, Ian M. Freed and Steven A. Soper

Anal. Chem., 2020, 92, 105
DOI: 10.1021/acs.analchem.9b05357

Advanced techniques for gene heterogeneity research: Single‐cell sequencing and on‐chip gene analysis systems

Zaizai Dong, Yu Wang, Dedong Yin, Xinxin Hang, Lei Pu, Jianfu Zhang, Jia Geng and Lingqian Chang

VIEW, 2022, 3
DOI: 10.1002/VIW.20210011

Methods and platforms for analysis of nucleic acids from single-cell based on microfluidics

Luyao Liu, Xiaobin Dong, Yunping Tu, Guijun Miao, Zhongping Zhang, Lulu Zhang, Zewen Wei, Duli Yu and Xianbo Qiu

Microfluid Nanofluid, 2021, 25
DOI: 10.1007/s10404-021-02485-0

Microstructure-based techniques for single-cell manipulation and analysis

Long Pang, Jing Ding, Xi-Xian Liu, Haoyue Yuan, Yuxin Ge, Jianglin Fan and Shih-Kang Fan

TrAC Trends in Analytical Chemistry, 2020, 129, 115940
DOI: 10.1016/j.trac.2020.115940

Smart Droplet Microfluidic System for Single-Cell Selective Lysis and Real-Time Sorting Based on Microinjection and Image Recognition

Zhihang Yu, Jing Jin, Siyuan Chen, Lingling Shui, Huaying Chen, Liuyong Shi and Yonggang Zhu

Anal. Chem., 2023, 95, 12875
DOI: 10.1021/acs.analchem.3c02182

Single-Cell Digital Microfluidic Mass Spectrometry Platform for Efficient and Multiplex Genotyping of Circulating Tumor Cells

Qingyu Ruan, Jian Yang, Fenxiang Zou, Xiaofeng Chen, Qianqian Zhang, Kaifeng Zhao, Xiaoye Lin, Xi Zeng, Xiyuan Yu, Lingling Wu, Shuichao Lin, Zhi Zhu and Chaoyong Yang

Anal. Chem., 2022, 94, 1108
DOI: 10.1021/acs.analchem.1c04194

Recent advances and application of whole genome amplification in molecular diagnosis and medicine

Xiaoyu Wang, Yapeng Liu, Hongna Liu, Wenjing Pan, Jie Ren, Xiangming Zheng, Yimin Tan, Zhu Chen, Yan Deng, Nongyue He, Hui Chen and Song Li

MedComm, 2022, 3
DOI: 10.1002/mco2.116

Precise monodisperse droplet generation by pressure-driven microfluidic flows

Wen Zeng, Shun Yang, Yichao Liu, Tianhang Yang, Zhizhong Tong, Xiaobiao Shan and Hai Fu

Chemical Engineering Science, 2022, 248, 117206
DOI: 10.1016/j.ces.2021.117206

Comparison of Multiple Displacement Amplification (MDA) and Multiple Annealing and Looping-Based Amplification Cycles (MALBAC) in Limited DNA Sequencing Based on Tube and Droplet

Xiaoxiang Zhou, Ying Xu, Libo Zhu, Zhen Su, Xiaoming Han, Zhen Zhang, Yan Huang and Quanjun Liu

Micromachines, 2020, 11, 645
DOI: 10.3390/mi11070645

Microfluidic single-cell analysis—Toward integration and total on-chip analysis

Cheuk Wang Fung, Shek Nga Chan and Angela Ruohao Wu

Biomicrofluidics, 2020, 14
DOI: 10.1063/1.5131795

A Microfluidic Chip for Efficient Circulating Tumor Cells Enrichment, Screening, and Single‐Cell RNA Sequencing

Fanghao Shi, Fei Jia, Zewen Wei, Yan Ma, Zhiguo Fang, Weikai Zhang and Zhiyuan Hu

Proteomics, 2021, 21
DOI: 10.1002/pmic.202000060

Separation and Analysis of Rare Tumor Cells in Various Body Fluids Based on Microfluidic Technology for Clinical Applications

Chang Xu, Dexin Du, Zhaojun Han, Haibin Si, Wei Li, Lu Li and Bo Tang

Anal. Chem., 2025, 97, 7567
DOI: 10.1021/acs.analchem.4c06925

Quantitative study of droplet generation by pressure-driven microfluidic flows in a flow-focusing microdroplet generator

Wen Zeng, Bohang Wang, Honglong Chang and Pavel Neužil

Physics of Fluids, 2024, 36
DOI: 10.1063/5.0191064

Microfluidic Compartmentalization Platforms for Single Cell Analysis

Xuhao Luo, Jui-Yi Chen, Marzieh Ataei and Abraham Lee

Biosensors, 2022, 12, 58
DOI: 10.3390/bios12020058