Ligand-controlled switch in diastereoselectivities: catalytic asymmetric construction of spirocyclic pyrrolidine-azetidine/oxe(thie)tane derivatives

Hua Deng, Renmeng Jia, Wu-Lin Yang, Xingxin Yu and Wei-Ping Deng

Chem. Commun., 2019, 55, 7346
DOI: 10.1039/C9CC03589C

Synthesis of pyrrolidin-2-ylidenes and pyrrol-2-ylidenes via 1,3-dipolar cycloaddition of H-bond-assisted azomethine ylides to nitrostyrenes

Issa Yavari, Ramin Mohsenzadeh, Parisa Ravaghi and Maryam Safaei

Org. Biomol. Chem., 2023, 21, 5265
DOI: 10.1039/D3OB00725A

Phosphine-catalysed asymmetric dearomative formal [4+2] cycloadditions of 3-benzofuranyl vinyl ketones

Ben-Xian Xiao, Bo Jiang, Xue Song, Wei Du and Ying-Chun Chen

Chem. Commun., 2019, 55, 3097
DOI: 10.1039/C9CC00386J

Phosphine-catalyzed dearomative (3 + 2) annulation of 2-nitrobenzofurans and nitrobenzothiophenes with allenoates

Jian-Qiang Zhao, Lei Yang, Yong You, Zhen-Hua Wang, Ke-Xin Xie, Xiao-Mei Zhang, Xiao-Ying Xu and Wei-Cheng Yuan

Org. Biomol. Chem., 2019, 17, 5294
DOI: 10.1039/C9OB00775J

Copper-catalyzed [3 + 2]-cycloaddition of α-halonitroalkenes with azomethine ylides: facile synthesis of multisubstituted pyrrolidines and pyrroles

Vladimir A. Motornov, Andrey A. Tabolin, Yulia V. Nelyubina, Valentine G. Nenajdenko and Sema L. Ioffe

Org. Biomol. Chem., 2021, 19, 3413
DOI: 10.1039/D1OB00146A

Enantioselective dearomative [3+2] cycloaddition of 2-nitrobenzofurans with aldehyde-derived Morita–Baylis–Hillman carbonates

Xin-He Yang, Jian-Ping Li, Dong-Chao Wang, Ming-Sheng Xie, Gui-Rong Qu and Hai-Ming Guo

Chem. Commun., 2019, 55, 9144
DOI: 10.1039/C9CC04542B

Higher-order [10 + 2] cycloaddition of 2-alkylidene-1-indanones enables the dearomatization of 3-nitroindoles: access to polycyclic cyclopenta[b]indoline derivatives

Jian-Qiang Zhao, Shun Zhou, Hui-Ling Qian, Zhen-Hua Wang, Yan-Ping Zhang, Yong You and Wei-Cheng Yuan

Org. Chem. Front., 2022, 9, 3322
DOI: 10.1039/D2QO00289B

Asymmetric decarboxylative [3 + 2] cycloaddition for the diastereo- and enantioselective synthesis of spiro[2.4]heptanes via cyclopropanation

Can Gao, Ting Zhang, Xiaoxun Li, Jing-De Wu and Jitian Liu

Org. Chem. Front., 2022, 9, 2121
DOI: 10.1039/D2QO00124A

Catalytic asymmetric synthesis of diazabicyclo[3.1.0]hexanes by 1,3-dipolar cycloaddition of azomethine ylides with azirines

Alba Molina, Sergio Díaz-Tendero, Javier Adrio and Juan C. Carretero

Chem. Commun., 2020, 56, 5050
DOI: 10.1039/D0CC01061H

Catalytic asymmetric dearomative [4 + 2] annulation of 2-nitrobenzofurans and 5H-thiazol-4-ones: stereoselective construction of dihydrobenzofuran-bridged polycyclic skeletons

Jian-Qiang Zhao, Shun Zhou, Zhen-Hua Wang, Yong You, Shuang Chen, Xiong-Li Liu, Ming-Qiang Zhou and Wei-Cheng Yuan

Org. Chem. Front., 2021, 8, 6330
DOI: 10.1039/D1QO01061A

Stereodivergent synthesis of enantioenriched azepino[3,4,5-cd]-indoles via cooperative Cu/Ir-catalyzed asymmetric allylic alkylation and intramolecular Friedel–Crafts reaction

Lu Xiao, Bo Li, Fan Xiao, Cong Fu, Liang Wei, Yanfeng Dang, Xiu-Qin Dong and Chun-Jiang Wang

Chem. Sci., 2022, 13, 4801
DOI: 10.1039/D1SC07271D

Asymmetric dearomatization of 2-nitrobenzofurans by organocatalyzed one-step Michael addition to access 3,3′-disubstituted oxindoles

Zhen-Zhen Ge, Lei Yang, Yong You, Zhen-Hua Wang, Ke-Xin Xie, Ming-Qiang Zhou, Jian-Qiang Zhao and Wei-Cheng Yuan

Chem. Commun., 2020, 56, 2586
DOI: 10.1039/C9CC09939E

Dearomative 1,6-addition of P(O)–H to in situ formed p-QM-like ion pairs from 2-benzofuryl-ols to C3-phosphinoyl hydrobenzofurans

Long Chen, Yun-Xiang Zou, Shi-Lu Zheng, Xiao-Yan Liu, Hong-Li Yang, Jing Zhang, Yao Zeng, Li Duan, Zhong Wen and Hai-Liang Ni

Org. Chem. Front., 2021, 8, 1756
DOI: 10.1039/D1QO00076D

Silver‐Catalyzed Asymmetric Dearomatization of Electron‐Deficient Heteroarenes via Interrupted Barton–Zard Reaction

Qian Wan, Jia‐Hao Xie, Chao Zheng, Yao‐Feng Yuan and Shu‐Li You

Angew Chem Int Ed, 2021, 60, 19730
DOI: 10.1002/anie.202107767

Pd-Catalyzed Intramolecular Dearomative [4 + 2] Cycloaddition of Naphthalenes with Arylalkynes

Jin-Bo Lu, Xiao-Qiu Xu, Zi-Sheng Ruan, Kai Liu, Ren-Xiao Liang and Yi-Xia Jia

Org. Lett., 2023, 25, 8139
DOI: 10.1021/acs.orglett.3c03240

Ag-Catalyzed Asymmetric Interrupted Barton–Zard Reaction Enabling the Enantioselective Dearomatization of 2- and 3-Nitroindoles

Wei-Cheng Yuan, Xin-Meng Chen, Jian-Qiang Zhao, Yan-Ping Zhang, Zhen-Hua Wang and Yong You

Org. Lett., 2022, 24, 826
DOI: 10.1021/acs.orglett.1c04036

Organocatalyzed asymmetric dearomative 1,3‐dipolar cycloaddition of 2‐nitrobenzofurans and N‐2,2,2‐trifluoroethylisatin ketimines

Xiao‐Jian Zhou, Jian‐Qiang Zhao, Yue‐Qin Lai, Yong You, Zhen‐Hua Wang and Wei‐Cheng Yuan

Chirality, 2022, 34, 1019
DOI: 10.1002/chir.23455

Organocatalytic Asymmetric Dearomatization of 3-Nitroindoles and 3-Nitrobenzothiophenes via Thiol-Triggered Diastereo- and Enantioselective Double Michael Addition Reaction

Xin-Meng Chen, Chuan-Wen Lei, Deng-Feng Yue, Jian-Qiang Zhao, Zhen-Hua Wang, Xiao-Mei Zhang, Xiao-Ying Xu and Wei-Cheng Yuan

Org. Lett., 2019, 21, 5452
DOI: 10.1021/acs.orglett.9b01688

Dinuclear Zinc Catalyzed Enantioselective Dearomatization [3+2] Annulation of 2‐Nitrobenzofurans and 2‐Nitrobenzothiophenes

Peng Zhou, Yang Yi, Yuan‐Zhao Hua, Shi‐Kun Jia and Min‐Can Wang

Chemistry A European J, 2022, 28
DOI: 10.1002/chem.202103688

Diastereoselective Synthesis of Dihydrobenzofuran-Fused Spiroindolizidines via Double-Dearomative [3 + 2] Cycloadditions

Xiao-Long He, You-Wu Wen, Hechen Li, Shan Qian, Mengyang He, Qiao Song and Zhouyu Wang

J. Org. Chem., 2023, 88, 493
DOI: 10.1021/acs.joc.2c02495

Organocatalyzed Asymmetric Dearomative Aza-Michael/Michael Addition Cascade of 2-Nitrobenzofurans and 2-Nitrobenzothiophenes with 2-Aminochalcones

Xiao-Jian Zhou, Jian-Qiang Zhao, Xin-Meng Chen, Jun-Rui Zhuo, Yan-Ping Zhang, Yong-Zheng Chen, Xiao-Mei Zhang, Xiao-Ying Xu and Wei-Cheng Yuan

J. Org. Chem., 2019, 84, 4381
DOI: 10.1021/acs.joc.9b00401

New reactions of 3,4‐dihydro‐6,7‐dimethoxyisoquinoline ylide with nitrile derivatives

Márk Molnár, Krisztina E. Treuerne Balázs, Zoltán Madarász and Miklós Nyerges

Journal of Heterocyclic Chem, 2022, 59, 1635
DOI: 10.1002/jhet.4496

Stereodivergent Synthesis of Chiral Hydrobenzofuranpyrrolidines by Catalytic Asymmetric Dearomative Cyclization and Controlled Epimerization

Wei Liu, Yeting Huang, Ziqiang Dai, Min Yu, Xuangan Liu, Weijun Yao and Xiaoyu Han

Adv Synth Catal, 2025, 367
DOI: 10.1002/adsc.202401194

Synthesis of Chiral Dispiro‐Indolinone‐Pyrrolidine‐Imidazolones Using (R) or (S)‐1‐(2,4‐Dimethoxyphenyl)Ethyl Amine

Vladislav S. Polyakov, Aleksandr A. Barashkin, Yuri K. Grishin, Elena A. Tarasenko and Elena K. Beloglazkina

ChemistrySelect, 2025, 10
DOI: 10.1002/slct.202501276

Synthesis of Dibenzofurans Derivatives via Benzannulation of 2‐Nitrobenzofurans and Alkylidene Malononitriles

Dongdong Cao, Dingben Chen, Gang Chen, Hanjie Mo, Zhijun Xia, Kai‐bin Li and Jianguo Yang

Asian J Org Chem, 2020, 9, 1610
DOI: 10.1002/ajoc.202000303

Chiral 1,2-Diaminocyclohexane-α-Amino Acid-Derived Amidphos/Ag(I)-Catalyzed Divergent Enantioselective 1,3-Dipolar Cycloaddition of Azomethine Ylides

Jie Luo, Youshi Liu, Haifei Wang, Chuliang Gong, Zhipeng Zhou and Qingxia Zhou

HETEROCYCLES, 2022, 104, 123
DOI: 10.3987/COM-21-14561

Base‐Catalysed (4+2)‐Annulation Between 2‐Nitrobenzofurans and N‐Alkoxyacrylamides: Synthesis of [3,2‐b]Benzofuropyridinones

Gunda Ananda Rao, Ramani Gurubrahamam and Kwunmin Chen

Eur J Org Chem, 2022, 2022
DOI: 10.1002/ejoc.202200657

Organocatalyzed Dearomative Cycloaddition of 2-Nitrobenzofurans and Isatin-Derived Morita–Baylis–Hillman Carbonates: Highly Stereoselective Construction of Cyclopenta[b]benzofuran Scaffolds

Jian-Qiang Zhao, Lei Yang, Xiao-Jian Zhou, Yong You, Zhen-Hua Wang, Ming-Qiang Zhou, Xiao-Mei Zhang, Xiao-Ying Xu and Wei-Cheng Yuan

Org. Lett., 2019, 21, 660
DOI: 10.1021/acs.orglett.8b03786

Catalytic Asymmetric Dearomative 1,3-Dipolar Cycloaddition of 2-Nitrobenzothiophenes and Isatin-Derived Azomethine Ylides

Jian-Qiang Zhao, Shun Zhou, Lei Yang, Hong-Yan Du, Yong You, Zhen-Hua Wang, Ming-Qiang Zhou and Wei-Cheng Yuan

Org. Lett., 2021, 23, 8600
DOI: 10.1021/acs.orglett.1c03318

Organocatalyzed Asymmetric Dearomative [3+2] Annulation of Electron‐Deficient 2‐Nitrobenzo Heteroarenes with 3‐Isothiocyanato Oxindoles

Pei‐Hao Dou, Yan Chen, Yong You, Zhen‐Hua Wang, Jian‐Qiang Zhao, Ming‐Qiang Zhou and Wei‐Cheng Yuan

Adv Synth Catal, 2021, 363, 4047
DOI: 10.1002/adsc.202100516

Base-mediated [4+2] annulation of electron-deficient nitrobenzoheterocycles and α,α-dicyanoalkenes in water: Facile access to structurally diverse functionalized dibenzoheterocyclic compounds

Jun-Rui Zhuo, Bao-Xue Quan, Jian-Qiang Zhao, Ming-Liang Zhang, Yong-Zheng Chen, Xiao-Mei Zhang and Wei-Cheng Yuan

Tetrahedron, 2020, 76, 131115
DOI: 10.1016/j.tet.2020.131115

Copper(I) Complexes Derived from 1,1′-Bis(diphenylphosphino)Ferrocene and Their Derivatives: Synthesis, Structure and Catalytic Studies for One-Pot Synthesis of Benzofuran

Suraj Peerappa Yadav, Deepika Sahil, Chandrakanta Dash, Sakshi Choudhary, Angshuman Roy Choudhury and Rohit Singh Chauhan

Catal Lett, 2024, 154, 2080
DOI: 10.1007/s10562-023-04457-1

Methods for the preparation of 2-nitrobenzofurans

Dmitry V. Osipov, Darya A. Rashchepkina, Pavel E. Krasnikov and Vitaly A. Osyanin

Chem Heterocycl Comp, 2023, 59, 183
DOI: 10.1007/s10593-023-03181-3

β-Substituted Alkenyl Heteroarenes as Dipolarophiles in the Cu(I)-Catalyzed Asymmetric 1,3-Dipolar Cycloaddition of Azomethine Ylides Empowered by a Dual Activation Strategy: Stereoselectivity and Mechanistic Insight

Xin Chang, Yuhong Yang, Chong Shen, Kun-Shan Xue, Zuo-Fei Wang, Hengjiang Cong, Hai-Yan Tao, Lung Wa Chung and Chun-Jiang Wang

J. Am. Chem. Soc., 2021, 143, 3519
DOI: 10.1021/jacs.0c12911

Dearomatization of Nitro(hetero)arenes through Annulation

Ning Wang, Jing Ren and Kaizhi Li

Eur J Org Chem, 2022, 2022
DOI: 10.1002/ejoc.202200039

Copper-Catalyzed Asymmetric Dearomative [3+2] Cycloaddition of Nitroheteroarenes with Azomethines

Yan Chen, Jian-Qiang Zhao, Yan-Ping Zhang, Ming-Qiang Zhou, Xiao-Mei Zhang and Wei-Cheng Yuan

Molecules, 2023, 28, 2765
DOI: 10.3390/molecules28062765

Transition Metal‐Catalyzed Enantioselective Synthesis of Chiral Five‐ and Six‐Membered Benzo O‐heterocycles

Lu Yang, Xiayu Liang, Yuyang Ding, Xinran Li, Xuefeng Li and Qingle Zeng

The Chemical Record, 2023, 23
DOI: 10.1002/tcr.202300173

Highly stereoselective construction of polycyclic benzofused tropane scaffolds and their latent bioactivities: bifunctional phosphonium salt-enabled cyclodearomatization process

Jian-Ping Tan, Xiaojie Li, Yuan Chen, Xianle Rong, Lixiang Zhu, Chunhui Jiang, Kai Xiao and Tianli Wang

Sci. China Chem., 2020, 63, 1091
DOI: 10.1007/s11426-020-9754-7

Metal-Free Diastereo- and Enantioselective Dearomative Formal [3 + 2] Cycloaddition of 2-Nitrobenzofurans and Isocyanoacetate Esters

Adrian Laviós, Amparo Sanz-Marco, Carlos Vila, M. Carmen Muñoz, José R. Pedro and Gonzalo Blay

Org. Lett., 2022, 24, 2149
DOI: 10.1021/acs.orglett.2c00427

Silver-Mediated [3 + 2] Cycloaddition of Azomethine Ylides with Trifluoroacetimidoyl Chlorides for the Synthesis of 5-(Trifluoromethyl)imidazoles

Hefei Yang, Shu-Ning Lu, Zhengkai Chen and Xiao-Feng Wu

J. Org. Chem., 2021, 86, 4361
DOI: 10.1021/acs.joc.1c00131

Enantioselective synthesis of chiral carbocyclic pyrimidine nucleosides via asymmetric cyclopropanation

Hai-Xia Wang, Wen-Peng Li, Chao Xia, Ming-Sheng Xie, Gui-Rong Qu and Hai-Ming Guo

Tetrahedron Letters, 2019, 60, 151183
DOI: 10.1016/j.tetlet.2019.151183

Catalytic Enantioselective Dearomatization/Rearomatization of 2-Nitroindoles to Access 3-Indolyl-3′-Aryl-/Alkyloxindoles: Application in the Formal Synthesis of Cyclotryptamine Alkaloids

Wei-Cheng Yuan, Xiao-Jian Zhou, Jian-Qiang Zhao, Yong-Zheng Chen, Yong You and Zhen-Hua Wang

Org. Lett., 2020, 22, 7088
DOI: 10.1021/acs.orglett.0c02350

Asymmetric Dearomative (3+2)-Cycloaddition Involving Nitro-Substituted Benzoheteroarenes under H-Bonding Catalysis

Maciej Saktura, Anna Skrzyńska, Sebastian Frankowski, Sylwia Wódka and Łukasz Albrecht

Molecules, 2021, 26, 4992
DOI: 10.3390/molecules26164992

Synthesis of Furo[3,2-b]quinolines and Furo[2,3-b:4,5-b′]diquinolines through [4 + 2] Cycloaddition of Aza-o-Quinone Methides and Furans

Lu Lei, Yi-Yun Yao, Li-Juan Jiang, Xiuqiang Lu, Cui Liang and Dong-Liang Mo

J. Org. Chem., 2020, 85, 3059
DOI: 10.1021/acs.joc.9b02953

Organocatalytic β,γ-Selective Activation of Deconjugated Butenolides Access to Chiral Tricyclic Chroman-butyrolactones

Yangqing Zheng, Weichao Jiang, Jingbo Tan, Juzhang Yan, Ruoting Zhan and Huicai Huang

J. Org. Chem., 2021, 86, 12821
DOI: 10.1021/acs.joc.1c01449

An Access to Highly Functionalized Dihydrobenzofuran Spirooxindole Scaffolds

Daqian Wang, Jing Sun, Ying Han, Qiu Sun and Chao-Guo Yan

Org. Lett., 2022, 24, 7790
DOI: 10.1021/acs.orglett.2c03123

Advances in the Chemical Transformations Involving Nitroalkenes Embedded in Heterocyclic Framework

Mukesh Kumar, Mritunjay, Sandeep Kumar, Ankush Gupta, Shubham Sharma, Pushpinder Singh and Akshay Kumar

Asian J Org Chem, 2025, 14
DOI: 10.1002/ajoc.202500140

Silver‐Catalyzed Asymmetric Dearomatization of Electron‐Deficient Heteroarenes via Interrupted Barton–Zard Reaction

Qian Wan, Jia‐Hao Xie, Chao Zheng, Yao‐Feng Yuan and Shu‐Li You

Angewandte Chemie, 2021, 133, 19882
DOI: 10.1002/ange.202107767

A Base‐Mediated Approach Towards Dihydrofuro[2,3‐b]Benzofurans from 2‐Nitrobenzofurans and 1,3‐Dicarbonyls

Gurdeep Singh, Rajat Pandey, Adarsh S. Kurup and Ramasamy Vijaya Anand

Chemistry An Asian Journal, 2021, 16, 1271
DOI: 10.1002/asia.202100184

Recent Progress of Electron‐Withdrawing‐Group‐Tethered Arenes Involved Asymmetric Nucleophilic Aromatic Functionalizations

Yan‐Li Li, Kai‐Kai Wang and Xiao‐Long He

Adv Synth Catal, 2022, 364, 3630
DOI: 10.1002/adsc.202200835

Copper(I)-catalyzed asymmetric 1,3-dipolar cycloaddition of 1,3-enynes and azomethine ylides

Bo-Ran Wang, Yan-Bo Li, Qi Zhang, Dingding Gao, Ping Tian, Qinghua Li and Liang Yin

Nat Commun, 2023, 14
DOI: 10.1038/s41467-023-40409-4

Cu-catalyzed endo-selective asymmetric 1,3-dipolar cycloaddition of azomethine ylides with ethenesulfonyl fluorides: Efficient access to chiral pyrrolidine-3-sulfonyl fluorides

Yi-Nan Li, Xin Chang, Qi Xiong, Xiu-Qin Dong and Chun-Jiang Wang

Chinese Chemical Letters, 2021, 32, 4029
DOI: 10.1016/j.cclet.2021.05.063

Unsymmetrical 1-oxazolinyl 1’,2-Bisphosphine ferrocene silyl ether: Preparation and lithiation mechanism

Di Xu, Li Dai, Ya-Qiong Zhi, Jun Zhang and Chu Xu

Journal of Organometallic Chemistry, 2019, 904, 120998
DOI: 10.1016/j.jorganchem.2019.120998

Enantioselective Synthesis of Fused Polycyclic Tropanes via Dearomative [3 + 2] Cycloaddition Reactions of 2-Nitrobenzofurans

Zhen Wang, Dong-Chao Wang, Ming-Sheng Xie, Gui-Rong Qu and Hai-Ming Guo

Org. Lett., 2020, 22, 164
DOI: 10.1021/acs.orglett.9b04108