Activity-based protein profiling: Recent advances in medicinal chemistry

Hui Deng, Qian Lei, Yangping Wu, Yang He and Weimin Li

European Journal of Medicinal Chemistry, 2020, 191, 112151
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Oxidant-Induced Bioconjugation for Protein Labeling in Live Cells

Yue Liu, Jiacong Liu, Xianfang Zhang, Cuiping Guo, Xiwen Xing, Zhi-Min Zhang, Ke Ding and Zhengqiu Li

ACS Chem. Biol., 2023, 18, 112
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2H-Azirine-Based Reagents for Chemoselective Bioconjugation at Carboxyl Residues Inside Live Cells

Nan Ma, Jun Hu, Zhi-Min Zhang, Wenyan Liu, Minhao Huang, Youlong Fan, Xingfeng Yin, Jigang Wang, Ke Ding, Wencai Ye and Zhengqiu Li

J. Am. Chem. Soc., 2020, 142, 6051
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Chemoproteomic-enabled phenotypic screening

Louis P. Conway, Weichao Li and Christopher G. Parker

Cell Chemical Biology, 2021, 28, 371
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Joint Screening and Identification of Potential Targets of Nitazoxanide by Affinity Chromatography and Label-Free Techniques

Menghan Zhu, Dongxia Qi, Dongliang Chen, Wenchong Ye, Xiaoyang Wang, Chunmei Wang, Wen Zhou, Bin Zhou, Juan Li and Keyu Zhang

CDT, 2024, 25, 819
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Design, Synthesis, and SAR of Covalent KIT and PDGFRA Inhibitors─Exploring Their Potential in Targeting GIST

Tom Schulz, Rajesh Gontla, Alina Teuber, Maria Beerbaum, Benjamin S. Fletcher, Thomas Mühlenberg, Helena Kaitsiotou, Julia Hardick, Kirujan Jeyakumar, Marina Keul, Matthias P. Müller, Sonja Sievers, Sebastian Bauer and Daniel Rauh

J. Med. Chem., 2025, 68, 3238
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A Tunable Hydrogel Platform Based on Platinum-Containing Polymeric Arsenicals

Alexandros Magiakos, Evelina Liarou, Spyridon Efstathiou, Andrea Dsouza, Chrystala Constantinidou, Marc Walker, Constantinos Methenitis and Paul Wilson

Chem. Mater., 2025, 37, 3733
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Novel Covalent Probe Selectively Targeting Glutathione Peroxidase 4 In Vivo: Potential Applications in Pancreatic Cancer Therapy

Zifeng Tang, Jie Li, Lijie Peng, Fang Xu, Yi Tan, Xiaoqiang He, Chengjun Zhu, Zhi-Min Zhang, Zhang Zhang, Pinghua Sun, Ke Ding and Zhengqiu Li

J. Med. Chem., 2024, 67, 1872
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Novel Electrophilic Warhead Targeting a Triple-Negative Breast Cancer Driver in Live Cells Revealed by “Inverse Drug Discovery”

Youlong Fan, Hongfei Si, Zhang Zhang, Liang Zhong, Hongyan Sun, Chengjun Zhu, Zhibin Yin, Huilin Li, Guanghui Tang, Shao Q. Yao, Pinghua Sun, Zhi-Min Zhang, Ke Ding and Zhengqiu Li

J. Med. Chem., 2021, 64, 15582
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Crenolanib‐Derived Probes Suitable for Cell‐ and Tissue‐Based Protein Profiling and Single‐Cell Imaging

Yu Chang, Dongsheng Zhu, Haijun Guo, Xingfeng Yin, Ke Ding and Zhengqiu Li

ChemBioChem, 2019, 20, 1783
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Two-photon fluorescent turn-on probes for highly efficient detection and profiling of thiols in live cells and tissues

Congzhen Shen, Duoteng Zhang, Fang Xu, Yang Yang, Yi Tan, Qian Zhao, Lin Li, Ke Ding and Zhengqiu Li

Biological Chemistry, 2022, 403, 445
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N-glycosylation of GSTO1 promotes cervical cancer migration and invasion through JAK/STAT3 pathway activation

Panpan Yu, Zouyu Zhao, Qianyu Sun, Bowen Diao, Chongfeng Sun, Yan Wang, Hui Qiao, Hong Li and Ping Yang

Funct Integr Genomics, 2025, 25
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Development of Benzenesulfonamide Derivatives as Potent Glutathione Transferase Omega-1 Inhibitors

Yiyue Xie, Padmaja Tummala, Aaron J. Oakley, Girdhar Singh Deora, Yuji Nakano, Melissa Rooke, Matthew E. Cuellar, Jessica M. Strasser, Jayme L. Dahlin, Michael A. Walters, Marco G. Casarotto, Philip G. Board and Jonathan B. Baell

J. Med. Chem., 2020, 63, 2894
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Modular Approaches to Synthesize Activity- and Affinity-Based Chemical Probes

Antonie J. van der Zouwen and Martin D. Witte

Front. Chem., 2021, 9
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Glucose-Induced Expression of DAPIT in Pancreatic β-Cells

Alberto Leguina-Ruzzi, Anežka Vodičková, Blanka Holendová, Vojtěch Pavluch, Jan Tauber, Hana Engstová, Andrea Dlasková and Petr Ježek

Biomolecules, 2020, 10, 1026
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Ynamide Electrophile for the Profiling of Ligandable Carboxyl Residues in Live Cells and the Development of New Covalent Inhibitors

Shengrong Li, Pengwei Zhang, Fang Xu, Shengcao Hu, Jiacong Liu, Yi Tan, Zhengchao Tu, Hongyan Sun, Zhi-Min Zhang, Qing-Yu He, Pinghua Sun, Ke Ding and Zhengqiu Li

J. Med. Chem., 2022, 65, 10408
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Applications of Activity‐Based Protein Profiling (ABPP) and Bioimaging in Drug Discovery

Jiaqian Xu, Xiaoqian Li, Ke Ding and Zhengqiu Li

Chemistry An Asian Journal, 2020, 15, 34
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Development and application of novel electrophilic warheads in target identification and drug discovery

Yue Liu, Shumin Lv, Lijie Peng, Chengliang Xie, Liqian Gao, Hongyan Sun, Ligen Lin, Ke Ding and Zhengqiu Li

Biochemical Pharmacology, 2021, 190, 114636
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Development of potent glutathione transferase Omega-1 inhibitors with applications in inflammation and cancer therapy

Yiyue Xie, Yuji Nakano, Padmaja Tummala, Aaron J. Oakley, Adi Suwandi, Matthew E. Cuellar, Jessica M. Strasser, Jayme L. Dahlin, Michael A. Walters, Marco G. Casarotto, Philip G. Board and Jonathan B. Baell

European Journal of Medicinal Chemistry, 2025, 299, 118072
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Appendage- and Scaffold-Diverse Electrophilic and Photoreactive Probes for Integrated Phenotypic Screening–Target Identification Campaigns via a Minimalist Bifunctional Isocyanide

Paul A. Jackson, Eleni Kisty, Vandan Pradhan, Christopher Swank, Luke Bohrer, Tammy L. Nolan, Eranthie Weerapana and David J. Lapinsky

ACS Omega, 2024, 9, 42557
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