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Recent development in biodegradable nanovehicle delivery system-assisted immunotherapy

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Biomater. Sci., 2019, 7, 4414
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Cancer immunotherapy boosted by layered double hydroxide nanoparticles

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Two-dimensional layered double hydroxide nanoadjuvant: recent progress and future direction

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Nanoscale, 2021, 13, 7533
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Amyloid-β/Tau burden and neuroinflammation dual-targeted nanomedicines synergistically restore memory and recognition of Alzheimer’s disease mice

Lingxiao Zhang, Shengjie Hou, Fatemeh Movahedi, Zijin Li, Li Li, Jing Hu, Yingbo Jia, Yaru Huang, Jie Zhu, Xiaoying Sun, Linghui Zeng, Ruitian Liu and Zhi Ping Xu

Nano Today, 2023, 49, 101788
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The application of nanotechnology in immune checkpoint blockade for cancer treatment

Huan Deng and Zhiping Zhang

Journal of Controlled Release, 2018, 290, 28
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Layered double hydroxides and their tailored hybrids/composites: Progressive trends for delivery of natural/synthetic-drug/cosmetic biomolecules

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Environmental Research, 2023, 238, 117171
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Two dimensional layered double hydroxides augment antigen loading and release

Ashtami Jayakumar, Christina Kuruvilla, Maggie Paulose, Lilly Schaffer, Paththini Kuttige S. Nonis, Hector A. Calderon, Oomman K. Varghese and Chandra Mohan

Biomaterials Advances, 2026, 184, 214817
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Modulating expression of inhibitory and stimulatory immune ‘checkpoints’ using nanoparticulate-assisted nucleic acid delivery

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Nanotechnology approaches in the current therapy of skin cancer

Livia Neves Borgheti-Cardoso, Juliana Santos Rosa Viegas, Ana Vitoria Pupo Silvestrini, Angelo Luis Caron, Fabiola Garcia Praça, Marcelo Kravicz and Maria Vitória Lopes Badra Bentley

Advanced Drug Delivery Reviews, 2020, 153, 109
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Nano drug delivery system reconstruct tumour vasculature for the tumour vascular normalisation

Qiangwei Liang, Liyue Zhou, Yifan Li, Jinxia Liu and Yanhua Liu

Journal of Drug Targeting, 2022, 30, 119
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Engineered NanoAlum from aluminum turns cold tumor hot for potentiating cancer metalloimmunotherapy

Yingbo Jia, Jing Hu, Chaojie Zhu, Zijing Li, Xinyu Yang, Ruitian Liu, Linghui Zeng and Lingxiao Zhang

Journal of Controlled Release, 2023, 354, 770
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Nanovaccine’s rapid induction of anti-tumor immunity significantly improves malignant cancer immunotherapy

Ling-xiao Zhang, Xia-mei Sun, Ying-bo Jia, Xiao-ge Liu, Mingdong Dong, Zhi Ping Xu and Rui-tian Liu

Nano Today, 2020, 35, 100923
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Two-dimensional nanomaterials for tumor microenvironment modulation and anticancer therapy

Miaomiao Wu, Xueming Niu, Run Zhang and Zhi Ping Xu

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Peptide nanovaccine in melanoma immunotherapy

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Efficient co-delivery of neo-epitopes using dispersion-stable layered double hydroxide nanoparticles for enhanced melanoma immunotherapy

Ling-xiao Zhang, Xi-xiu Xie, Dong-qun Liu, Zhi Ping Xu and Rui-tian Liu

Biomaterials, 2018, 174, 54
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The footprint of kynurenine pathway in every cancer: a new target for chemotherapy

Moein Ala

European Journal of Pharmacology, 2021, 896, 173921
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Covalent Functionalization of Layered Double Hydroxides to Generate Peptide-Based SARS-CoV-2 Nanovaccine

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Ultra-thin layered double hydroxide-mediated photothermal therapy combine with asynchronous blockade of PD-L1 and NR2F6 inhibit hepatocellular carcinoma

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Recent advances in LDH-based nanosystems for cancer therapy

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Development of Multifunctional Clay-Based Nanomedicine for Elimination of Primary Invasive Breast Cancer and Prevention of Its Lung Metastasis and Distant Inoculation

Ling-xiao Zhang, Xia-mei Sun, Zhi Ping Xu and Rui-tian Liu

ACS Appl. Mater. Interfaces, 2019, 11, 35566
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Nanoparticle‐Based Nanomedicines to Promote Cancer Immunotherapy: Recent Advances and Future Directions

Jianping Liu, Run Zhang and Zhi Ping Xu

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Layered double hydroxides‐based nanozymes for effective biomedical applications: A review and future perspectives

Jiawei Cui, Lu Zhang, Junyi Li, Yue Chen, Sheng Dai, Manfred F. Maitz, Ansha Zhao and Ping Yang

BMEMat, 2026, 4
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Nanoclays: Promising Materials for Vaccinology

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Biomimetic Nanomedicines Deliver Naringin for Enhanced Acute Liver Failure Therapy via Balanced Regulation of Hepatocyte Oxidative Stress and Kupffer Cell Inflammation

Jiahui Shao, Maoze Wang, Jinling Huang, Yu Wang, Jing Zhao, Ran Wang, Zhi Ping Xu, Jianping Jiang and Lingxiao Zhang

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Artificially tagging tumors with nano-aluminum adjuvant-tethered antigen mRNA recruits and activates antigen-specific cytotoxic T cells for enhanced cancer immunotherapy

Lingxiao Zhang, Jie Bai, Aining Shen, Jing Zhao, Zhenwei Su, Maoze Wang, Mingdong Dong and Zhi Ping Xu

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Interactions between Biological Cells and Layered Double Hydroxides: Towards Functional Materials

Claude Forano, Felipe Bruna, Christine Mousty and Vanessa Prevot

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Research progress in tumor targeted immunotherapy

Yuelin Fang, Aihua Yu, Lei Ye and Guangxi Zhai

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Engineering lattice defects in 2D nanomaterials for enhancing biomedical performances

Zhi Qi, Li Li and Zhi Ping Xu

Particuology, 2022, 64, 121
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Enhanced removal of natural organic matters by calcined Mg/Al layered double hydroxide nanocrystalline particles: Adsorption, reusability and mechanism studies

Liping Fang, Jingwei Hou, Cuihong Xu, Yaru Wang, Ji Li, Feng Xiao and Dongsheng Wang

Applied Surface Science, 2018, 442, 45
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Engineered nano-aluminum adjuvant for cancer immunotherapy: Progress, challenges and opportunities towards preclinical/clinical application

Chong Gao, Jianping Jiang, Jing Zhao, Zhi Ping Xu and Lingxiao Zhang

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Next-generation aluminum adjuvants: Immunomodulatory layered double hydroxide NanoAlum reengineered from first-line drugs

Zhenwei Su, Hamza Boucetta, Jiahui Shao, Jinling Huang, Ran Wang, Aining Shen, Wei He, Zhi Ping Xu and Lingxiao Zhang

Acta Pharmaceutica Sinica B, 2024, 14, 4665
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Interference of layered double hydroxide nanoparticles with pathways for biomedical applications

Guoxin Jing, Linnan Yang, Hong Wang, Jintong Niu, Youyuan Li and Shilong Wang

Advanced Drug Delivery Reviews, 2022, 188, 114451
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Efficient delivery of clay-based nanovaccines to the mouse spleen promotes potent anti-tumor immunity for both prevention and treatment of lymphoma

Ling-Xiao Zhang, Ying-Bo Jia, Ya-Ru Huang, Hui-Na Liu, Xia-Mei Sun, Ting Cai, Rui-Tian Liu and Zhi Ping Xu

Nano Res., 2021, 14, 1326
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NiFe-layered double hydroxide nanoparticle for co-delivery of DOX and siRNA to overcome multidrug resistance in MCF-7/ADR cells

Yan-Ni Bao, Xiu-Li Xie, Li-Li Lu, Wen-Hao Liu, Yu-Chen Ma, Yi-Jun Ke, Huan Ren, Li-Na Tan, Li-Fang Wu, Jue Song, Yong Jin and Xiao-Yan Liu

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STING-activating layered double hydroxide nano-adjuvants for enhanced cancer immunotherapy

Lirui Jia, Yang Qin, Xin Li, Hongzhuo Liu, Zhonggui He and Yongjun Wang

Biomaterials, 2025, 321, 123294
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Assessing the Adjuvant Effect of Layered Double Hydroxides (LDH) on BALB/c Mice

Dania O. Govea-Alonso, Mariano J. García-Soto, Emilio Sebastián Mendoza-Pérez, Susan Farfán-Castro, Diana Fuente, Omar González-Ortega and Sergio Rosales-Mendoza

Materials, 2023, 16, 5467
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Beyond Drug Delivery System: Immunomodulatory Layered Double Hydroxide Nanoadjuvants Take an Essential Step Forward in Cancer Immunotherapy

Chaojie Zhu, Jianping Jiang, Yingbo Jia, Zhi Ping Xu and Lingxiao Zhang

Acc. Mater. Res., 2023, 4, 758
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Nanoparticle-based delivery strategies of multifaceted immunomodulatory RNA for cancer immunotherapy

Yeon Jeong Yoo, Chang Hoon Lee, Sei Hyun Park and Yong Taik Lim

Journal of Controlled Release, 2022, 343, 564
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