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Divergent synthesis of nitrogen heterocyclesviaH2O-mediated hydride transfer reactions

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Tetrazole and acylsulfonamide bioisosteric replacements of the carboxylic acid in a dual MCL-1/BCL-xL inhibitor are tolerated

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Scaffold hopping from indoles to indazoles yields dual MCL-1/BCL-2 inhibitors from MCL-1 selective leads

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Copper-catalyzed construction of (Z)-benzo[cd]indoles: stereoselective intramolecular trans-addition and SN–Ar reaction

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Recent applications of covalent chemistries in protein–protein interaction inhibitors

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Discovery of N-sulfonylated aminosalicylic acids as dual MCL-1/BCL-xL inhibitors

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Synthetically important ring opening reactions by alkoxybenzenes and alkoxynaphthalenes

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Binding mode of Pyridoclax to myeloid cell leukemia-1 (Mcl-1) revealed by nuclear magnetic resonance spectroscopy, docking and molecular dynamics approaches

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Discovery and structure-activity relationship studies of N-substituted indole derivatives as novel Mcl-1 inhibitors

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Bioorganic & Medicinal Chemistry Letters, 2017, 27, 1943
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Synthesis of Tetrahydroquinoline‐Embedded Bridged Benzothiaoxazepine‐1,1‐dioxides

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Development of Mcl-1 inhibitors for cancer therapy

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European Journal of Medicinal Chemistry, 2021, 210, 113038
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Expanding the Cancer Arsenal with Targeted Therapies: Disarmament of the Antiapoptotic Bcl-2 Proteins by Small Molecules

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Recent progress in fragment-based drug discovery facilitated by NMR spectroscopy

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Desaturation via Redox-Neutral Hydrogen Transfer Process: Synthesis of 2-Allyl Anilines, Mechanism and Applications

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Synthesis and Elimination Pathways of 1-Methanesulfonyl-1,2-dihydroquinoline Sulfonamides

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MCL-1 inhibitors – where are we now (2019)?

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Helquats as Promoters of the Povarov Reaction: Synthesis of 1,2,3,4‐Tetrahydroquinoline Scaffolds Catalyzed by Helicene‐Viologen Hybrids

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Small-molecule Mcl-1 inhibitors: Emerging anti-tumor agents

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European Journal of Medicinal Chemistry, 2018, 146, 471
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The polypharmacy combination of the BCL-2 inhibitor venetoclax (VEN) and the FLT3 inhibitor gilteritinib (GIL) is more active in acute myeloid leukemia cells than novel polypharmacologic BCL-2/FLT3 VEN–GIL hybrid single-molecule inhibitors

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European Journal of Medicinal Chemistry, 2025, 285, 117190
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Discovery and Characterization of 2,5-Substituted Benzoic Acid Dual Inhibitors of the Anti-apoptotic Mcl-1 and Bfl-1 Proteins

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Recent Advances in the Development of Selective Mcl-1 Inhibitors for the Treatment of Cancer (2017-Present)

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Traceless Electrophilic Amination for the Synthesis of Unprotected Cyclic β-Amino Acids

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Diaryl Ether: A Privileged Scaffold for Drug and Agrochemical Discovery

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J. Agric. Food Chem., 2020, 68, 9839
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Structural Re‐engineering of the α‐Helix Mimetic JY‐1‐106 into Small Molecules: Disruption of the Mcl‐1–Bak‐BH3 Protein–Protein Interaction with 2,6‐Di‐Substituted Nicotinates

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Sulfonamide derivatives as potential anti-cancer agents and their SARs elucidation

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Palladium‐Catalyzed [4+2] and [5+2] Annulation for the Synthesis of Tetrahydroquinolines and 1,4‐Benzoxazepines

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1‐Sulfonylated 1,2,3,4‐tetrahydroquinoline‐6‐carboxylic acids as simple, readily‐accessible MCL‐1 inhibitors

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Augmenting the Anti‐Leukemic Activity of the BCL‐2 Inhibitor Venetoclax Through Its Transformation Into Polypharmacologic Dual BCL‐2/HDAC1 and Dual BCL‐2/HDAC6 Inhibitors

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Progress in the Chemistry of Tetrahydroquinolines

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Kröhnke pyridines: Rapid and facile access to Mcl-1 inhibitors

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Discovery of Mcl-1 inhibitors based on a thiazolidine-2,4-dione scaffold

Ellis Whiting, Mithun R. Raje, Jay Chauhan, Paul T. Wilder, Daniel Van Eker, Samuel J. Hughes, Nathan G. Bowen, Gregory E.A. Vickers, Ian C. Fenimore and Steven Fletcher

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Synthesis of methyl(ethyl) pyrazolo[4,3-b]pyridine-6-carboxylates and their conversion to tert-butyl 4,5,6,7-tetrahydropyrazolo-[4,3-b]pyridine-6-carboxylates

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Chem Heterocycl Comp, 2021, 57, 1137
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