Design of nanocarriers for nanoscale drug delivery to enhance cancer treatment using hybrid polymer and lipid building blocks

Rui Xue Zhang, Taksim Ahmed, Lily Yi Li, Jason Li, Azhar Z. Abbasi and Xiao Yu Wu

Nanoscale, 2017, 9, 1334
DOI: 10.1039/C6NR08486A

Self-assembled core–polyethylene glycol–lipid shell nanoparticles demonstrate high stability in shear flow

Zhiqiang Shen, Huilin Ye, Martin Kröger and Ying Li

Phys. Chem. Chem. Phys., 2017, 19, 13294
DOI: 10.1039/C7CP01530E

Redox-sensitive dendrimersomes assembled from amphiphilic Janus dendrimers for siRNA delivery

Xiao-Jiao Du, Ze-Yu Wang and Yu-Cai Wang

Biomater. Sci., 2018, 6, 2122
DOI: 10.1039/C8BM00491A

Lipid–polymer hybrid nanoparticles for synergistic drug delivery to overcome cancer drug resistance

Shao-Qi Zeng, Yi-Zhen Chen, Yong Chen and Hong Liu

New J. Chem., 2017, 41, 1518
DOI: 10.1039/C6NJ02819E

LipoParticles: a lipid membrane coating onto polymer particles to enhance the internalization in osteoblast cells

Florian Vanneste, Allison Faure, Mathieu Varache, Mario Menendez-Miranda, Virginie Dyon-Tafani, Sébastien Dussurgey, Elisabeth Errazuriz-Cerda, Veronica La Padula, Pierre Alcouffe, Marie Carrière, Ruxandra Gref, Frédéric Laurent, Jérôme Josse and Catherine Ladavière

Nanoscale, 2023, 15, 18015
DOI: 10.1039/D3NR03267A

Engineering of redox-triggered polymeric lipid hybrid nanocarriers for selective drug delivery to cancer cells

B. Siva Lokesh, Suresh Ajmeera, Rajat Choudhary, Sanjaya Kumar Moharana, C. S. Purohit and V. Badireenath Konkimalla

J. Mater. Chem. B, 2025, 13, 1437
DOI: 10.1039/D4TB01236D

Membrane fluidity properties of lipid-coated polylactic acid nanoparticles

Yuanqing Gu and Björn M. Reinhard

Nanoscale, 2024, 16, 8533
DOI: 10.1039/D3NR06464F

Enhanced chemotherapeutic toxicity of cyclodextrin templated size-tunable rhodamine 6G nanoGUMBOS

Nimisha Bhattarai, Mi Chen, Rocío L. Pérez, Sudhir Ravula, Pratap Chhotaray, Suzana Hamdan, Karen McDonough, Suman Tiwari and Isiah M. Warner

J. Mater. Chem. B, 2018, 6, 5451
DOI: 10.1039/C8TB01115J

Impact of the biomolecular corona on the structure of PEGylated liposomes

Luca Digiacomo, Daniela Pozzi, Heinz Amenitsch and Giulio Caracciolo

Biomater. Sci., 2017, 5, 1884
DOI: 10.1039/C7BM00387K

Recent development in biodegradable nanovehicle delivery system-assisted immunotherapy

Zhenfu Wen, Fengyu Liu, Qing Chen, Yongqian Xu, Hongjuan Li and Shiguo Sun

Biomater. Sci., 2019, 7, 4414
DOI: 10.1039/C9BM00961B

Noninvasive photothermal cancer therapy nanoplatforms via integrating nanomaterials and functional polymers

Qingfu Ban, Ting Bai, Xiao Duan and Jie Kong

Biomater. Sci., 2017, 5, 190
DOI: 10.1039/C6BM00600K

Ultrafast charge-conversional nanocarrier for tumor-acidity-activated targeted drug elivery

Jing Liu, Shoaib Iqbal, Xiao-Jiao Du, Youyong Yuan, Xianzhu Yang, Hong-Jun Li and Jun Wang

Biomater. Sci., 2018, 6, 350
DOI: 10.1039/C7BM01025G

Insight into the interactions between nanoparticles and cells

Jingchao Li, Hongli Mao, Naoki Kawazoe and Guoping Chen

Biomater. Sci., 2017, 5, 173
DOI: 10.1039/C6BM00714G

Delivery process and effective design of vectors for cancer therapy

Fengyuan Gao, Bing Yu, Hailin Cong and Youqing Shen

J. Mater. Chem. B, 2022, 10, 6896
DOI: 10.1039/D2TB01326F

Hydrophilic nanoparticles packed in oral tablets can improve the plasma profile of short half-life hydrophobic drugs

Faisal Usman, Ibrahim Javed, Syed Zajif Hussain, Nazar Muhammad Ranjha and Irshad Hussain

RSC Adv., 2016, 6, 94896
DOI: 10.1039/C6RA11799F

Polymer stiffness governs template mediated self-assembly of liposome-like nanoparticles: simulation, theory and experiment

Zhiqiang Shen, David T. Loe, Alessandro Fisher, Martin Kröger, Jessica L. Rouge and Ying Li

Nanoscale, 2019, 11, 20179
DOI: 10.1039/C9NR07063J

A micellar cisplatin prodrug simultaneously eliminates both cancer cells and cancer stem cells in lung cancer

Yan-Hua Zhu, Chun-Yang Sun, Song Shen, Malik I. U. Khan, Yang-Yang Zhao, Yang Liu, Yu-Cai Wang and Jun Wang

Biomater. Sci., 2017, 5, 1612
DOI: 10.1039/C7BM00278E

Biomaterials for mRNA delivery

Mohammad Ariful Islam, Emma K. G. Reesor, Yingjie Xu, Harshal R. Zope, Bruce R. Zetter and Jinjun Shi

Biomater. Sci., 2015, 3, 1519
DOI: 10.1039/C5BM00198F

Monocyte cell membrane-derived nanoghosts for targeted cancer therapy

S. Krishnamurthy, M. K. Gnanasammandhan, C. Xie, K. Huang, M. Y. Cui and J. M. Chan

Nanoscale, 2016, 8, 6981
DOI: 10.1039/C5NR07588B

Polyactives: controlled and sustained bioactive release via hydrolytic degradation

N. D. Stebbins, J. J. Faig, W. Yu, R. Guliyev and K. E. Uhrich

Biomater. Sci., 2015, 3, 1171
DOI: 10.1039/C5BM00051C

Two-component reduction-sensitive lipid–polymer hybrid nanoparticles for triggered drug release and enhanced in vitro and in vivo anti-tumor efficacy

Liu-Jie Zhang, Bo Wu, Wei Zhou, Cai-Xia Wang, Qian Wang, Hui Yu, Ren-Xi Zhuo, Zhi-Lan Liu and Shi-Wen Huang

Biomater. Sci., 2017, 5, 98
DOI: 10.1039/C6BM00662K

Poly(glycoamidoamine) brush nanomaterials for systemic siRNA delivery in vivo

X. Luo, W. Wang, J. R. Dorkin, O. Veiseh, P. H. Chang, I. Abutbul-Ionita, D. Danino, R. Langer, D. G. Anderson and Y. Dong

Biomater. Sci., 2017, 5, 38
DOI: 10.1039/C6BM00683C

Therapeutic lipid-coated hybrid nanoparticles against bacterial infections

Lai Jiang, Hiang Wee Lee and Say Chye Joachim Loo

RSC Adv., 2020, 10, 8497
DOI: 10.1039/C9RA10921H

Amphiphilic copolymers change the nature of the ordered-to-disordered phase transition of lipid membranes from discontinuous to continuous

Afroditi Maria Zaki and Paola Carbone

Phys. Chem. Chem. Phys., 2019, 21, 13746
DOI: 10.1039/C9CP01293A

Fabrication of dendrimer-releasing lipidic nanoassembly for cancer drug delivery

Qihang Sun, Xinpeng Ma, Bo Zhang, Zhuxian Zhou, Erlei Jin, Youqing Shen, Edward A. Van Kirk, William J. Murdoch, Maciej Radosz and Weilin Sun

Biomater. Sci., 2016, 4, 958
DOI: 10.1039/C6BM00189K

Artificial and Naturally Derived Phospholipidic Bilayers as Smart Coatings of Solid-State Nanoparticles: Current Works and Perspectives in Cancer Therapy

Nicolò Maria Percivalle, Marco Carofiglio, Marzia Conte, Giada Rosso, Alessandro Bentivogli, Giulia Mesiano, Veronica Vighetto and Valentina Cauda

IJMS, 2022, 23, 15815
DOI: 10.3390/ijms232415815

Properties and Bioapplications of Amphiphilic Janus Dendrimers: A Review

Adina Căta, Ioana Maria Carmen Ienașcu, Mariana Nela Ştefănuț, Dan Roșu and Oana-Raluca Pop

Pharmaceutics, 2023, 15, 589
DOI: 10.3390/pharmaceutics15020589

Photoresponsive liposomes and LipoParticles by incorporating a photosensitizer agent in their lipid membrane

Théo Régagnon, Loic Bugnicourt-Moreira, Romain Ravaz, Pierre Idlas, Lilly Ramousset, Marie-Carole Kouassi, Theodossis Theodossiou, Kristian Berg, Mario Menendez-Miranda, Ruxandra Gref and Catherine Ladavière

Journal of Photochemistry and Photobiology A: Chemistry, 2023, 442, 114765
DOI: 10.1016/j.jphotochem.2023.114765

Comparative efficacy of amphotericin B-loaded chitosan nanoparticles and free amphotericin B drug against Leishmania tropica

Aamir Sohail, Rahat Ullah Khan, Momin Khan, Mehvish Khokhar, Safat Ullah, Arshad Ali, Hazrat Bilal, Saadullah Khattak, Mirwaise Khan and Baseer Ahmad

Bull Natl Res Cent, 2021, 45
DOI: 10.1186/s42269-021-00644-5

Lipid nanoparticle-based delivery of small interfering RNAs: New possibilities in the treatment of diverse diseases

Anis Askarizadeh, Fatemeh Vahdat-Lasemi, Sercan Karav, Prashant Kesharwani and Amirhossein Sahebkar

European Polymer Journal, 2025, 223, 113624
DOI: 10.1016/j.eurpolymj.2024.113624

Tailored Core‐Shell Nanocarrier for Therapeutic Drug Delivery via Visible Light Activation

Deric Andrade‐Alarcón, Víctor de la Asunción‐Nadal, Gastón A. Crespo and María Cuartero

Angewandte Chemie, 2026, 138
DOI: 10.1002/ange.202514317

An efficient controlled release strategy for hypertension therapy: Folate-mediated lipid nanoparticles for oral peptide delivery

Jinhua Li, Bin Chen, Ting Yu, Mengran Guo, Shengnan Zhao, Yi Zhang, Chaohui Jin, Xingchen Peng, Jun Zeng, Jian Yang and Xiangrong Song

Pharmacological Research, 2020, 157, 104796
DOI: 10.1016/j.phrs.2020.104796

An anti-inflammatory Glyburide-loaded nanoghost for atherosclerosis therapy: A red blood cell based bio-mimetic strategy

Zahra Karami, Mohammad Akrami, Jalil Mehrzad, Mehdi Esfandyari-Manesh, Ismaeil Haririan and Saeid Nateghi

Giant, 2023, 16, 100206
DOI: 10.1016/j.giant.2023.100206

Highlights on Cell-Penetrating Peptides and Polymer-Lipid Hybrid Nanoparticle: Overview and Therapeutic Applications for Targeted Anticancer Therapy

Pragathi Devanand Bangera, Divya Dhatri Kara, Katikala Tanvi, Vamshi Krishna Tippavajhala and Mahalaxmi Rathnanand

AAPS PharmSciTech, 2023, 24
DOI: 10.1208/s12249-023-02576-x

Lipid polymer hybrid nanocarriers: Insights into synthesis aspects, characterization, release mechanisms, surface functionalization and potential implications

Saurabh Shah, Paras Famta, Rajeev Singh Raghuvanshi, Shashi Bala Singh and Saurabh Srivastava

Colloid and Interface Science Communications, 2022, 46, 100570
DOI: 10.1016/j.colcom.2021.100570

α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma

Vanessa Sainz, Liane I.F. Moura, Carina Peres, Ana I. Matos, Ana S. Viana, Angela M. Wagner, Julia E. Vela Ramirez, Teresa S. Barata, Manuela Gaspar, Steve Brocchini, Mire Zloh, Nicholas A. Peppas, Ronit Satchi-Fainaro and Helena F. Florindo

Acta Biomaterialia, 2018, 76, 193
DOI: 10.1016/j.actbio.2018.06.029

A Review on Lipid- Polymer Hybrid Nanoparticles and Preparation with Recent Update

Subashini Raman, Syed Mahmood and Azizur Rahman

MSF, 2020, 981, 322
DOI: 10.4028/www.scientific.net/MSF.981.322

Fabrication of poly(sarcosine), poly (ethylene glycol), and poly (lactic-co-glycolic acid) polymeric nanoparticles for cancer drug delivery

Sankha Bhattacharya

Journal of Drug Delivery Science and Technology, 2021, 61, 102194
DOI: 10.1016/j.jddst.2020.102194

Interfacial Interactions of Nanoparticles and Molecular Nanostructures with Model Membrane Systems: Mechanisms, Methods, and Applications

Konstantin Balashev

Membranes, 2026, 16, 134
DOI: 10.3390/membranes16040134

Lipid polymer hybrid nanoparticles against lung cancer and their application as inhalable formulation

Seyedeh Negin Kassaee, Derek Richard, Godwin A. Ayoko and Nazrul Islam

Nanomedicine, 2024, 19, 2113
DOI: 10.1080/17435889.2024.2387530

Small Interfering RNA Carriers for Oncotherapy: A Preclinical Overview

Liliana Aranda-Lara, Alondra Escudero-Castellanos, Maydelid Trujillo-Nolasco, Enrique Morales-Avila, Blanca Ocampo-García, Rigoberto Oros-Pantoja, Virginia Sánchez-Monroy and Keila Isaac-Olivé

Pharmaceutics, 2025, 17, 1408
DOI: 10.3390/pharmaceutics17111408

Lipid–polymer hybrid nanocarrier-mediated cancer therapeutics: current status and future directions

Neeraj K. Garg, Nikunj Tandel, Rajesh S. Jadon, Rajeev K. Tyagi and Om P. Katare

Drug Discovery Today, 2018, 23, 1610
DOI: 10.1016/j.drudis.2018.05.033

Strategies for Preparing Different Types of Lipid Polymer Hybrid Nanoparticles in Targeted Tumor Therapy

Yong Zhuang, Yiye Zhao, Bingyue Wang, Qi Wang, Tiange Cai and Yu Cai

CPD, 2021, 27, 2274
DOI: 10.2174/1381612826666201120155558

Use of Nanoparticles in Medicine

Puneet Utreja, Shivani Verma, Mahfoozur Rahman and Lalit Kumar

CBE, 2020, 6, 7
DOI: 10.2174/2212711906666190724145101

Lipid-polymer hybrid nanoparticles as a targeted drug delivery system for melanoma treatment

Rodrigo Scopel, Manuel A. Falcão, Angélica Regina Cappellari, Fernanda B. Morrone, Silvia S. Guterres, Eduardo Cassel, Andrea M. Kasko and Rubem M. F. Vargas

International Journal of Polymeric Materials and Polymeric Biomaterials, 2022, 71, 127
DOI: 10.1080/00914037.2020.1809406

Lipid–polymer hybrid nanoparticle-mediated therapeutics delivery: advances and challenges

Rajendran J.C. Bose, Rramaswamy Ravikumar, Vengadeshprabu Karuppagounder, Devasier Bennet, Sabarinathan Rangasamy and Rajarajan A. Thandavarayan

Drug Discovery Today, 2017, 22, 1258
DOI: 10.1016/j.drudis.2017.05.015

In Situ Visualization of Dynamic Cellular Effects of Phospholipid Nanoparticles via High‐Speed Scanning Ion Conductance Microscopy

Kenry, Linhao Sun, Trifanny Yeo, Eshu Middha, Yuji Gao, Chwee Teck Lim, Shinji Watanabe and Bin Liu

Small, 2022, 18
DOI: 10.1002/smll.202203285

Intravitreal nanoparticles for retinal delivery

Xiaonan Huang and Ying Chau

Drug Discovery Today, 2019, 24, 1510
DOI: 10.1016/j.drudis.2019.05.005

Nucleation and growth in solution synthesis of nanostructures – From fundamentals to advanced applications

Ke-Jun Wu, Edmund C.M. Tse, Congxiao Shang and Zhengxiao Guo

Progress in Materials Science, 2022, 123, 100821
DOI: 10.1016/j.pmatsci.2021.100821

Advanced cancer targeting using aptamer functionalized nanocarriers for site-specific cargo delivery

Mahavir Narwade, Aazam Shaikh, Kavita R. Gajbhiye, Prashant Kesharwani and Virendra Gajbhiye

Biomater Res, 2023, 27
DOI: 10.1186/s40824-023-00365-y

Polymer-Lipid Hybrid Systems: Scope of Intravenous-To-Oral Switch in Cancer Chemotherapy

Md. Rizwanullah, Javed Ahmad, Saima Amin, Awanish Mishra, Mohammad Ruhal Ain and Mahfoozur Rahman

CNANOM, 2020, 10, 164
DOI: 10.2174/2468187309666190514083508

Synthesis of AB2 type hyperbranched polymer by CuAAC based 1,3-dipolar cycloaddition and its application in delivering curcumin to cancer cell cultures in-vitro

Komal Rao, Nimra Naz Siddiqui, Muhammad Abdullah, Salim Saifullah, Humera Jahan and Muhammad Raza Shah

Journal of Molecular Structure, 2023, 1290, 135878
DOI: 10.1016/j.molstruc.2023.135878

Organ-restricted delivery through stimuli-responsive nanocarriers for lung cancer therapy

Yirivinti Hayagreeva Dinakar, Archana Karole, Shabi Parvez, Vikas Jain and Shyam Lal Mudavath

Life Sciences, 2022, 310, 121133
DOI: 10.1016/j.lfs.2022.121133

Development of a bio-inspired phagocytic stable nanoghost with anti-inflammatory properties for management of inflammation in ulcerative colitis

Ahmed Mohsin Huran Al-Jawadri, Zahra Karami, Ismaeil Haririan, Mohammad Akrami and Mahdi Gholami

Journal of Drug Targeting, 2025, 33, 1215
DOI: 10.1080/1061186X.2025.2474644

Lipid based nanoparticles as a novel treatment modality for hepatocellular carcinoma: a comprehensive review on targeting and recent advances

Khaled Mahmoud, Shady Swidan, Mohamed El-Nabarawi and Mahmoud Teaima

J Nanobiotechnol, 2022, 20
DOI: 10.1186/s12951-022-01309-9

Lipid- and polymer-based formulations containing TNF-α inhibitors for the treatment of inflammatory bowel diseases

Silvia Voci, Agnese Gagliardi, Nicola Ambrosio, Antonella Zannetti and Donato Cosco

Drug Discovery Today, 2024, 29, 104090
DOI: 10.1016/j.drudis.2024.104090

Nanotherapy Targeting the Tumor Microenvironment

Bo-Shen Gong, Rui Wang, Hong-Xia Xu, Ming-Yong Miao and Zhen-Zhen Yao

CCDT, 2019, 19, 525
DOI: 10.2174/1568009619666181220103714

Advances in transdermal siRNAs delivery: A review of current research progress

Albert Sufianov, Aferin Beilerli, Valentin Kudriashov, Tatiana Ilyasova, Bu Wenjie and Ozal Beylerli

Non-coding RNA Research, 2023, 8, 392
DOI: 10.1016/j.ncrna.2023.05.008

Lipid nanoparticles for pulmonary fibrosis: A comprehensive review

Tushar Kanti Dhara, Sayak Khawas and Neelima Sharma

Pulmonary Pharmacology & Therapeutics, 2024, 87, 102319
DOI: 10.1016/j.pupt.2024.102319

Recent Development on Application of Nanomaterials‐Based Antibacterial Nanoparticles Against Oral Infections: A Comprehensive Review

Lixin Yue, Mulazim Hussain Asim, Alamgeer and Da Zhang

ChemistrySelect, 2025, 10
DOI: 10.1002/slct.202501546

Hybrid Vesicular Drug Delivery Systems for Cancer Therapeutics

Marzieh Mohammadi, Sahar Taghavi, Khalil Abnous, Seyed Mohammad Taghdisi, Mohammad Ramezani and Mona Alibolandi

Adv Funct Materials, 2018, 28
DOI: 10.1002/adfm.201802136

Development and characterization of lung surfactant-coated polymer nanoparticles for pulmonary drug delivery

Andrea Gonsalves, Parand Sorkhdini, Jasmine Bazinet, Moez Ghumman, Dinesh Dhamecha, Yang Zhou and Jyothi U. Menon

Biomaterials Advances, 2023, 150, 213430
DOI: 10.1016/j.bioadv.2023.213430

Lipid–Polymer Hybrid Nanosystems: A Rational Fusion for Advanced Therapeutic Delivery

Shweta Jain, Mudit Kumar, Pushpendra Kumar, Jyoti Verma, Jessica M. Rosenholm, Kuldeep K. Bansal and Ankur Vaidya

JFB, 2023, 14, 437
DOI: 10.3390/jfb14090437

A review on lipid-polymer hybrid nanocarriers in cancer

Dipanjan Karati, Swarupananda Mukherjee, Bhupendra Prajapati, Anannya Bose, Susanta Paul, Gehan M. Elossaily and Souvik Roy

Journal of Drug Delivery Science and Technology, 2024, 97, 105827
DOI: 10.1016/j.jddst.2024.105827

Recent advances in surface modification of micro- and nano-scale biomaterials with biological membranes and biomolecules

Manisha Sandupama Abesekara and Ying Chau

Front. Bioeng. Biotechnol., 2022, 10
DOI: 10.3389/fbioe.2022.972790

Matrix Metalloproteinase‐9‐Responsive Surface Charge‐Reversible Nanocarrier to Enhance Endocytosis as Efficient Targeted Delivery System for Cancer Diagnosis and Therapy

Qiu‐Ju Han, Xiao‐Tong Lan, Ying Wen, Chuan‐Zeng Zhang, Michael Cleary, Yasra Sayyed, Guangdong Huang, Xiaoling Tuo, Long Yi, Zhen Xi, Lu‐Yuan Li and Qiang‐Zhe Zhang

Adv Healthcare Materials, 2021, 10
DOI: 10.1002/adhm.202002143

Lipid polymer hybrid nanoparticles: a custom-tailored next-generation approach for cancer therapeutics

Kavita R. Gajbhiye, Rajesh Salve, Mahavir Narwade, Afsana Sheikh, Prashant Kesharwani and Virendra Gajbhiye

Mol Cancer, 2023, 22
DOI: 10.1186/s12943-023-01849-0

One-pot polyglycidol nanogels via liposome master templates for dual drug delivery

Jacob N. Lockhart, Dain B. Beezer, David M. Stevens, Benjamin R. Spears and Eva Harth

Journal of Controlled Release, 2016, 244, 366
DOI: 10.1016/j.jconrel.2016.07.013

A Facile Method to Coat Nanoparticles with Lipid Bilayer Membrane: Hybrid Silica Nanoparticles Disguised as Biomembrane Vesicles by Particle Penetration of Concentrated Lipid Layers

Ryosuke Mizuta, Fumihito Inoue, Yoshihiro Sasaki, Shin‐ichi Sawada and Kazunari Akiyoshi

Small, 2023, 19
DOI: 10.1002/smll.202206153

Polymer–Lipid Hybrid Nanosystems: An Emerging Advanced Therapeutic Tool

Nnamdi Ikemefuna Okafor, Nkeiruka N. Igbokwe, Ngozi Francisca Nnolum-Orji, Yahya E. Choonara and Srijoni Sengupta

Advances in Polymer Technology, 2025, 2025
DOI: 10.1155/adv/4707146

Advanced approaches in lung cancer therapy–Exploring the unique role of Multiwalled Carbon Nanotubes

Pushpendra Kumar Khangar and Vivek Daniel

Next Nanotechnology, 2025, 7, 100180
DOI: 10.1016/j.nxnano.2025.100180

Use of Chitosan-Coated Conductive Copper/Nanoparticle Polymer in Drug Delivery System by Encapsulation Method

Dilek Şenol Bahçeci, Aysel Aydın Kocaeren, Neslihan Demir and Büşra Dalgıç

Polym. Sci. Ser. B, 2024, 66, 649
DOI: 10.1134/S156009042560007X

Cancer‐Targeted Nanotheranostics: Recent Advances and Perspectives

Yufei Ma, Jie Huang, Saijie Song, Huabing Chen and Zhijun Zhang

Small, 2016, 12, 4936
DOI: 10.1002/smll.201600635

Core-shell lipid-polymer nanoparticles as a promising ocular drug delivery system to treat glaucoma

Yang Zhou, Aiping Fang, Fazhan Wang, Huili Li, Quansheng Jin, Lingjing Huang, Chunmei Fu, Jun Zeng, Zhaohui Jin and Xiangrong Song

Chinese Chemical Letters, 2020, 31, 494
DOI: 10.1016/j.cclet.2019.04.048

Ovarian carcinoma biological nanotherapy: Comparison of the advantages and drawbacks of lipid, polymeric, and hybrid nanoparticles for cisplatin delivery

Yingli Zhang, Ping Zhang and Tao Zhu

Biomedicine & Pharmacotherapy, 2019, 109, 475
DOI: 10.1016/j.biopha.2018.10.158

Salinomycin-Based Drug Delivery Systems: Overcoming the Hurdles in Cancer Therapy

Lucia Ruxandra Tefas, Cristina Barbălată, Cristian Tefas and Ioan Tomuță

Pharmaceutics, 2021, 13, 1120
DOI: 10.3390/pharmaceutics13081120

Albumin-based nanodevices for breast cancer diagnosis and therapy

Yue Wang, Haroon Iqbal, Uzair Ur-Rehman, Lina Zhai, Ziyin Yuan, Anam Razzaq, Man Lv, Huiying Wei, Xin Ning, Jun Xin and Run Xiao

Journal of Drug Delivery Science and Technology, 2023, 79, 104072
DOI: 10.1016/j.jddst.2022.104072

Stable Loading and Delivery of Melittin with Lipid-Coated Polymeric Nanoparticles for Effective Tumor Therapy with Negligible Systemic Toxicity

Ran Ye, Yuan Zheng, Yang Chen, Xiaohui Wei, Sanyuan Shi, Yuetan Chen, Wanxin Zhu, Anqi Wang, Liuxin Yang, Yuhong Xu and Jinliang Peng

ACS Appl. Mater. Interfaces, 2021, 13, 55902
DOI: 10.1021/acsami.1c17618

Exploring the therapeutic potential of lipid-based nanoparticles in the management of oral squamous cell carcinoma

Anis Ahmad Chaudhary, Mohammad Fareed, Salah-Ud-Din Khan, Lina M. Alneghery, Mohammed Aslam, Arockia Alex and Md. Rizwanullah

Exploration of Targeted Anti-tumor Therapy, 2024, 5, 1223
DOI: 10.37349/etat.2024.00272

Nanotechnology strategies for endometrium health: Are we on the right track?

Victoria Herrara, Dana Tarab-Ravski, Subhash C. Chauhan, Nikesh Narang, Mohammad Mirazul Islam, Dan Peer, Rajendra Prasad and Murali M. Yallapu

Bioactive Materials, 2025, 54, 423
DOI: 10.1016/j.bioactmat.2025.08.016

Preparation of Particulate Polymeric Therapeutics for Medical Applications

Jia Zhuang, Ronnie H. Fang and Liangfang Zhang

Small Methods, 2017, 1
DOI: 10.1002/smtd.201700147

Multi-component clobetasol-loaded monolithic lipid-polymer hybrid nanoparticles ameliorate imiquimod-induced psoriasis-like skin inflammation in Swiss albino mice

Sudeep Sudesh Pukale, Saurabh Sharma, Manu Dalela, Arihant kumar Singh, Sujata Mohanty, Anupama Mittal and Deepak Chitkara

Acta Biomaterialia, 2020, 115, 393
DOI: 10.1016/j.actbio.2020.08.020

Tunable morphology of lipid/chitosan particle assemblies

Loïc Bugnicourt, Soline Peers, Charline Dalverny and Catherine Ladavière

Journal of Colloid and Interface Science, 2019, 534, 105
DOI: 10.1016/j.jcis.2018.08.098

Polymer-hybrid nanoparticles: Current advances in biomedical applications

Daniel Crístian Ferreira Soares, Stephanie Calazans Domingues, Daniel Bragança Viana and Marli Luiza Tebaldi

Biomedicine & Pharmacotherapy, 2020, 131, 110695
DOI: 10.1016/j.biopha.2020.110695

Lipid-polymer hybrid nanoparticles: a cutting-edge frontier in breast cancer treatment strategies

Marwa Alawi, Ayah R Hilles, Mohit Kumar, Mohd Danish Ansari and Syed Mahmood

Nanomedicine, 2025, 20, 1775
DOI: 10.1080/17435889.2025.2523730

Lipogels for Encapsulation of Hydrophilic Proteins and Hydrophobic Small Molecules

Celia C. Homyak, Ann Fernandez, Mollie A. Touve, Bo Zhao, Francesca Anson, Jeanne A. Hardy, Richard W. Vachet, Nathan C. Gianneschi, Jennifer L. Ross and S. Thayumanavan

Biomacromolecules, 2018, 19, 132
DOI: 10.1021/acs.biomac.7b01300

Bio-nano interface: The impact of biological environment on nanomaterials and their delivery properties

Kaimin Cai, Andrew Z. Wang, Lichen Yin and Jianjun Cheng

Journal of Controlled Release, 2017, 263, 211
DOI: 10.1016/j.jconrel.2016.11.034

Nanomaterials in Targeted Immunotherapy for Chronic Spontaneous Urticaria: Focusing on Immune Cell Modulation and Precision Treatment

Wei Yao, Chaoxia Peng, Yufeng He, Guihong Yang, Dan Luo, Zhongsong Zhang, Long Chen and Xianqiong Huang

IJN, 2026, Volume 21, 1
DOI: 10.2147/IJN.S572074

Biologically modified nanoparticles as theranostic bionanomaterials

Jielai Yang, Xingcai Zhang, Chuang Liu, Zhen Wang, Lianfu Deng, Chan Feng, Wei Tao, Xiangyang Xu and Wenguo Cui

Progress in Materials Science, 2021, 118, 100768
DOI: 10.1016/j.pmatsci.2020.100768

Bispecific antibodies (anti-mPEG/anti-HER2) for active tumor targeting of docetaxel (DTX)-loaded mPEGylated nanocarriers to enhance the chemotherapeutic efficacy of HER2-overexpressing tumors

Chia-Yu Su, Michael Chen, Ling-Chun Chen, Yuan-Soon Ho, Hsiu-O Ho, Shyr-Yi Lin, Kuo-Hsiang Chuang and Ming-Thau Sheu

Drug Delivery, 2018, 25, 1066
DOI: 10.1080/10717544.2018.1466936

Selenium Nanoparticles (SeNPs) in Cancer Therapy: Revolutionizing Drug Delivery and Overcoming Treatment Challenges

Santhoshkumar Jayakodi, Tamilmaran Nagarajan and Dharmalingam Kirubakaran

Biomedical Materials & Devices, 2025
DOI: 10.1007/s44174-025-00586-w

Core-shell lipid-polymeric nanoparticles for enhanced oral bioavailability and antihypertensive efficacy of KY5 peptide

Jingmei Yuan, Mengran Guo, Shengnan Zhao, Jinhua Li, Xinchun Wang, Jian Yang, Zhaohui Jin and Xiangrong Song

Chinese Chemical Letters, 2023, 34, 107943
DOI: 10.1016/j.cclet.2022.107943

Nanomedicine-based cancer immunotherapy: a bibliometric analysis of research progress and prospects

Chaofan Chen, Pengfei Yuan and Zhiyun Zhang

Front. Immunol., 2024, 15
DOI: 10.3389/fimmu.2024.1446532

Impact of Nebulization on the Physicochemical Properties of Polymer–Lipid Hybrid Nanoparticles for Pulmonary Drug Delivery

Andrea Gonsalves and Jyothi U. Menon

IJMS, 2024, 25, 5028
DOI: 10.3390/ijms25095028

Development, Characterization, and Evaluation of Chi-Tn mAb-Functionalized DOTAP-PLGA Hybrid Nanoparticles Loaded with Docetaxel for Lung Cancer Therapy

Analía Castro, Álvaro Pittini, Nora Berois, Ricardo Faccio, Pablo Miranda, Álvaro W. Mombrú, Eduardo Osinaga and Helena Pardo

Pharmaceutics, 2025, 17, 164
DOI: 10.3390/pharmaceutics17020164

Tailored Core‐Shell Nanocarrier for Therapeutic Drug Delivery via Visible Light Activation

Deric Andrade‐Alarcón, Víctor de la Asunción‐Nadal, Gastón A. Crespo and María Cuartero

Angew Chem Int Ed, 2026, 65
DOI: 10.1002/anie.202514317

Preparation a core‐shell lipid/polymer nanoparticle containing Isotretinoin drug with pH sensitive property: A response surface methodology study

Tahereh Najafi Ghaghelestani, Nafiseh Farhadian and Nafiseh Binesh

J of Applied Polymer Sci, 2021, 138
DOI: 10.1002/app.50734

Lipid-based Nanoparticles: Strategy for Targeted Cancer Therapy

Ashish Singh Chauhan, Pallavi Chand and Tarun Parashar

BIOI, 2025, 6
DOI: 10.15212/bioi-2024-0107

YENİ NESİL LİPİT BAZLI İLAÇ TAŞIYICI SİSTEMLER: LİPİT NANOKAPSÜLLER

Hatice DEMİRTAŞ and Ceyda SENGEL-TURK

Ankara Universitesi Eczacilik Fakultesi Dergisi, 2022, 239
DOI: 10.33483/jfpau.1006409

Albumin based versatile multifunctional nanocarriers for cancer therapy: Fabrication, surface modification, multimodal therapeutics and imaging approaches

Ritu R. Kudarha and Krutika K. Sawant

Materials Science and Engineering: C, 2017, 81, 607
DOI: 10.1016/j.msec.2017.08.004

The possibility of angiogenesis inhibition in cutaneous melanoma by bevacizumab-loaded lipid-chitosan nanoparticles

Fereshteh Abdi, Elham Arkan, Mojtaba Eidizadeh, Elahe Valipour, Tahereh Naseriyeh, Younes Hossainy Gamizgy and Kamran Mansouri

Drug Deliv. and Transl. Res., 2023, 13, 568
DOI: 10.1007/s13346-022-01215-5

Niclosamide loaded biodegradable chitosan nanocargoes: an in vitro study for potential application in cancer therapy

Saba Naqvi, Shanid Mohiyuddin and P. Gopinath

R. Soc. open sci., 2017, 4, 170611
DOI: 10.1098/rsos.170611

Solid lipid nanoparticles in the diagnosis and treatment of prostate cancer: A comprehensive review of two decades of advancements

Pooja Tiwary, Krishil Oswal, Ryan Varghese, Harsh Anchan and Pardeep Gupta

Chemistry and Physics of Lipids, 2025, 270, 105510
DOI: 10.1016/j.chemphyslip.2025.105510

Recent updates in nanotechnological advances for wound healing: A narrative review

Hitesh Chopra, Yugal Kishore Mohanta, Saurov Mahanta, Tapan Kumar Mohanta, Inderbir Singh, Satya Kumar Avula, Sarada Prasanna Mallick, Ali A. Rabaan, Hajir AlSaihati, Ahmed Alsayyah, Mohammed Alissa, Hussain R. Alturaifi, Bader AlAlwan, Mohamed S. Attia, Sandip Chakraborty and Kuldeep Dhama

Nanotechnology Reviews, 2023, 12
DOI: 10.1515/ntrev-2023-0129

Recent advances of polymeric nanoplatforms for cancer treatment: smart delivery systems (SDS), nanotheranostics and multidrug resistance (MDR) inhibition

Urvashi Gupta, Dipak Maity and Virender K Sharma

Biomed. Mater., 2024, 19, 012003
DOI: 10.1088/1748-605X/ad0b23

EGF Receptor-Targeting Cancer Therapy Using CD47-Engineered Cell-Derived Nanoplatforms

Moon Jung Choi, Kang Chan Choi, Do Hyun Lee, Hwa Yeon Jeong, Seong Jae Kang, Min Woo Kim, In Ho Jeong, Young Myoung You, Jin Suk Lee, Yeon Kyung Lee, Chan Su Im and Yong Serk Park

NSA, 2022, Volume 15, 17
DOI: 10.2147/NSA.S352038

Converging paths: Microneedle-based dual intervention of IL-23/IL-17 axis and granuloma formation in rheumatoid nodules

Indhumathi Thirugnanasambandham, Veera Venkata Satyanarayana Reddy Karri, Sukriti Vishwas, Sachin Kumar Singh, Kamal Dua and Gowthamarajan Kuppusamy

Medical Hypotheses, 2024, 189, 111399
DOI: 10.1016/j.mehy.2024.111399

PEG-PLGA- hybrid nanoparticles loaded with etoricoxib – phospholipid complex for effective treatment of inflammation in rat model

Vivek Dave, Prarthana Srivastava, Kajal Tak and Swapnil Sharma

Journal of Microencapsulation, 2019, 36, 236
DOI: 10.1080/02652048.2019.1617362

Responsive Nanofibers with Embedded Hierarchical Lipid Self-Assemblies

Nguyen D. Tien, Anjani K. Maurya, Giuseppino Fortunato, Markus Rottmar, Robert Zboray, Rolf Erni, Alex Dommann, René M. Rossi, Antonia Neels and Amin Sadeghpour

Langmuir, 2020, 36, 11787
DOI: 10.1021/acs.langmuir.0c01487

Lipid/PAA-coated mesoporous silica nanoparticles for dual-pH-responsive codelivery of arsenic trioxide/paclitaxel against breast cancer cells

Bing-bing Zhang, Xiao-jie Chen, Xu-dong Fan, Jing-jing Zhu, Ying-hui Wei, Hang-sheng Zheng, Hong-yue Zheng, Bin-hui Wang, Ji-gang Piao and Fan-zhu Li

Acta Pharmacol Sin, 2021, 42, 832
DOI: 10.1038/s41401-021-00648-x

Paclitaxel and Erlotinib-co-loaded Solid Lipid Core Nanocapsules: Assessment of Physicochemical Characteristics and Cytotoxicity in Non-small Cell Lung Cancer

Biki Gupta, Bijay Kumar Poudel, Shobha Regmi, Shiva Pathak, Hima Bindu Ruttala, Milan Gautam, Gyeong Jin An, Jee-Heon Jeong, Han-Gon Choi, Chul Soon Yong and Jong Oh Kim

Pharm Res, 2018, 35
DOI: 10.1007/s11095-017-2337-6

TAT modified and lipid – PEI hybrid nanoparticles for co-delivery of docetaxel and pDNA

Shufang Dong, Xin Zhou and Jiying Yang

Biomedicine & Pharmacotherapy, 2016, 84, 954
DOI: 10.1016/j.biopha.2016.10.003

Lipid polymer hybrid nanoparticles as potent vehicles for drug delivery in cancer therapeutics

Shama Parveen, Pratishtha Gupta, Saurabh Kumar and Monisha Banerjee

Medicine in Drug Discovery, 2023, 20, 100165
DOI: 10.1016/j.medidd.2023.100165

Targeting Non-coding RNA for Glioblastoma Therapy: The Challenge of Overcomes the Blood-Brain Barrier

Rohit K. Sharma, Carlos Calderon and Pablo E. Vivas-Mejia

Front. Med. Technol., 2021, 3
DOI: 10.3389/fmedt.2021.678593

RETRACTED ARTICLE: Neoantigen vaccine nanoformulations based on Chemically synthesized minimal mRNA (CmRNA): small molecules, big impact

Saber Imani, Oya Tagit and Chantal Pichon

npj Vaccines, 2024, 9
DOI: 10.1038/s41541-024-00807-1

Novel lipid-polymer hybrid nanoparticles for siRNA delivery and IGF-1R gene silencing in breast cancer cells

Hannaneh monirinasab, Hamed Asadi, Kobra Rostamizadeh, Abdolreza Esmaeilzadeh, Malihe Khodaei and Mojtaba Fathi

Journal of Drug Delivery Science and Technology, 2018, 48, 96
DOI: 10.1016/j.jddst.2018.08.025

Nanoparticle-Based Therapies for Wound Biofilm Infection: Opportunities and Challenges

Min-Ho Kim

IEEE Trans.on Nanobioscience, 2016, 15, 294
DOI: 10.1109/TNB.2016.2527600

Metformin bicarbonate-mediated efficient RNAi for precise targeting of TP53 deficiency in colon and rectal cancers

Jiangsheng Xu, Yunhua Liu, Sheng Liu, Wenquan Ou, Alisa White, Samantha Stewart, Katherine H.R. Tkaczuk, Lee M. Ellis, Jun Wan, Xiongbin Lu and Xiaoming He

Nano Today, 2022, 43, 101406
DOI: 10.1016/j.nantod.2022.101406

How the Incorporation of Pluronic Block Copolymers Modulates the Response of Lipid Membranes to Mechanical Stress

Afroditi Maria Zaki and Paola Carbone

Langmuir, 2017, 33, 13284
DOI: 10.1021/acs.langmuir.7b02244

Triblock–Diblock Composite Nanoassemblies with Sequentially Addressable Host–Guest Properties for Hydrophobics and Hydrophilics

Jiaming Zhuang and S. Thayumanavan

ACS Macro Lett., 2020, 9, 1019
DOI: 10.1021/acsmacrolett.0c00290

A Molecular View of Lipid Nanoparticles: Insights into their Morphology and Structural Plasticity

Sudha Porte, Vadhana V and Durba Sengupta

Small, 2025, 21
DOI: 10.1002/smll.202505404

Self-Assembled Fluorosome–Polydopamine Complex for Efficient Tumor Targeting and Commingled Photodynamic/Photothermal Therapy of Triple-Negative Breast Cancer

Rajalakshmi P.S, Syed Baseeruddin Alvi, Nazia Begum, Bantal Veeresh and Aravind Kumar Rengan

Biomacromolecules, 2021, 22, 3926
DOI: 10.1021/acs.biomac.1c00744

Lipid Bilayer–Coated Core–Shell Silica Nanoparticles with Enhanced Clearance and Biocompatibility for High Sensitivity 19F Magnetic Resonance Imaging

Yue Wu, Masafumi Minoshima and Kazuya Kikuchi

Analysis & Sensing, 2026, 6
DOI: 10.1002/anse.202500178

LIPID-POLYMER HYBRID NANOPARTICLES AND SILICA-BASED HYBRID NANOPARTICLES FOR CANCER TREATMENT

ANJANA A. KAILAS, ANNAMALAI RAMA, BHAUTIK LADANI, INDUJA GOVINDAN, K. A. ABUTWAIBE and ANUP NAHA

Int J App Pharm, 2025, 38
DOI: 10.22159/ijap.2025v17i4.53823

Phase II study of paclitaxel associated with lipid core nanoparticles (LDE) as third-line treatment of patients with epithelial ovarian carcinoma

Silvia R. Graziani, Carolina G. Vital, Aleksandra T. Morikawa, Brigitte M. Van Eyll, Hezio J. Fernandes Junior, Roberto Kalil Filho and Raul C. Maranhão

Med Oncol, 2017, 34
DOI: 10.1007/s12032-017-1009-z

Exploring the Potential of Zein Nanoparticles in Personalised Cancer Therapy, Highlighting Their Various Methodologies, Applications and Challenges

Hanan M. Alharbi, Taha Alqahtani, Nada A. Alqalawi, Shayma A. Alsayegh, Basmah A. Almaghrabi, Subham Sarkar, Daniel Ejim Uti and Bikram Dhara

J Cellular Molecular Medi, 2025, 29
DOI: 10.1111/jcmm.70752

Synthesis and characterization of acetyl curcumin-loaded core/shell liposome nanoparticles via an electrospray process for drug delivery, and theranostic applications

Ankireddy Seshadri Reddy, Buddolla Anantha Lakshmi, Sanghyo Kim and Jongsung Kim

European Journal of Pharmaceutics and Biopharmaceutics, 2019, 142, 518
DOI: 10.1016/j.ejpb.2019.07.024

Biodegradable Micelles Based on Poly(ethylene glycol)-b-polylipopeptide Copolymer: A Robust and Versatile Nanoplatform for Anticancer Drug Delivery

Min Qiu, Jia Ouyang, Huanli Sun, Fenghua Meng, Ru Cheng, Jian Zhang, Liang Cheng, Qing Lan, Chao Deng and Zhiyuan Zhong

ACS Appl. Mater. Interfaces, 2017, 9, 27587
DOI: 10.1021/acsami.7b10533

Threatening cancer with nanoparticle aided combination oncotherapy

Shruti Rawal and Mayur M. Patel

Journal of Controlled Release, 2019, 301, 76
DOI: 10.1016/j.jconrel.2019.03.015

Liposome-Cross-Linked Hybrid Hydrogels for Glutathione-Triggered Delivery of Multiple Cargo Molecules

Yingkai Liang and Kristi L. Kiick

Biomacromolecules, 2016, 17, 601
DOI: 10.1021/acs.biomac.5b01541

Endocytic Selective Toxicity of Rhodamine 6G nanoGUMBOS in Breast Cancer Cells

Nimisha Bhattarai, J. Michael Mathis, Mi Chen, Rocío L. Pérez, Noureen Siraj, Paul K. S. Magut, Karen McDonough, Girija Sahasrabudhe and Isiah M. Warner

Mol. Pharmaceutics, 2018, 15, 3837
DOI: 10.1021/acs.molpharmaceut.8b00339

Revolutionizing Cancer Treatment: The Promising Horizon of Zein Nanosystems

Subham Preetam, Deb Duhita Mondal, Nobendu Mukerjee, Shaikh Sheeran Naser, Tanveer A. Tabish and Nanasaheb Thorat

ACS Biomater. Sci. Eng., 2024, 10, 1946
DOI: 10.1021/acsbiomaterials.3c01540

Core-shell lipid polymer nanoparticles for combined chemo and gene therapy of childhood head and neck cancers

Tiesong Zhang, Jing Ma, Chao Li, Ken Lin, Fan Lou, Hongchao Jiang, Yingqin Gao, Yanli Yang, Cheng Ming and Biao Ruan

Oncology Reports, 2017, 37, 1653
DOI: 10.3892/or.2017.5365

Recent Progress of Nanocarrier-Based Therapy for Solid Malignancies

Qi-Yao Wei, Yan-Ming Xu and Andy T. Y. Lau

Cancers, 2020, 12, 2783
DOI: 10.3390/cancers12102783

Vaccine-like nanomedicine for cancer immunotherapy

Yunfei Yi, Mian Yu, Wen Li, Dunwan Zhu, Lin Mei and Meitong Ou

Journal of Controlled Release, 2023, 355, 760
DOI: 10.1016/j.jconrel.2023.02.015

Emulsion-templated synthesis and in vitro characterizations of niosomes for improved therapeutic potential of hydrophobic anti-cancer drug: tamoxifen

Hamid Saeed Shah, Fazala Khalid, Sajid Bashir, Muhammed Hasham Bin Asad, Kashif-Ur-Rehman Khan, Faisal Usman and Ibrahim Javed

J Nanopart Res, 2019, 21
DOI: 10.1007/s11051-019-4464-y

Nanomedicine Strategies Utilizing Lipid-Based Nanoparticles for Liver Cancer Therapy: Exploring Signaling Pathways and Therapeutic Modalities

Fereshteh Asgharzadeh, Maryam Moradi Binabaj, Sahar Fanoudi, William C. Cho, Yu-jeong Yang, Maryam Azarian, Mehdi Shafiee Ardestani, Nasim Nasiri, Marzieh Ramezani Farani and Yun Suk Huh

Adv Pharm Bull, 2024, 14, 513
DOI: 10.34172/apb.2024.061

Indocyanine green delivery systems for tumour detection and treatments

Elena P. Porcu, Andrea Salis, Elisabetta Gavini, Giovanna Rassu, Marcello Maestri and Paolo Giunchedi

Biotechnology Advances, 2016, 34, 768
DOI: 10.1016/j.biotechadv.2016.04.001

Polymer- and lipid-based gene delivery technology for CAR T cell therapy

Inês S. Pinto, Rosemeyre A. Cordeiro and Henrique Faneca

Journal of Controlled Release, 2023, 353, 196
DOI: 10.1016/j.jconrel.2022.11.038