A single-step multi-level supramolecular system for cancer sonotheranostics

Huirong Lin, Shuang Li, Junqing Wang, Chengchao Chu, Yang Zhang, Xin Pang, Peng Lv, Xiaoyong Wang, Qingliang Zhao, Junjie Chen, Hongmin Chen, Wen Liu, Xiaoyuan Chen and Gang Liu

Nanoscale Horiz., 2019, 4, 190
DOI: 10.1039/C8NH00276B

Nanotechnology-enabled sonodynamic therapy against malignant tumors

Yunxi Huang, Wenhao Ouyang, Zijia Lai, Guanhua Qiu, Zhaoting Bu, Xiaoqi Zhu, Qin wang, Yunfang Yu and Junjie Liu

Nanoscale Adv., 2024, 6, 1974
DOI: 10.1039/D3NA00738C

A theranostic nrGO@MSN-ION nanocarrier developed to enhance the combination effect of sonodynamic therapy and ultrasound hyperthermia for treating tumor

Yu-Wei Chen, Tse-Ying Liu, Po-Hsueh Chang, Po-Hung Hsu, Hao-Li Liu, Hong-Cheu Lin and San-Yuan Chen

Nanoscale, 2016, 8, 12648
DOI: 10.1039/C5NR07782F

Site-specific sonocatalytic tumor suppression by chemically engineered single-crystalline mesoporous titanium dioxide sonosensitizers

Xi Wang, Wenping Wang, Luodan Yu, Yang Tang, Jiaying Cao and Yu Chen

J. Mater. Chem. B, 2017, 5, 4579
DOI: 10.1039/C7TB00938K

Potential sonodynamic anticancer activities of artemether and liposome-encapsulated artemether

Hai-Jun Chen, Xiu-Rong Huang, Xiao-Bin Zhou, Bi-Yuan Zheng and Jian-Dong Huang

Chem. Commun., 2015, 51, 4681
DOI: 10.1039/C5CC00927H

In situconversion of rose bengal microbubbles into nanoparticles for ultrasound imaging guided sonodynamic therapy with enhanced antitumor efficacy

Rui Hou, Xiaolong Liang, Xiaoda Li, Xu Zhang, Xiaotu Ma and Fan Wang

Biomater. Sci., 2020, 8, 2526
DOI: 10.1039/C9BM02046B

Imaging-guided focused ultrasound-induced thermal and sonodynamic effects of nanosonosensitizers for synergistic enhancement of glioblastoma therapy

Qian Wan, Chao Zou, Dehong Hu, Jun Zhou, Mengjie Chen, Changjun Tie, Yangzi Qiao, Fei Yan, Chuanli Cheng, Zonghai Sheng, Bing Zhang, Xin Liu, Dong Liang and Hairong Zheng

Biomater. Sci., 2019, 7, 3007
DOI: 10.1039/C9BM00292H

Dynamics of the phospholipid shell of microbubbles: a fluorescence photoselection and spectral phasor approach

Eli Slenders, Senne Seneca, Sumit Kumar Pramanik, Nick Smisdom, Peter Adriaensens, Martin vandeVen, Anitha Ethirajan and Marcel Ameloot

Chem. Commun., 2018, 54, 4854
DOI: 10.1039/C8CC01012A

Superhydrophobic drug-loaded mesoporous silica nanoparticles capped with β-cyclodextrin for ultrasound image-guided combined antivascular and chemo-sonodynamic therapy

Yi-Ju Ho, Cheng-Han Wu, Qiao-feng Jin, Chih-Yu Lin, Pei-Hua Chiang, Nan Wu, Ching-Hsiang Fan, Chia-Min Yang and Chih-Kuang Yeh

Biomaterials, 2020, 232, 119723
DOI: 10.1016/j.biomaterials.2019.119723

Enhanced sonodynamic therapy by carbon dots-shelled microbubbles with focused ultrasound

Ching-Hsiang Fan, Nan Wu and Chih-Kuang Yeh

Ultrasonics Sonochemistry, 2023, 94, 106342
DOI: 10.1016/j.ultsonch.2023.106342

Energy‐Converting Nanomedicine

Huijing Xiang and Yu Chen

Small, 2019, 15
DOI: 10.1002/smll.201805339

Recent ultrasound advancements for the manipulation of nanobiomaterials and nanoformulations for drug delivery

Sze Shin Low, Chang Nong Lim, Maxine Yew, Wai Siong Chai, Liang Ee Low, Sivakumar Manickam, Beng Ti Tey and Pau Loke Show

Ultrasonics Sonochemistry, 2021, 80, 105805
DOI: 10.1016/j.ultsonch.2021.105805

Polymeric Microbubbles as Delivery Vehicles for Sensitizers in Sonodynamic Therapy

Conor McEwan, Colin Fowley, Nikolitsa Nomikou, Bridgeen McCaughan, Anthony P. McHale and John F. Callan

Langmuir, 2014, 30, 14926
DOI: 10.1021/la503929c

Recent Clinical and Preclinical Advances in External Stimuli-Responsive Therapies for Head and Neck Squamous Cell Carcinoma

Zheng Jiang, Xin Yang, Mailudan Ainiwaer, Fei Chen and Jun Liu

JCM, 2022, 12, 173
DOI: 10.3390/jcm12010173

Comparing the efficacy of photodynamic and sonodynamic therapy in non-melanoma and melanoma skin cancer

Conor McEwan, Heather Nesbitt, Dean Nicholas, Oisin N. Kavanagh, Kevin McKenna, Philip Loan, Iain G. Jack, Anthony P. McHale and John F. Callan

Bioorganic & Medicinal Chemistry, 2016, 24, 3023
DOI: 10.1016/j.bmc.2016.05.015

Targeted chemo-sonodynamic therapy treatment of breast tumours using ultrasound responsive microbubbles loaded with paclitaxel, doxorubicin and Rose Bengal

Keiran Logan, Federica Foglietta, Heather Nesbitt, Yingjie Sheng, Thomas McKaig, Sukanta Kamila, Jinhui Gao, Nikolitsa Nomikou, Bridgeen Callan, Anthony P. McHale and John F. Callan

European Journal of Pharmaceutics and Biopharmaceutics, 2019, 139, 224
DOI: 10.1016/j.ejpb.2019.04.003

Paclitaxel and rose bengal loaded microbubbles for the ultrasound targeted chemo-sonodynamic therapy of pancreatic cancer

Jack Wright, Keiran Logan, Thomas McKaig, Sukanta Kamila, Chloe McClenaghan, Heather Nesbitt, Mark A. Taylor, Mark Love, Eleanor Stride, Jia-Ling Ruan, Anthony P. McHale and John F. Callan

European Journal of Pharmaceutics and Biopharmaceutics, 2026, 218, 114937
DOI: 10.1016/j.ejpb.2025.114937

Combined sonodynamic and antimetabolite therapy for the improved treatment of pancreatic cancer using oxygen loaded microbubbles as a delivery vehicle

Conor McEwan, Sukanta Kamila, Joshua Owen, Heather Nesbitt, Bridgeen Callan, Mark Borden, Nikolitsa Nomikou, Rifat A. Hamoudi, Mark A. Taylor, Eleanor Stride, Anthony P. McHale and John F. Callan

Biomaterials, 2016, 80, 20
DOI: 10.1016/j.biomaterials.2015.11.033

Direct Evidence of Multibubble Sonoluminescence Using Therapeutic Ultrasound and Microbubbles

Estelle Beguin, Shamit Shrivastava, Nikolai V. Dezhkunov, Anthony P. McHale, John F. Callan and Eleanor Stride

ACS Appl. Mater. Interfaces, 2019, 11, 19913
DOI: 10.1021/acsami.9b07084

Treating cancer with sonodynamic therapy: A review

David Costley, Conor Mc Ewan, Colin Fowley, Anthony P. McHale, Jordan Atchison, Nikolitsa Nomikou and John F. Callan

International Journal of Hyperthermia, 2015, 31, 107
DOI: 10.3109/02656736.2014.992484

Simultaneous Intravital Optical and Acoustic Monitoring of Ultrasound-Triggered Nanobubble Generation and Extravasation

Carly Pellow, Meaghan A. O’Reilly, Kullervo Hynynen, Gang Zheng and David E. Goertz

Nano Lett., 2020, 20, 4512
DOI: 10.1021/acs.nanolett.0c01310

Activating Drugs with Sound: Mechanisms Behind Sonodynamic Therapy and the Role of Nanomedicine

Victor Choi, Maneesha A. Rajora and Gang Zheng

Bioconjugate Chem., 2020, 31, 967
DOI: 10.1021/acs.bioconjchem.0c00029

Multifunctional carbon dot/MXene heterojunctions for alleviation of tumor hypoxia and enhanced sonodynamic therapy

Bijiang Geng, Shuang Xu, Longxiang Shen, Fuling Fang, Wenyan Shi and Dengyu Pan

Carbon, 2021, 179, 493
DOI: 10.1016/j.carbon.2021.04.070

A transformable and self-oxygenated smart probe for enhanced tumor sonodynamic therapy

Qingfei Song, Anna Wang, Yuqi Zhang, Jinfeng Zhu, Xiaoyan Wang, Jian Wang and Haibin Shi

Acta Biomaterialia, 2024, 184, 409
DOI: 10.1016/j.actbio.2024.06.019

Micro/Nanoparticle‐Augmented Sonodynamic Therapy (SDT): Breaking the Depth Shallow of Photoactivation

Xiaoqin Qian, Yuanyi Zheng and Yu Chen

Advanced Materials, 2016, 28, 8097
DOI: 10.1002/adma.201602012

Nanodrug with dual-sensitivity to tumor microenvironment for immuno-sonodynamic anti-cancer therapy

Jinsheng Huang, Zecong Xiao, Yongcheng An, Shisong Han, Wei Wu, Yong Wang, Yu Guo and Xintao Shuai

Biomaterials, 2021, 269, 120636
DOI: 10.1016/j.biomaterials.2020.120636

Composite materials for multimodal sonodynamic therapy in biomedical applications

Min Ma, Lili Luo, Yuxuan Ding, Jiayi Zuo, Xiaofen Chai and Libing Liu

Next Materials, 2025, 6, 100442
DOI: 10.1016/j.nxmate.2024.100442

Iridium(III) Complex-Loaded Perfluoropropane Nanobubbles for Enhanced Sonodynamic Therapy

Pinunta Nittayacharn, Eric Abenojar, Massimo La Deda, Loredana Ricciardi, Giuseppe Strangi and Agata A. Exner

Bioconjugate Chem., 2022, 33, 1057
DOI: 10.1021/acs.bioconjchem.1c00082

FeMoO y @MoS x heterostructure coated by cell membrane to promote sono/chemodynamic tumor treatment

Tian Gan, Junjie Nan, Chao Fang, Yongjun Wu, Xiang Li, Junwei Zhao, Yike Fu, Xiujun Cai and Xiang Li

Nano Research, 2025, 18, 94907641
DOI: 10.26599/NR.2025.94907641

Tumor ablation using low-intensity ultrasound and sound excitable drug

Ching-Hsuan Tung, Myung Shin Han, Young Kim, Jianjun Qi and Brian E. O'Neill

Journal of Controlled Release, 2017, 258, 67
DOI: 10.1016/j.jconrel.2017.05.009

Triarylboron‐Doped Acenethiophenes as Organic Sonosensitizers for Highly Efficient Sonodynamic Therapy with Low Phototoxicity

Kanglei Liu, Zhenqi Jiang, Fenggui Zhao, Weizhi Wang, Frieder Jäkle, Nan Wang, Xiaoying Tang, Xiaodong Yin and Pangkuan Chen

Advanced Materials, 2022, 34
DOI: 10.1002/adma.202206594

Recent progress in development of new sonosensitizers for sonodynamic cancer therapy

Haijun Chen, Xiaobin Zhou, Yu Gao, Biyuan Zheng, Fengxiang Tang and Jiandong Huang

Drug Discovery Today, 2014, 19, 502
DOI: 10.1016/j.drudis.2014.01.010

Materials Chemistry of Nanoultrasonic Biomedicine

Hailin Tang, Yuanyi Zheng and Yu Chen

Advanced Materials, 2017, 29
DOI: 10.1002/adma.201604105

Rational molecular design and emerging applications of small-molecule sonosensitizers for sonodynamic therapy

Hongqi Guo, Xiang Cheng, Ying Yin, Ying Chen, Yeshuo Ma, Feng Gao, Fei Chen and Wenbin Zeng

Coordination Chemistry Reviews, 2026, 556, 217693
DOI: 10.1016/j.ccr.2026.217693

Spectroscopic investigation on the sonodynamic damage to protein in the presence of eosine B

Ling-Ling He, Xiao-Xia Wu, Yong-Xia Wang, Xian-Ping Liu, Yan-Ling Song, Yan-Jie Yang, Yan-Ping Gao, Xin Wang, Bin Liu and Xin Wang

Ultrasonics Sonochemistry, 2015, 26, 93
DOI: 10.1016/j.ultsonch.2015.02.002

Emerging Sonodynamic Therapy‐Based Nanomedicines for Cancer Immunotherapy

Yunrong Yang, Jia Huang, Min Liu, Yige Qiu, Qiaohui Chen, Tianjiao Zhao, Zuoxiu Xiao, Yuqi Yang, Yitian Jiang, Qiong Huang and Kelong Ai

Advanced Science, 2023, 10
DOI: 10.1002/advs.202204365

Ultrasonic Activation of Water-Soluble Au25(SR)18 Nanoclusters for Singlet Oxygen Production

Kouhei Kawamura, Daiki Hikosou, Ayaka Inui, Ken Yamamoto, Junichi Yagi, Satoshi Saita and Hideya Kawasaki

J. Phys. Chem. C, 2019, 123, 26644
DOI: 10.1021/acs.jpcc.9b06849

Design and Challenges of Sonodynamic Therapy System for Cancer Theranostics: From Equipment to Sensitizers

Zhuoran Gong and Zhifei Dai

Advanced Science, 2021, 8
DOI: 10.1002/advs.202002178

Ultrasound-Controlled Prodrug Activation: Emerging Strategies in Polymer Mechanochemistry and Sonodynamic Therapy

Xuancheng Fu and Xiaoran Hu

ACS Appl. Bio Mater., 2024, 7, 8040
DOI: 10.1021/acsabm.4c00150

Antibacterial Sonodynamic Therapy: Current Status and Future Perspectives

Jayishnu Roy, Vijayalakshmi Pandey, Iti Gupta and Himanshu Shekhar

ACS Biomater. Sci. Eng., 2021, 7, 5326
DOI: 10.1021/acsbiomaterials.1c00587

Oxygen carrying microbubbles for enhanced sonodynamic therapy of hypoxic tumours

Conor McEwan, Joshua Owen, Eleanor Stride, Colin Fowley, Heather Nesbitt, David Cochrane, Constantin.C. Coussios, M. Borden, Nikolitsa Nomikou, Anthony P. McHale and John F. Callan

Journal of Controlled Release, 2015, 203, 51
DOI: 10.1016/j.jconrel.2015.02.004

Recent progress in sono-photodynamic cancer therapy: From developed new sensitizers to nanotechnology-based efficacy-enhancing strategies

Yilin Zheng, Jinxiang Ye, Ziying Li, Haijun Chen and Yu Gao

Acta Pharmaceutica Sinica B, 2021, 11, 2197
DOI: 10.1016/j.apsb.2020.12.016

Synthesis and biological characterization of novel rose bengal derivatives with improved amphiphilicity for sono-photodynamic therapy

Hai-Jun Chen, Xiao-Bin Zhou, Ai-Lan Wang, Bi-Yuan Zheng, Chih-Kuang Yeh and Jian-Dong Huang

European Journal of Medicinal Chemistry, 2018, 145, 86
DOI: 10.1016/j.ejmech.2017.12.091

Ultrasonic technologies in imaging and drug delivery

Yi-Ju Ho, Chih-Chung Huang, Ching-Hsiang Fan, Hao-Li Liu and Chih-Kuang Yeh

Cell. Mol. Life Sci., 2021, 78, 6119
DOI: 10.1007/s00018-021-03904-9

Ultrasound and Sonochemistry for Radical Polymerization: Sound Synthesis

Thomas G. McKenzie, Fatemeh Karimi, Muthupandian Ashokkumar and Greg G. Qiao

Chemistry A European J, 2019, 25, 5372
DOI: 10.1002/chem.201803771

5-Aminolevulinic acid hydrochloride loaded microbubbles-mediated sonodynamic therapy in pancreatic cancer cells

Wei Yang, Haitao Xu, Qinghao Liu, Chunxun Liu, Jiahe Hu, Ping Liu, Tianyi Fang, Yuxian Bai, Jiuxin Zhu and Rui Xie

Artificial Cells, Nanomedicine, and Biotechnology, 2020, 48, 1178
DOI: 10.1080/21691401.2020.1813743

Porphyrin-Loaded Pluronic Nanobubbles: A New US-Activated Agent for Future Theranostic Applications

Federica Bosca, Peter A. Bielecki, Agata A. Exner and Alessandro Barge

Bioconjugate Chem., 2018, 29, 234
DOI: 10.1021/acs.bioconjchem.7b00732

The Combination of Glycolytic Inhibitor 2-Deoxyglucose and Microbubbles Increases the Effect of 5-Aminolevulinic Acid-Sonodynamic Therapy in Liver Cancer Cells

Rui Xie, Tongying Xu, Jiuxin Zhu, Xiaoli Wei, Wenting Zhu, Longmin Li, Yufeng Wang, Yu Han, Jianhua Zhou and Yuxian Bai

Ultrasound in Medicine & Biology, 2017, 43, 2640
DOI: 10.1016/j.ultrasmedbio.2017.06.031

Emerging Applications of Ultrasound-Contrast Agents in Radiation Therapy

Quezia Lacerda, Mohamed Tantawi, Dennis B. Leeper, Margaret A. Wheatley and John R. Eisenbrey

Ultrasound in Medicine & Biology, 2021, 47, 1465
DOI: 10.1016/j.ultrasmedbio.2021.01.032

A versatile, stimulus-responsive nanoparticle-based platform for use in both sonodynamic and photodynamic cancer therapy

N. Nomikou, K. Curtis, C. McEwan, B.M.G. O’Hagan, B. Callan, J.F. Callan and A.P. McHale

Acta Biomaterialia, 2017, 49, 414
DOI: 10.1016/j.actbio.2016.11.031

Deciphering the hydrodynamics of lipid-coated microbubble sonoluminescence for sonodynamic therapy

Priyankan Datta, Sreejesh Moolayadukkam, Rakesh Prasad Sahu, Ranjan Ganguly, Swarnendu Sen and Ishwar K. Puri

Ultrasonics Sonochemistry, 2024, 111, 107090
DOI: 10.1016/j.ultsonch.2024.107090

WITHDRAWN: Carbon Dots as Promising Carbon Nanomaterials for Diagnostics, Therapeutics, and Regenerative Orofacial Applications

Gamal Abdel Nasser Atia, Sara Z. Mohamed, Noha Taymour, Magdalen M. Soliman, Hamdy Abdel Halim, Hany K. Shalaby, Mohamed M. Ghobashy, Paritosh Barai, Md Azizul Haque and Hasi Rani Barai

Journal of Drug Delivery Science and Technology, 2025, 106808
DOI: 10.1016/j.jddst.2025.106808

Magnetic microbubble mediated chemo-sonodynamic therapy using a combined magnetic-acoustic device

Estelle Beguin, Michael D. Gray, Keiran A. Logan, Heather Nesbitt, Yingjie Sheng, Sukanta Kamila, Lester C. Barnsley, Luca Bau, Anthony P. McHale, John F. Callan and Eleanor Stride

Journal of Controlled Release, 2020, 317, 23
DOI: 10.1016/j.jconrel.2019.11.013

Nanodroplet-enhanced sonodynamic therapy potentiates immune checkpoint blockade for systemic suppression of triple-negative breast cancer

Wenxin Wu, Ming Xu, Bin Qiao, Tongyi Huang, Huanling Guo, Nan Zhang, Luyao Zhou, Manying Li, Yang Tan, Minru Zhang, Xiaoyan Xie, Xintao Shuai and Chunyang Zhang

Acta Biomaterialia, 2023, 158, 547
DOI: 10.1016/j.actbio.2022.12.023

Physical stimulus-triggered dynamic therapy based on two-dimensional sensitizers

Yao Zhu, Albert Yu, Zihan Lv, Yue Wang and Zhongjian Xie

Coordination Chemistry Reviews, 2026, 549, 217315
DOI: 10.1016/j.ccr.2025.217315

State of the art advancements in sonodynamic therapy (SDT): Metal-Organic frameworks for SDT

Zuoxiu Xiao, Qiaohui Chen, Yuqi Yang, Shiqi Tu, Boyu Wang, Yige Qiu, Yitian Jiang, Qiong Huang and Kelong Ai

Chemical Engineering Journal, 2022, 449, 137889
DOI: 10.1016/j.cej.2022.137889

Magnetically responsive microbubbles as delivery vehicles for targeted sonodynamic and antimetabolite therapy of pancreatic cancer

Yingjie Sheng, Estelle Beguin, Heather Nesbitt, Sukanta Kamila, Joshua Owen, Lester C. Barnsley, Bridgeen Callan, Christopher O'Kane, Nikolitsa Nomikou, Rifat Hamoudi, Mark A. Taylor, Mark Love, Paul Kelly, Declan O'Rourke, Eleanor Stride, Anthony P. McHale and John F. Callan

Journal of Controlled Release, 2017, 262, 192
DOI: 10.1016/j.jconrel.2017.07.040

Molecular Sonosensitizer-Loaded Polymer Nanomicelle for Ultrasound-Based Cell Therapy via Singlet Oxygen Generation

Abu Raihan Sarkar and Nikhil R. Jana

ACS Appl. Nano Mater., 2023, 6, 21282
DOI: 10.1021/acsanm.3c04543

Sonodynamic therapy complements PD-L1 immune checkpoint inhibition in a murine model of pancreatic cancer

Heather Nesbitt, Keiran Logan, Keith Thomas, Bridgeen Callan, Jinhui Gao, Thomas McKaig, Mark Taylor, Mark Love, Eleanor Stride, Anthony P. McHale and John F. Callan

Cancer Letters, 2021, 517, 88
DOI: 10.1016/j.canlet.2021.06.003

Sonodynamic Therapy: Advances and Challenges in Clinical Translation

Maxime Lafond, Shin Yoshizawa and Shin‐ichiro Umemura

J of Ultrasound Medicine, 2019, 38, 567
DOI: 10.1002/jum.14733

Advances and perspectives in organic sonosensitizers for sonodynamic therapy

Xuejian Xing, Shaojing Zhao, Ting Xu, Li Huang, Yi Zhang, Minhuan Lan, Changwei Lin, Xiuli Zheng and Pengfei Wang

Coordination Chemistry Reviews, 2021, 445, 214087
DOI: 10.1016/j.ccr.2021.214087

Hypoxia/pH dual-responsive nitroimidazole-modified chitosan/rose bengal derivative nanoparticles for enhanced photodynamic anticancer therapy

Xudong Li, Jun Wang, Ranran Cui, Dekang Xu, Lisheng Zhu, Ziying Li, Haijun Chen, Yu Gao and Lee Jia

Dyes and Pigments, 2020, 179, 108395
DOI: 10.1016/j.dyepig.2020.108395

Multifunctional Ultrasound Microbubbles

Roman A. Barmin, Mirjavad Moosavifar, Andreas Herrmann, Fabian Kiessling, Twan Lammers and Roger M. Pallares

Chem. Rev., 2026, 126, 1949
DOI: 10.1021/acs.chemrev.5c00280

The promising interplay between sonodynamic therapy and nanomedicine

Roberto Canaparo, Federica Foglietta, Nadia Barbero and Loredana Serpe

Advanced Drug Delivery Reviews, 2022, 189, 114495
DOI: 10.1016/j.addr.2022.114495

Ultrasound-Responsive Systems as Components for Smart Materials

Athanasios G. Athanassiadis, Zhichao Ma, Nicolas Moreno-Gomez, Kai Melde, Eunjin Choi, Rahul Goyal and Peer Fischer

Chem. Rev., 2022, 122, 5165
DOI: 10.1021/acs.chemrev.1c00622

Metal–Organic Frameworks (MOF)-Assisted Sonodynamic Therapy in Anticancer Applications

Fangfang Yang, Jun Dong, Zhanfeng Li and Zonghua Wang

ACS Nano, 2023, 17, 4102
DOI: 10.1021/acsnano.2c10251

Advances of therapeutic microbubbles and nanobubbles

Bin Huang, Li Yang, Wenbing Yu, Yan Li, Ling Li and Ning Gu

NSO, 2023, 2, 20220062
DOI: 10.1360/nso/20220062