Issue 12, 2024

Advances in the composition, efficacy, and mimicking of human milk phospholipids

Abstract

Phospholipids are the essential components of human milk, contributing to the enhancement of cognitive development, regulation of immune functions, and mitigation of elevated cholesterol levels. Infant formulas supplemented with phospholipids can change the composition, content, and globule membrane structure of milk lipids, improving their digestive properties and nutritional value. However, mimicking phospholipids in infant formulas is currently limited, and the supplemented standards of phospholipid species and amounts in infant formulas are unknown. Consequently, there is a significant difference between the phospholipids in infant formulas and those in human milk. This article reviews the recent progress in human milk phospholipid research, aiming to describe the composition, content, and positive effects of human milk phospholipids, as well as summarises the dietary sources of phospholipid supplementation and the current state of human milk phospholipid mimicking in infant formulas. This review provides clear directions for research on mimicking human milk phospholipids and evaluating the nutritional functions of phospholipids in infants.

Graphical abstract: Advances in the composition, efficacy, and mimicking of human milk phospholipids

Supplementary files

Article information

Article type
Review Article
Submitted
31 1 2024
Accepted
25 4 2024
First published
24 5 2024

Food Funct., 2024,15, 6254-6273

Advances in the composition, efficacy, and mimicking of human milk phospholipids

Y. Wang, Q. Liu, Y. Liu, W. Qiao, J. Zhao, H. Cao, Y. Liu and L. Chen, Food Funct., 2024, 15, 6254 DOI: 10.1039/D4FO00539B

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