Issue 4, 2024

Engineered plant extracellular vesicles for natural delivery across physiological barriers

Abstract

Extracellular vesicles (EVs) are nanoscale luminal vesicles that participate in the information transfer of proteins, nucleic acids, and lipids between cells, thereby playing a role in the treatment of diseases and the delivery of nutrients. In recent years, plant-derived EVs (PDEVs) containing bioactive compounds have attracted increasing interest due to their better biocompatibility and lower cytotoxicity in healthy tissues. In the biomedical field, PDEVs have been used as cargo carriers to achieve various functions through engineering modification techniques. This review focuses on the biogenesis, isolation, and identification of PDEVs. We discuss the surface functionalization of PDEVs to enhance therapeutic efficacy, thereby improving their efficiency as a next-generation drug delivery vehicle and their feasibility to treat diseases across the physiological barriers, while critically analyzing the current challenges and opportunities.

Graphical abstract: Engineered plant extracellular vesicles for natural delivery across physiological barriers

Article information

Article type
Review Article
Submitted
22 8 2023
Accepted
02 1 2024
First published
12 1 2024

Food Funct., 2024,15, 1737-1757

Engineered plant extracellular vesicles for natural delivery across physiological barriers

Y. Wang, Y. Wu, S. Shen, Y. Liu, Y. Xia, H. Xia, Z. Xie and Y. Xu, Food Funct., 2024, 15, 1737 DOI: 10.1039/D3FO03503D

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