Issue 2, 2024

Efficient post-synthesis incorporation and conjugation of reactive ketones in RNA via 2′-acylation

Abstract

Despite the broad utility of ketones in bioconjugation, few methods exist to introduce them into RNA. Here we develop highly reactive 2′-OH acylating reagents containing strained-ring ketones, and employ them as versatile labeling handles for RNA.

Graphical abstract: Efficient post-synthesis incorporation and conjugation of reactive ketones in RNA via 2′-acylation

Supplementary files

Article information

Article type
Communication
Submitted
18 10 2023
Accepted
21 11 2023
First published
29 11 2023

Chem. Commun., 2024,60, 232-235

Efficient post-synthesis incorporation and conjugation of reactive ketones in RNA via 2′-acylation

R. Shioi, L. Xiao, L. Fang and E. T. Kool, Chem. Commun., 2024, 60, 232 DOI: 10.1039/D3CC05123D

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