Issue 37, 2023

A novel fluoropolymer as a protein delivery vector with robust adjuvant effect for cancer immunotherapy

Abstract

The inefficient treatment using protein-based nanovaccines is largely attributed to their inadequate immunogenicity. Herein, we developed a novel fluoropolymer (PF) via ring-opening polymerization and constructed a fluoropolymer-based nanovaccine for tumor immunotherapy. Due to the existence of fluoroalkyl chains, PF not only played a crucial role in tumor antigen delivery but also exhibited a remarkable adjuvant effect in enhancing the immunogenicity of nanovaccines. The nanovaccines formed by mixing PF with a model antigen ovalbumin (OVA) enhanced the uptake of antigen proteins by dendritic cells (DCs) and promoted the maturation and antigen presentation of DCs. Compared with free OVA, PF/OVA showed better efficacy in both pre-cancer prevention and tumor treatment. Furthermore, the proportion of CD4+ T and CD8+ T cells was significantly increased in lymph nodes and tumors of mice immunized with PF/OVA. Additionally, there was a great enhancement in the levels of key anti-tumor cytokines (TNF-α and IFN-γ) in the serum of the PF/OVA immunized mice. Our research has shown that fluoropolymer PF applied as a protein vector and adjuvant has great potential for the development of nanovaccines with robust immunogenicity.

Graphical abstract: A novel fluoropolymer as a protein delivery vector with robust adjuvant effect for cancer immunotherapy

Supplementary files

Article information

Article type
Paper
Submitted
06 7 2023
Accepted
10 8 2023
First published
06 9 2023

J. Mater. Chem. B, 2023,11, 8933-8942

A novel fluoropolymer as a protein delivery vector with robust adjuvant effect for cancer immunotherapy

Y. Zhan, X. He, Z. Huang, P. Chen, M. Tian, G. Li, X. Yu, X. Song and J. Zhang, J. Mater. Chem. B, 2023, 11, 8933 DOI: 10.1039/D3TB01531A

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