Issue 29, 2023

Chiral amino acid modified boron-dipyrromethene nanoparticles with different photodynamic activities

Abstract

Amino acids are one kind of basic life unit in biological systems. Modification with amino acids may bring interesting properties to the principal molecules. In this work, BDP was modified with L-aspartic acid (Asp) and D-Asp to obtain BDP-LAsp and BDP-DAsp, respectively. The as-synthesized BDPs can self-assemble into uniform nanoparticles (NPs) due to the hydrophilicity of Asp. We found that BDP-LAsp NPs possessed higher photodynamic therapeutic efficacy than BDP-DAsp NPs in fighting against cancer cells and bacteria. This provides a simple design strategy for the modification of photosensitizers in the biomedical field.

Graphical abstract: Chiral amino acid modified boron-dipyrromethene nanoparticles with different photodynamic activities

Supplementary files

Article information

Article type
Paper
Submitted
30 3 2023
Accepted
15 6 2023
First published
16 6 2023

J. Mater. Chem. B, 2023,11, 6853-6858

Chiral amino acid modified boron-dipyrromethene nanoparticles with different photodynamic activities

W. Lei, Q. Wu, H. Wen, Y. Wang, W. Lin, T. Sun and Z. Xie, J. Mater. Chem. B, 2023, 11, 6853 DOI: 10.1039/D3TB00684K

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