Issue 17, 2023

Phosphorene hydrogel conduits as “neurotrophin reservoirs” for promoting regeneration of peripheral nerves

Abstract

Treatment of large gaps in peripheral nerves is a major clinical challenge. Artificial nerve guidance conduits (NGCs) have provided new opportunities for guiding nerve regeneration. In this study, multifunctional black phosphorus (BP) hydrogel NGCs loaded with neuregulin 1 (Nrg1) were fabricated to support peripheral-nerve regeneration: they exhibited good flexibility and nerve regeneration-related cell induction, promoted Schwann-cell proliferation and accelerated neuron-branch elongation. Nrg1 induced the proliferation and migration of Schwann cells, which had beneficial roles in promoting nerve regeneration. In vivo immunofluorescence studies revealed BP hydrogel NGCs loaded with Nrg1 promoted sciatic-nerve regeneration and axon remyelination. Our method has great potential for promoting treatment of peripheral-nerve injuries.

Graphical abstract: Phosphorene hydrogel conduits as “neurotrophin reservoirs” for promoting regeneration of peripheral nerves

Supplementary files

Article information

Article type
Paper
Submitted
19 2 2023
Accepted
22 3 2023
First published
04 4 2023

J. Mater. Chem. B, 2023,11, 3808-3815

Phosphorene hydrogel conduits as “neurotrophin reservoirs” for promoting regeneration of peripheral nerves

T. Hui, C. Wang, L. Yu, C. Zhou and M. Qiu, J. Mater. Chem. B, 2023, 11, 3808 DOI: 10.1039/D3TB00340J

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