Issue 23, 2023

Electrochemical-induced solvent-tuned selective transfer hydrogenation of imidazopyridines with carbazates as hydrogen donors

Abstract

A solvent-tuned electrochemical protocol for the selective transfer hydrogenation of imidazopyridines using carbazates as hydrogen donors has been developed. This electrosynthesis strategy provides a more sustainable and greener way to access partially saturated N-heterocycles by avoiding traditionally employed transition metal catalysts and high-pressure hydrogen. Remarkably, the method is scalable and applicable to late-stage functionalization of complex molecules. A possible mechanism has been proposed on the basis of radical-trapping and cyclic voltammetry experiments.

Graphical abstract: Electrochemical-induced solvent-tuned selective transfer hydrogenation of imidazopyridines with carbazates as hydrogen donors

Supplementary files

Article information

Article type
Paper
Submitted
07 9 2023
Accepted
20 10 2023
First published
23 10 2023

Green Chem., 2023,25, 9705-9710

Electrochemical-induced solvent-tuned selective transfer hydrogenation of imidazopyridines with carbazates as hydrogen donors

Z. Tang, G. Hong, J. Chen, T. Huang, Z. Zhou and L. Wang, Green Chem., 2023, 25, 9705 DOI: 10.1039/D3GC03389A

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