Volume 241, 2023

Solid-state cross-coupling reactions of insoluble aryl halides under polymer-assisted grinding conditions

Abstract

In this study, polymer-assisted grinding (POLAG), a ball-milling technique based on the use of polymer additives, was applied to mechanochemical solid-state Suzuki–Miyaura cross-coupling reactions of insoluble aryl halides. We found that the efficiency of this challenging solid-state cross-coupling was improved by the addition of polytetrafluoroethylene (PTFE) as a POLAG additive under high-temperature ball-milling conditions. Our results suggest that POLAG is a promising approach for controlling the reactivity of insoluble substrates that are barely reactive under conventional solution-based conditions.

Graphical abstract: Solid-state cross-coupling reactions of insoluble aryl halides under polymer-assisted grinding conditions

Associated articles

Supplementary files

Article information

Article type
Paper
Submitted
31 5 2022
Accepted
07 7 2022
First published
07 7 2022

Faraday Discuss., 2023,241, 104-113

Author version available

Solid-state cross-coupling reactions of insoluble aryl halides under polymer-assisted grinding conditions

K. Kubota, T. Seo and H. Ito, Faraday Discuss., 2023, 241, 104 DOI: 10.1039/D2FD00121G

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