Issue 35, 2022

Versatile fully-substituted triazole-functionalized polypeptides with a stable α-helical conformation for gene delivery

Abstract

A library of polypeptides bearing fully-substituted triazoles (FT) was developed via a Cu-catalyzed multicomponent reaction (MCR). Such an MCR allowed the efficient construction of polypeptide platforms. The introduction of FT avoided the undesired hydrogen bonding compared to traditional triazoles and stabilized the α-helix in a broad pH range. Their gene delivery performance in serum also demonstrates their potential in biological applications.

Graphical abstract: Versatile fully-substituted triazole-functionalized polypeptides with a stable α-helical conformation for gene delivery

Supplementary files

Article information

Article type
Communication
Submitted
11 7 2022
Accepted
07 8 2022
First published
12 8 2022

Polym. Chem., 2022,13, 5042-5047

Versatile fully-substituted triazole-functionalized polypeptides with a stable α-helical conformation for gene delivery

X. Xu, S. Liu, H. Gao, M. Li, J. He, Y. Zheng, W. Song and N. Zheng, Polym. Chem., 2022, 13, 5042 DOI: 10.1039/D2PY00894G

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