Issue 3, 2021

A CHA-based DNA stochastic walker that traverses on cell membranes

Abstract

DNA walkers, imitating protein motors, are a class of nucleic acid nanodevice that can move along a precisely defined “track”. With a promising future in materials and biotechnology, DNA walkers have gained extensive attention among researchers. Here, we introduce a catalytic hairpin assembly (CHA)-based DNA walker on cell membranes. We designed hairpin strand (H1) modified cells as tracks. Driven by DNA strand exchange, catalytic strands move on cell membranes and other hairpin strands (H2) in the solution are loaded on cells. Additionally, we also introduce a CHA-based DNA motor and use the motor for cell membrane target sensing.

Graphical abstract: A CHA-based DNA stochastic walker that traverses on cell membranes

Supplementary files

Article information

Article type
Communication
Submitted
29 9 2020
Accepted
20 12 2020
First published
21 12 2020

Nanoscale, 2021,13, 1596-1599

A CHA-based DNA stochastic walker that traverses on cell membranes

Y. Hu and X. Chu, Nanoscale, 2021, 13, 1596 DOI: 10.1039/D0NR06995G

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements