Issue 72, 2021

Ligand switchable site selectivity in C–H alkenylation of thiophenes by turnover-limiting step control

Abstract

The origin of switchable site selectivity during Pd-catalysed C–H alkenylation of heteroarenes has been examined through More O’Ferrall–Jencks, isotope effect, and DFT computational analyses, which indicate substitution of ionic thioether for pyridine dative ligands induces a change from selectivity-determining C–H cleavage to C–C bond formation, respectively.

Graphical abstract: Ligand switchable site selectivity in C–H alkenylation of thiophenes by turnover-limiting step control

Supplementary files

Article information

Article type
Communication
Submitted
28 6 2021
Accepted
10 8 2021
First published
10 8 2021

Chem. Commun., 2021,57, 9076-9079

Ligand switchable site selectivity in C–H alkenylation of thiophenes by turnover-limiting step control

R. Evans, J. Sampson, L. Wang, L. Lückemeier and B. P. Carrow, Chem. Commun., 2021, 57, 9076 DOI: 10.1039/D1CC03456A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements