Issue 35, 2018

Biodegradable polyester unimolecular systems as emerging materials for therapeutic applications

Abstract

Unimolecular micelles, as a class of single-molecular micelles, are structurally stable regardless of their concentrations or alterations of the outer environment such as pH, temperature, ion strength etc. in comparison with conventional polymeric micelles. Polyester unimolecular micelles are extensively applied in bio-medical fields because of their stability, biocompatibility, biodegradability, structural-controllabilty etc. In this review, the most recent developments in polyester unimolecular micelle designs in terms of Boltorn polymer H40 core, cyclodextrin, dendrimer or dendrimer-like polymer, or polyhedral oligomeric silsesquioxane (POSS) based polyester unimolecular micelles are presented. The significance and application in biomedical fields including drug delivery, bio-imaging and theranostics are also classified in this review. Finally, the remaining challenges and future perspectives for further development of unimolecular micelles as therapeutic materials are also discussed.

Graphical abstract: Biodegradable polyester unimolecular systems as emerging materials for therapeutic applications

Article information

Article type
Review Article
Submitted
20 7 2018
Accepted
14 8 2018
First published
15 8 2018

J. Mater. Chem. B, 2018,6, 5488-5498

Biodegradable polyester unimolecular systems as emerging materials for therapeutic applications

X. Liu, X. Fan, L. Jiang, X. J. Loh, Y. Wu and Z. Li, J. Mater. Chem. B, 2018, 6, 5488 DOI: 10.1039/C8TB01883A

To request permission to reproduce material from this article, please go to the Copyright Clearance Center request page.

If you are an author contributing to an RSC publication, you do not need to request permission provided correct acknowledgement is given.

If you are the author of this article, you do not need to request permission to reproduce figures and diagrams provided correct acknowledgement is given. If you want to reproduce the whole article in a third-party publication (excluding your thesis/dissertation for which permission is not required) please go to the Copyright Clearance Center request page.

Read more about how to correctly acknowledge RSC content.

Social activity

Spotlight

Advertisements