Issue 10, 2017

Iridium-catalyzed direct asymmetric reductive amination of aromatic ketones

Abstract

The highly efficient direct catalytic reductive amination of aromatic ketones with diphenylmethanamine is described. Catalyzed by the iridium–monodentate phosphoramidite complex and assisted using additives, this concise and practical route provided chiral amines in high yields and with high enantioselectivity (ee values of up to 99%).

Graphical abstract: Iridium-catalyzed direct asymmetric reductive amination of aromatic ketones

Supplementary files

Article information

Article type
Research Article
Submitted
21 5 2017
Accepted
27 6 2017
First published
28 6 2017

Org. Chem. Front., 2017,4, 1976-1980

Iridium-catalyzed direct asymmetric reductive amination of aromatic ketones

H. Huang, Z. Wu, G. Gao, L. Zhou and M. Chang, Org. Chem. Front., 2017, 4, 1976 DOI: 10.1039/C7QO00400A

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